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Neurosurgery

Photo of  Nicholas Marko, MD

Nicholas Marko, MD

Associate Professor Of Neurosurgery; Director, UC Brain Tumor Center

Education/Credentials
  • Doctor of Medicine: George Washington University School of Medicine
  • Bachelor of Science, with Honors: George Washington University

Contact Information

Peer Reviewed Publications

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Ahmad, Maleeha; Weil, Robert J; Marko, Nicholas F 2017. The Genomics of Diffuse Low-Grade Gliomas , , 137-149

Algattas, Hanna; Damania, Dushyant; DeAndrea-Lazarus, Ian; Kimmell, Kristopher T; Marko, Nicholas F; Walter, Kevin A; Vates, G Edward; Jahromi, Babak S 2017. Systematic Review of Safety and Cost-Effectiveness of Venous Thromboembolism Prophylaxis Strategies in Patients Undergoing Craniotomy for Brain Tumor Neurosurgery, , nyx156

Nikdad, Mohammad Sadegh; Farhan, Farshid; Shafizadeh, Milad; Mirmohseni, Atefeh Sadat; Afarideh, Mohsen; Komeleh, Shabnam Asadi; Lashkari, Marzieh; Ganji, Morsaleh; Ghajar, Alireza; Shafiei, Saeed 2017. Glioblastoma Multiforme: an Advanced Analysis of 153 Patients and Review of the Literature Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery, 36 02 , 080-090

Roderick, Oleg; Marko, Nicholas; Sanchez, David; Aryasomajula, Arun 2017. DATA ANALYSIS AND MACHINE LEARNING EFFORT IN HEALTHCARE Internet of Things and Data Analytics Handbook, 11 5 , 295-328

Razzaghi, Talayeh; Roderick, Oleg; Safro, Ilya; Marko, Nicholas 2016. Multilevel weighted support vector machine for classification on healthcare data with missing values PloS one, 11 5 , e0155119

Weston, Cody; Klobusicky, Joe; Weston, Jennifer; Connor, James; Toms, Steven A; Marko, Nicholas F 2016. Aberrations in the Iron Regulatory Gene Signature Are Associated with Decreased Survival in Diffuse Infiltrating Gliomas PloS one, 11 11 , e0166593

Weston, Cody; Klobusicky, Joseph; Weston, Jennifer; Connor, James; Toms, Steven; Marko, Nicholas 2016. Alterations In The Iron Regulatory Gene Signature Are Associated With Decreased Survival In Low Grade Glioma American Journal Of Hematology, 91 3 , E47

Kimmell, Kristopher T; LaSota, Emily; Weil, Robert J; Marko, Nicholas F 2015. Comparative effectiveness analysis of treatment options for single brain metastasis World neurosurgery, 84 5 , 1316-1332

Kimmell, Kristopher T; Weil, Robert J; Marko, Nicholas F 2015. Multi-modal management of acromegaly: a value perspective Pituitary, 18 5 , 658-665

Klobusicky, Joseph J; Aryasomayajula, Arun; Marko, Nicholas 2015. Evolving Patient Compliance Trends: Integrating Clinical, Insurance, and Extrapolated Socioeconomic Data Pituitary, 2015 5 , 766

Weston, Cody; Klobusicky, Joseph; Connor, James; Toms, Steven; Marko, Nicholas 2015. MPTH-20ALTERATIONS IN THE IRON REGULATORY GENE SIGNATURE ARE ASSOCIATED WITH DECREASED SURVIVAL IN LOW GRADE GLIOMA Neuro-Oncology, 17 Suppl 5 , v142

Kimmell, Kristopher; Sanchez, David; Marko, Nicholas 2014. Ql-16cost Effectiveness Analysis Of Glioblastoma Multiforme Therapies Neuro-Oncology, 16 Suppl 5 , v181

Marko, Nicholas F; Weil, Robert J; Schroeder, Jason L; Lang, Frederick F; Suki, Dima; Sawaya, Raymond E 2014. Extent of resection of glioblastoma revisited: personalized survival modeling facilitates more accurate survival prediction and supports a maximum-safe-resection approach to surgery Journal of Clinical Oncology, 32 8 , 774-782

