Today is Monday, Dec. 11, 2017

Department of

Neurosurgery

Current Enrolling Trials

Our office of clinical trials coordinates and conducts investigational studies for the Department of Neurosurgery.

Nurses and physicians, in collaboration with the staff at UC Medical Center, work together to evaluate the safety and efficacy of new devices, drugs, procedures and techniques and to improve the quality of patient care.

Research Match

Additional clinical trials opportunities can be found at ResearchMatch, a registry created through a large network of major academic institutions— including the University of Cincinnati—funded by the National Center for Research Resources, a component of the National Institutes of Health.

ResearchMatch will help match any type of approved study that is looking for people to participate in their study. You may be contacted about different research opportunities ranging from a survey you can do at home to a clinical trial that may involve you traveling to the researcher’s institution.

The UC Neurosurgery Department is currently conducting the following clinical trials:

Traumatic Brain Injury Trials

SD-II: Development and Validation of Spreading Depolarization (SD) Monitoring for TBI Management

Aims:

Extend application of SD monitoring to non-surgical TBI patients (less invasive and non-invasive methods)

Facilitate bedside recognition and use of SD data with automated SD detection software

Objectives:

1: Develop signal-processing methods for automated bedside detection of spreading depolarizations in both ECoG and non-invasive EEG recordings.

2: Determine the incidence of spreading depolarizations in TBI patients requiring intensive care, using EEG, depth electrodes, and subdural strips.

3: Determine whether spreading depolarizations are independently associated with worse neurologic outcomes across the continuum of TBI severity. 

Principal investigator: Jed Hartings, PhD

Co-investigator: Laura Ngwenya, MD, PhD

Sponsor: DoD

Cerebrovascular Trials

CREST-2
Patients with narrowing in their carotid artery without stroke or stroke warning signs (TIAs or mini-strokes) caused by that artery are eligible to participate in a research study called CREST-2. CREST-2 study is comparing intensive medical management alone to intensive medical management used in combination with a procedure to remove plaque buildup from the carotid artery in the neck. For more information, visit: www.crest2trial.org

Principal Investigator: Matthew Flaherty, MD, UC Neurology

Closed Trials or in Follow Up

  • Minimally Invasive Surgery + rt-PA for ICH Evacuation (MISTIE III)
  • Framing Eighteen Coils in Cerebral Aneurysms Trial (FEAT)
  • WEAVE™ Trial: Wingspan® Stent System Post Market Surveillance Study
  • Invasive and Non-invasive monitoring  of SPreading depolarization by ElectroCorticography in Trauma and stroke (INSPECT)
  • INvestigating TREatments for the Prevention of secondary Injury and Disability following TBI (INTREPID)
  • Cancer Genome Atlas Patient Enrollment and Specimen Qualification Criteria Grade II-IV Gliomas
  • Rindopepimut/GM-CSF in Patients with Relapsed EGFRvIII-Positive Glioblastoma
  • Dasatinib or Placebo Combined with Chemoradiotherapy for Glioblastoma
  • First-in-Human Study Evaluating AMG 595 in Subjects with Recurrent Malignant Glioma Expressing Mutant Epidermal Growth Factor Receptor Variant III (EGFRvIII)
  • EDGE-NEWTON: Nimodipine microparticles to Enhance recovery While reducing TOxicity after subarachNoid hemorrhage
  • COAST: Condition of Approval Study for the Treatment of Lumbar Spinal Stenosis with X-STOP® PEEK IPD®
  • DBS Long Term Follow-Up
  • CLEAR III (Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage) Phase III
  • The Injury and Traumatic Stress (INTRuST) Consortium Neuroimagin Acquisition and Archival
  • The Injury and Traumatic Stress (INTRuST) Consortium Biorepository
  • Acoustic Neuromas: Subtotal Resection & Radiosurgery
  • Chiari Malformation Study
  • RAMP: Prospective, Randomized, Multicenter Clinical Study Comparing Axial Lumbar Interbody Fusion (AxiaLIF®) and Transforaminal Lumbar Interbody Fusion (TLIF) Spinal Procedures
  • Brain Tissue Oxygen Monitoring in Traumatic Brain Injury (BOOST II)
  • Spreading Depression in Brain Trauma (COSBID-TBI)
  • CREATE – Cognitive Remediation after Traumatic Exposure Trial
  • Adherus™ Dural Sealant in Cranial Procedures
  • Monitoring of Delayed Ischemia after Subarachnoid Hemorrhage
  • Angio-Seal™ Vascular Closure Device Following Interventional Radiology Procedures
  • PRET: Patients Prone to Recurrence after Endovascular Treatment
  • Target Imaging for Assistance in Treatment of Parkinson's
  • SLV334 in Traumatic Brain Injury
  • Clazosentan in Aneurysmal Subarachnoid Hemorrhage (CONSCIOUS-3)
  • Randomized Evaluation of Carotid Occlusion and Neurocognition (RECON)
  • Carotid Occlusion Surgery Study (COSS)
  • Clazosentan in Aneurysmal Subarachnoid Hemorrhage
  • INFUSE® Bone Graft for Spine Fusion
  • Libra™ Deep Brain Stimulator for Parkinson's Disease
  • Duragen Plus to Minimize Adhesions after Lumbar Discectomy
  • Gliadel Wafers & Permanent I-125 Seeds for Glioblastoma
  • Biomarkers for Subarachnoid Induced Cerebral Vasospasm
  • IVH Removal: Intraventricular rt-PA
  • Carotid Revascularization Endarterectomy vs. Stenting Trial (CREST)
  • Comparison of Dura Sealants for Cranial Surgery
  • New Spinal Sealant for Dura Repair
  • Eon™ Spinal Cord Stimulator for Chronic Back & Leg Pain
  • Prevention of Disability after Spinal Cord Injury (Cethrin)
  • Prevention of Seizures after Brain Injury
  • Near-infrared Spectroscopy to Detect Bleeding in the Brain
  • Brain Stimulation for Arm/Hand Weakness After a Stroke
  • Assessment of Surgery for Cervical Spondylotic Myelopathy
  • Lumbar Stabilization using the AxiaLif system
  • Evaluation of the PathFinder™ System for Pedicle Screw Insertion
  • Evaluation of the CODA Expandable Fusion Cage
  • FlexiCore™ Artificial Disc for the Treatment of Discogenic Pain
  • ChillerStrip™ Hypothermia System for Aneurysm Surgery
  • Safety and Tolerability of DTI-015 in Patients with Recurrent GBM
  • Hemicraniectomy and Durotomy Upon Deterioration from Infarction Related Swelling (HeADDFIRST)
  • Evaluation of ForSite Device to Measure Pupillary Size
  • National Acute Brain Injury Study: Hypothermia II
  • Prevention of Vasospasm & New Infarction after Aneurysmal SAH Following Administration of Clazosentan
  • Evaluation of a Single IV Dose of Dexanabinol in Patients Suffering from Severe TBI
  • Procrit® (Epoetin Alfa) Administered Perioperatively Versus Standard of Care in Blood Conservation in Subjects Undergoing Major Elective Spinal Surgery
  • DuraSeal™ System as an Adjunct to Sutured Dural Repair During Cranial Surgery

Research_Clinical-Trials

More Information

University of Cincinnati
Department of Neurosurgery

Office Location:
Stetson Office Building
260 Stetson Street, Suite 2200
Cincinnati, Ohio 45219
Phone: 513-558-5387