Sara C. Kozma, PhD

Alain, Tommy; Lun, XueQing; Martineau, Yvan; Sean, Polen; Pulendran, Bali; Petroulakis, Emmanuel; Zemp, Franz J; Lemay, Chantal G; Roy, Dominic; Bell, John C; Thomas, George; Kozma, Sara C; Forsyth, Peter A; Costa-Mattioli, Mauro; Sonenberg, Nahum 2010. Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production. Proceedings of the National Academy of Sciences of the United States of America, 107 4, 1576-81

Alimonti, Andrea; Nardella, Caterina; Chen, Zhenbang; Clohessy, John G; Carracedo, Arkaitz; Trotman, Lloyd C; Cheng, Ke; Varmeh, Shohreh; Kozma, Sara C; Thomas, George; Rosivatz, Erika; Woscholski, Rudiger; Cognetti, Francesco; Scher, Howard I; Pandolfi, Pier Paolo 2010. A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. The Journal of clinical investigation, 120 3, 681-93

Carnevalli, Larissa S; Masuda, Kouhei; Frigerio, Francesca; Le Bacquer, Olivier; Um, Sung Hee; Gandin, Valentina; Topisirovic, Ivan; Sonenberg, Nahum; Thomas, George; Kozma, Sara C 2010. S6K1 plays a critical role in early adipocyte differentiation. Developmental cell, 18 5, 763-74

Dowling, Ryan J O; Topisirovic, Ivan; Alain, Tommy; Bidinosti, Michael; Fonseca, Bruno D; Petroulakis, Emmanuel; Wang, Xiaoshan; Larsson, Ola; Selvaraj, Anand; Liu, Yi; Kozma, Sara C; Thomas, George; Sonenberg, Nahum 2010. mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. Science (New York, N.Y.), 328 5982, 1172-6

Kalender, Adem; Selvaraj, Anand; Kim, So Young; Gulati, Pawan; Brûlé, Sophie; Viollet, Benoit; Kemp, Bruce E; Bardeesy, Nabeel; Dennis, Patrick; Schlager, John J; Marette, André; Kozma, Sara C; Thomas, George 2010. Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. Cell metabolism, 11 5, 390-401

McFarland-Mancini, Molly M; Funk, Holly M; Paluch, Andrew M; Zhou, Mingfu; Giridhar, Premkumar Vummidi; Mercer, Carol A; Kozma, Sara C; Drew, Angela F 2010. Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor. Journal of immunology (Baltimore, Md. : 1950), 184 12, 7219-28

Montagne, Jacques; Lecerf, Caroline; Parvy, Jean-Philippe; Bennion, Janis M; Radimerski, Thomas; Ruhf, Marie-Laure; Zilbermann, Frederic; Vouilloz, Nicole; Stocker, Hugo; Hafen, Ernst; Kozma, Sara C; Thomas, George 2010. The nuclear receptor DHR3 modulates dS6 kinase-dependent growth in Drosophila. PLoS genetics, 6 , e1000937

Chen, Jian-Kang; Chen, Jianchun; Thomas, George; Kozma, Sara C; Harris, Raymond C 2009. S6 kinase 1 knockout inhibits uninephrectomy- or diabetes-induced renal hypertrophy. American journal of physiology. Renal physiology, 297 3, F585-93

Delgoffe, Greg M; Kole, Thomas P; Zheng, Yan; Zarek, Paul E; Matthews, Krystal L; Xiao, Bo; Worley, Paul F; Kozma, Sara C; Powell, Jonathan D 2009. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity, 30 6, 832-44

González-Rodriguez, Agueda; Alba, Javier; Zimmerman, Valeri; Kozma, Sara C; Valverde, Angela M 2009. S6K1 deficiency protects against apoptosis in hepatocytes. Hepatology (Baltimore, Md.), 50 1, 216-29

Kroczynska, Barbara; Kaur, Surinder; Katsoulidis, Efstratios; Majchrzak-Kita, Beata; Sassano, Antonella; Kozma, Sara C; Fish, Eleanor N; Platanias, Leonidas C 2009. Interferon-dependent engagement of eukaryotic initiation factor 4B via S6 kinase (S6K)- and ribosomal protein S6K-mediated signals. Molecular and cellular biology, 29 10, 2865-75