Shahar, T; Rozovski, U; Marko, NF; Tummala, S; Ziu, M; Weinberg, JS; Rao, G; Kumar, VA; Sawaya, R; Prabhu, SS 2014. Human-Clinical Studies Preoperative Imaging to Predict Intraoperative Changes in Tumor-to-Corticospinal Tract Distance: An Analysis of 45 Cases Using High-Field Intraoperative Magnetic Resonance Imaging NEUROSURGERY-BALTIMORE THEN HAGERSTOWN MD-, 75 1 , 23-30

Shahar, Tal; Rozovski, Uri; Marko, Nicholas F; Tummala, Sudhakar; Ziu, Mateo; Weinberg, Jeffrey S; Rao, Ganesh; Kumar, Vinodh A; Sawaya, Raymond; Prabhu, Sujit S 2014. Preoperative imaging to predict intraoperative changes in tumor-to-corticospinal tract distance: an analysis of 45 cases using high-field intraoperative magnetic resonance imaging Neurosurgery, 75 1 , 23-30

Lubelski, Daniel; Abdullah, Kalil G; Weil, Robert J; Marko, Nicholas F 2013. Bevacizumab for radiation necrosis following treatment of high grade glioma: a systematic review of the literature Journal of Neuro-oncology, 115 3 , 317-322

Marko, Nicholas F 2013. Introduction to the Genomics special edition on clinical and translational genomics Nature biotechnology, 31 6 , 492-494

Marko, Nicholas F 2013. The cancer megafund: determinants of success Nature biotechnology, 31 6 , 492-494

Marko, Nicholas F; Hjorth, Johannes; Seicean, Andrea; Tavare, Simon; Weil, Robert; Oh, Michael C 2013. Personalized, Probabilistic Prediction Of Postoperative Complication Risks For Craniotomy Journal of Neurosurgery, 119 2 , A563-A563

Marko, Nicholas F; Hamrahian, Amir H; Hatipoglu, Betul; Weil, Robert J 2013. Relapsing, remitting hypercortisolism in Cushingâ??s disease due to intratumoral hemorrhages in pituitary microadenoma Journal of Clinical Neuroscience, 20 5 , 753-756

Marko, Nicholas F; Weil, Robert J 2013. The molecular biology of WHO Grade II gliomas Neurosurgical focus, 34 2 , E1

Marko, Nicholas F; Weil, Robert J 2013. The Molecular Biology of Diffuse Low-Grade Gliomas Nature Reviews Endocrinology, 8 10 , 99-115

Marko, Nicholas Frank; Weil, Robert John; Schroder, Jason L; Sawaya, Raymond 2013. 148 Extent of Resection of Glioblastoma Revisited: Personalized Survival Modeling Facilitates More Accurate Individualized Survival Prediction and Supports a" Maximum Safe Resection" Approach Surgery Neurosurgery, 60 2 , 169

Rahmathulla, Gazanfar; Marko, Nicholas F; Weil, Robert J 2013. Cerebral radiation necrosis: a review of the pathobiology, diagnosis and management considerations Journal of Clinical Neuroscience, 20 4 , 485-502

Birks, Suzanne; Altinkaya, Melis; Altinkaya, Ali; Pilkington, Geoff; Kurian, Kathreena M; Crosby, Charlene; Hopkins, Kirsten; Williams, Maggie; Donovan, Laura; Birks, Suzanne 2012. Abstracts from the 2012 BNOS Conference Neuro-Oncology, 14 suppl_2 , ii1-ii12

Marko, Nicholas F 2012. Hyperosmolar therapy for intracranial hypertension: time to dispel antiquated myths Neuro-Oncology, 9 4 , 499-499

Marko, Nicholas F 2012. Hypertonic saline, not mannitol, should be considered gold-standard medical therapy for intracranial hypertension Critical Care, 16 1 , 113

Marko, Nicholas F 2012. Performing a Cost Analysis in Spine Outcomes Research: Comparing Ventral and Dorsal Approaches for Cervical Spondylotic Myelopathy COMMENT Critical Care, 16 1 , 113

Marko, Nicholas F; Coughlan, Carolyn; Weil, Robert J 2012. Towards an integrated molecular and clinical strategy to predict early recurrence in surgically resected non-functional pituitary adenomas Journal of Clinical Neuroscience, 19 11 , 1535-1540

Marko, Nicholas F; LaSota, Emily; Hamrahian, Amir H; Weil, Robert J 2012. Comparative effectiveness review of treatment options for pituitary microadenomas in acromegaly Journal of Neurosurgery, 117 3 , 522-538

