Research & Facilities
The productivity of the division has been high, with more than 60 papers published in PubMed-cited journals since January 2003.
There are combined research conferences between the adult and pediatric rheumatology divisions. There has been collaborative research between both groups, and both groups played critical roles in the establishment of a basic and translational immunobiology division and the founding of a new immunobiology graduate program.
The division is the recipient of a funded T32 training grant which allows an additional year of training, including obtaining a Master's in Clinical Training degree for fellows interested in pursuing an academic career.
The division has RO1, R21, PO1 and VA Merit awards of more than $2 million per year.
Fred Finkelman, MD, McDonald Professor of Medicine and professor of pediatrics, has considerable expertise in cytokine biology and the use of mouse models to study immunobiology.
Finkelman's research interests include the regulation of Th2 cytokine responses and Th2 cytokine effects, the roles of TH2 cytokines in host protection against infectious agents, the roles of B cell membrane immunoglobulin in lymphocyte activation and tolerance and the development of a novel method for measuring in vivo cytokine production.
Finkelman's lab has published more than 300 papers and he has been among the 100 most-cited immunologists during the past 20 years. The lab specializes in the use and manipulation of in vivo mouse models to answer questions of biological importance about immunoregulation. His lab has been active in training young faculty members and has recently accepted its first clinical immunology fellow.
William Ridgway, MD, has major areas of investigative interest including autoimmunity, immunogenetics, T cells, autoimmune (Type I) diabetes and autoimmune liver disease (Primary biliary cirrhosis). The goal of his lab is to determine the immunogenetic mechanisms of PBC-like autoimmune liver disease arising in the NOD.c3c4 mouse, and to dissect genetic control of loss of T sell tolerance in nonobese diabetic (NOD) and NOD congenic mice.
Ridgway is a principal investigator on two NIH R01 grants, "The Pathogenesis of Autoimmunity in a Murine Model of Primary Biliary Cirrhosis" and dnTGF Beta RII Mice and PCB." He is also the principal investigator on a Veterans Administration Merit Award, "Immunogenetic Control of Autoimmune biliary disease," as well as an American Diabetes Association basic science grant, "Soluble CD137 therapy of type one diabetes."
Finally, he is the principal investigator on an NIH P30 grant, "A mouse model of Relapsing Polychondritis."
The Division of Immunology is involved in a number of projects that are available for participation by fellows.
These include multiple studies in lupus in collaboration with Hemine Brunner, MD, MSc, at Cincinnati Children's Hospital Medical Center, and neuropsychiatric lupus with Michael Luggen, MD, professor of medicine for the division.
The faculty continue to collaborate with Lesley Arnold, MD, professor in the Department of Psychiatry and Behavioral Neuroscience, on fibromyalgia studies.