Marko, Nicholas F; Prayson, Richard A; Weil, Robert J 2012. Sellar mass with vision loss and hypopituitarism Journal of Clinical Neuroscience, 19 9 , 1331

Marko, Nicholas F; Weil, Robert J 2012. A case for reclassifying infiltrating gliomas in adults Journal of Neuro-oncology, 109 3 , 587-591

Marko, Nicholas F; Weil, Robert J 2012. Comparative effectiveness research in neurosurgery Neurosurgical focus, 33 1 , Introduction

Marko, Nicholas F; Weil, Robert J 2012. Non-Gaussian distributions affect identification of expression patterns, functional annotation, and prospective classification in human cancer genomes PloS one, 7 10 , e46935

Marko, Nicholas F; Weil, Robert J 2012. Pituitary gland: new pathways in the pathogenesis of pituitary adenomas Nature Reviews Endocrinology, 8 10 , 572-573

Marko, Nicholas F; Weil, Robert J 2012. The case for a comparative, value-based alternative to the patient-centered outcomes research model for comparative effectiveness research Neurosurgical focus, 33 1 , E8

Marko, Nicholas F; Weil, Robert J 2012. The molecular biology of WHO grade I astrocytomas Neuro-Oncology, 14 12 , 1424-1431

Marko, Nicholas F; Xu, Zhiyuan; Gao, Tianming; Kattan, Michael W; Weil, Robert J 2012. Predicting survival in women with breast cancer and brain metastasis Cancer, 118 15 , 3749-3757

Marko, Nicholas F; Weil, Robert J 2012. Comparative effectiveness research and acromegaly Response Journal of Neuro-oncology, 109 3 , 587-591

Mohammad Mo-Hammadi, Alireza; Recinos, Pablo F; Barnett, Gene H; Weil, Robert J; Vogelbaum, Michael A; Chao, Samuel T; Suh, John H; Marko, Nicholas F; Elson, Paul; Neyman, Gennady 2012. Role of Gamma Knife surgery in patients with 5 or more brain metastases. Clinical article Journal of Neurosurgery, 117 15 , 5

Mohammadi, Alireza Mohammad; Recinos, Pablo F; Barnett, Gene H; Weil, Robert J; Vogelbaum, Michael A; Chao, Samuel T; Suh, John H; Marko, Nicholas F; Elson, Paul; Neyman, Gennady 2012. Role of Gamma Knife surgery in patients with 5 or more brain metastases Journal of Neurosurgery, 117 Special Suppl , 5-12

Piccirillo, Sara Grazia Maria; Spiteri, Inma; Sottoriva, Andrea; Marko, Nicholas; Collins, Peter; Watts, Colin 2012. Tumor-initiating cells in human glioblastoma are heterogeneous populations which reside in distinct environmental niches Neuro-Oncology, 14 02 , 49-49

Piccirillo, SGM; Spiteri, I; Sottoriva, A; Marko, N; Tavare, S; Collins, P; Watts, C 2012. TUMOUR-INITIATING CELLS IN HUMAN GLIOBLASTOMA ARE HETEROGENEOUS POPULATIONS WHICH RESIDE IN DISTINCT ENVIRONMENTAL NICHES Neuro-Oncology, 14 02 , 49-49

Spiteri, Inma; Sottoriva, Andrea; Marko, Nicholas; Tavare, Simon; Collins, Peter; Price, Stephen J; Watts, Colin 2012. TUMOUR-INITIATING CELLS IN HUMAN GLIOBLASTOMA ARE HETEROGENEOUS POPULATIONS WHICH RESIDE IN DISTINCT ENVIRONMENTAL NICHES Neuro-Oncology, 14 4 , 7-7

StaRke, RobeRt Michael 2012. Comparative effectiveness research and acromegaly J Neurosurg, 117 4 , 520-521

Torre-Healy, Andrew; Marko, Nicholas F; Weil, Robert J 2012. Hyperosmolar therapy for intracranial hypertension Neurocritical care, 17 1 , 117-130

Xu, Zhiyuan; Marko, Nicholas F; Angelov, Lilyana; Barnett, Gene H; Chao, Samuel T; Vogelbaum, Michael A; Suh, John H; Weil, Robert J 2012. Impact of preexisting tumor necrosis on the efficacy of stereotactic radiosurgery in the treatment of brain metastases in women with breast cancer Cancer, 118 5 , 1323-1333

Xu, Zhiyuan; Marko, Nicholas F; Chao, Sam T; Angelov, Lilyana; Vogelbaum, Michael A; Suh, John H; Barnett, Gene H; Weil, Robert J 2012. Relationship between HER2 status and prognosis in women with brain metastases from breast cancer International Journal of Radiation Oncology* Biology* Physics, 82 5 , e739-e747

Marko, Nicholas F; Quackenbush, John; Weil, Robert J 2011. Why is there a lack of consensus on molecular subgroups of glioblastoma? Understanding the nature of biological and statistical variability in glioblastoma expression data PloS one, 6 7 , e20826

Marko, Nicholas F; Suh, John H; Chao, Sam T; Barnett, Gene H; Vogelbaum, Michael A; Toms, Steven; Weil, Robert J; Angelov, Lilyana 2011. Gamma knife stereotactic radiosurgery for the management of incidentally-identified brain metastasis from non-small cell lung cancer Journal of Neuro-oncology, 104 3 , 817-824

Marko, Nicholas F; Weil, Robert J 2011. A comparative effectiveness analysis of alternative strategies to assess hypothalamic-pituitary-adrenal axis function after microsurgical resection of pituitary tumors Neurosurgery, 68 6 , 1576-1585

Marko, Nicholas F; Weil, Robert J 2011. An introduction to comparative effectiveness research Neurosurgery, 70 2 , 425-434

Marko, Nicholas F; Weil, Robert J 2011. Management of incidental pituitary tumors Oncology Reviews, 5 4 , 233-239

Marko, Nicholas F; Weil, Robert J 2011. Medical oncology: patients with brain metastases in early-phase trials Nature Reviews Clinical Oncology, 8 7 , 390-391

Siomin, Vitaly; Lin, Jennifer L; Marko, Nicholas F; Barnett, Gene H; Toms, Steven A; Chao, Samuel T; Angelov, Lilyana; Vogelbaum, Michael A; Navaratne, Kapila; Suh, John H 2011. Stereotactic radiosurgical treatment of brain metastases to the choroid plexus International Journal of Radiation Oncology* Biology* Physics, 80 4 , 1134-1142

Marko, Nicholas F; Hamrahian, Amir H; Weil, Robert J 2010. Preoperative ACTH Stimulation Test and Immediate Postoperative Cortisol Levels Accurately Predict Postoperative Hypothalamic-Pituitary-Adrenal Axis Function After Transsphenoidal Surgery Journal of Neurosurgery, 113 2 , A431-A431

Marko, Nicholas F; Weil, Robert J 2010. Comparative Effectiveness Review of Alternate Strategies for Assessing Hypothalamic-Pituitary Axis Function after Microsurgical Resection of Pituitary Adenoma Journal of Neurosurgery, 113 2 , A404-A404

Marko, Nicholas F; Angelov, Lilyana; Toms, Steven A; Suh, John H; Chao, Sam T; Vogelbaum, Michael A; Barnett, Gene H; Weil, Robert J 2010. Stereotactic radiosurgery as single-modality treatment of incidentally identified renal cell carcinoma brain metastases World neurosurgery, 73 3 , 186-193

Marko, Nicholas F; Hamrahian, Amir H; Weil, Robert J 2010. Immediate postoperative cortisol levels accurately predict postoperative hypothalamicâ??pituitaryâ??adrenal axis function after transsphenoidal surgery for pituitary tumors Pituitary, 13 3 , 249-255

Marko, Nicholas F; Prayson, Richard A; Barnett, Gene H; Weil, Robert J 2010. Integrated molecular analysis suggests a three-class model for low-grade gliomas: a proof-of-concept study Genomics, 95 1 , 16-24

Marko, Nicholas F; Quackenbush, John; Weil, Robert J 2010. Om-22. Why Is There A Lack Of Consensus On Molecular Subgroups Of Glioblastoma? Understanding The Nature Of Biological And Statistical Variability In Glioblastoma Expression Data And Their Implications For Molecular Tumor Classification Neuro-Oncology, 12 suppl_4 , iv61â??iv68

Marko, Nicholas F; Weil, Robert J 2010. Mathematical modeling of molecular data in translational medicine: theoretical considerations Science translational medicine, 2 56 , 56rv4-56rv4

Marko, Nicholas F; Weil, Robert J 2010. Radiotherapy: neurocognitive considerations in the treatment of brain metastases Nature Reviews Clinical Oncology, 7 4 , 185-186

Marko, Nicholas F; Weil, Robert J 2010. Surgery: Remission after transsphenoidal surgery for Cushing disease Nature Reviews Endocrinology, 6 6 , 307-309

Marko, Nicholas F; Weil, Robert J 2010. The role of observational investigations in comparative effectiveness research Value in Health, 13 8 , 989-997

Marko, Nicholas F; Prayson, Richard A; Barnett, Gene H; Weil, Robert J 2010. Much attention has been paid on amphibian peptides for their wide-ranging pharmacological properties, clinical potential, and gene-encoded origin. More than 300 antimicrobial peptides (AMPs) from amphibians have been studied. Peptidomics and genomics analysis combined with functional test including microorganism killing, histamine-releasing, and mast cell degranulation was used to investigate antimicrobial Genomics, 95 1 , 66-71

Marko, Nicholas F; Quackenbush, John; Weil, Robert J 2010. Abstract B8: Why is there no consensus on GBM subgroups? Understanding the nature of biological and statistical variability in The Cancer Genome Atlas GBM data and the implications for molecular tumor classification Journal of Clinical Neuroscience, 19 9 , 1331

Marko, Nicholas F; Weil, Robert J 2010. Abstract A23: Patterns of transcriptomic and proteomic expression of SOX4 may suggest a role in the pathophysiology and treatment of gliomas Genomics, 91 5 , 395-406

Marko, Nicholas F; Gonugunta, Vivek A; Hamrahian, Amir H; Usmani, Ali; Mayberg, Marc R; Weil, Robert J 2009. Use of morning serum cortisol level after transsphenoidal resection of pituitary adenoma to predict the need for long-term glucocorticoid supplementation Journal of Neurosurgery, 111 3 , 540-544

Marko, Nicholas F; Suh, John; Barnett, Gene; Toms, Steven; Vogelbaum, Michael A; Chao, Sam; Angelov, Lilyana 2008. Stereotactic radiosurgery as single modality treatment for incidentally-identified non-small cell lung cancer brain metastases Journal of Neuro-oncology, 87 2 , 232-233

Marko, Nicholas F; Toms, Steven A; Barnett, Gene H; Weil, Robert 2008. Genomic expression patterns distinguish long-term from short-term glioblastoma survivors: a preliminary feasibility study Genomics, 91 5 , 395-406

Marko, Nicholas; Prayson, Richard; Barnett, Gene; Weil, Robert 2008. GENE EXPRESSION PROFILING DEMONSTRATES GENOTYPIC VARIABILITY AND MOLECULAR RELATIONSHIPS AMONG LOW-GRADE GLIOMAS Neuro-Oncology, 10 5 , 801-801

Marko, Nicholas F; Weil, Robert J; Toms, Steven A 2007. Nanotechnology in proteomics Expert review of proteomics, 4 5 , 617-626

Marko, Nicholas; Toms, Steven; Barnett, Gene; Weil, Robert 2007. Genomic expression patterns distinguish long-term from short-term glioblastoma survivors Neuro-Oncology, 9 4 , 499-499

Marko, Nicholas F; Frank, Bryan; Quackenbush, John; Lee, Norman H 2005. A robust method for the amplification of RNA in the sense orientation BMC genomics, 6 1 , 27

Polin, Richard S; Marko, Nicholas F; Ammerman, Matthew D; Shaffrey, Mark E; Huang, Wei; Anderson Jr, Frederick A; Caputy, Anthony J; Laws, Edward R 2005. Functional outcomes and survival in patients with high-grade gliomas in dominant and nondominant hemispheres Journal of Neurosurgery, 102 2 , 276-283

MARKO, NICHOLAS F; DIEFFENBACH, PAUL B; YAN, GAI; CERYAK, SUSAN; HOWELL, ROGER W; MCCAFFREY, TIMOTHY A; HU, VALERIE W 2003. Does metabolic radiolabeling stimulate the stress response? Gene expression profiling reveals differential cellular responses to internal beta vs. external gamma radiation The FASEB journal, 17 11 , 1470-1486

Roth, Jonathan N 1966. Abstracts Internet of Things and Data Analytics Handbook, 76 5 , 199-203