Nardella, Caterina; Carracedo, Arkaitz; Alimonti, Andrea; Hobbs, Robin M; Clohessy, John G; Chen, Zhenbang; Egia, Ainara; Fornari, Alessandro; Fiorentino, Michelangelo; Loda, Massimo; Kozma, Sara C; Thomas, George; Cordon-Cardo, Carlos; Pandolfi, Pier Paolo 2009. Differential requirement of mTOR in postmitotic tissues and tumorigenesis. Science signaling, 2 55, ra2

Risson, Valérie; Mazelin, Laetitia; Roceri, Mila; Sanchez, Hervé; Moncollin, Vincent; Corneloup, Claudine; Richard-Bulteau, Hélène; Vignaud, Alban; Baas, Dominique; Defour, Aurélia; Freyssenet, Damien; Tanti, Jean-François; Le-Marchand-Brustel, Yannick; Ferrier, Bernard; Conjard-Duplany, Agnès; Romanino, Klaas; Bauché, Stéphanie; Hantaï, Daniel; Mueller, Matthias; Kozma, Sara C; Thomas, George; Rüegg, Markus A; Ferry, Arnaud; Pende, Mario; Bigard, Xavier; Koulmann, Nathalie; Schaeffer, Laurent; Gangloff, Yann-Gaël 2009. Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy. The Journal of cell biology, 187 6, 859-74

Selman, Colin; Tullet, Jennifer M A; Wieser, Daniela; Irvine, Elaine; Lingard, Steven J; Choudhury, Agharul I; Claret, Marc; Al-Qassab, Hind; Carmignac, Danielle; Ramadani, Faruk; Woods, Angela; Robinson, Iain C A; Schuster, Eugene; Batterham, Rachel L; Kozma, Sara C; Thomas, George; Carling, David; Okkenhaug, Klaus; Thornton, Janet M; Partridge, Linda; Gems, David; Withers, Dominic J 2009. Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science (New York, N.Y.), 326 5949, 140-4

Antion, Marcia D; Merhav, Maayan; Hoeffer, Charles A; Reis, Gerald; Kozma, Sara C; Thomas, George; Schuman, Erin M; Rosenblum, Kobi; Klann, Eric 2008. Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity. Learning & memory (Cold Spring Harbor, N.Y.), 15 1, 29-38

Carracedo, Arkaitz; Ma, Li; Teruya-Feldstein, Julie; Rojo, Federico; Salmena, Leonardo; Alimonti, Andrea; Egia, Ainara; Sasaki, Atsuo T; Thomas, George; Kozma, Sara C; Papa, Antonella; Nardella, Caterina; Cantley, Lewis C; Baselga, Jose; Pandolfi, Pier Paolo 2008. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. The Journal of clinical investigation, 118 9, 3065-74

Gulati, Pawan; Gaspers, Lawrence D; Dann, Stephen G; Joaquin, Manel; Nobukuni, Takahiro; Natt, Francois; Kozma, Sara C; Thomas, Andrew P; Thomas, George 2008. Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34. Cell metabolism, 7 5, 456-65

Johansson, Gunnar; Mahller, Yonatan Y; Collins, Margaret H; Kim, Mi-Ok; Nobukuni, Takahiro; Perentesis, John; Cripe, Timothy P; Lane, Heidi A; Kozma, Sara C; Thomas, George; Ratner, Nancy 2008. Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors. Molecular cancer therapeutics, 7 5, 1237-45

Dufour, Jean-François; Huber, Otmar; Kozma, Sara C; Lu, Xin; Toftgård, Rune 2007. Tumour suppressors in liver carcinogenesis. Journal of hepatology, 47 6, 860-7

Nobukuni, Takahiro; Kozma, Sara C; Thomas, George 2007. hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling. Current opinion in cell biology, 19 2, 135-41

Chalhoub, Nader; Kozma, Sara C; Baker, Suzanne J 2006. S6k1 is not required for Pten-deficient neuronal hypertrophy. Brain research, 1100 1, 32-41

Cota, Daniela; Proulx, Karine; Smith, Kathi A Blake; Kozma, Sara C; Thomas, George; Woods, Stephen C; Seeley, Randy J 2006. Hypothalamic mTOR signaling regulates food intake. Science (New York, N.Y.), 312 5775, 927-30

Gangloff, Yann-Gaël; Mueller, Matthias; Dann, Stephen G; Svoboda, Petr; Sticker, Melanie; Spetz, Jean-Francois; Um, Sung Hee; Brown, Eric J; Cereghini, Silvia; Thomas, George; Kozma, Sara C 2004. Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Molecular and cellular biology, 24 21, 9508-16

Pende, Mario; Um, Sung Hee; Mieulet, Virginie; Sticker, Melanie; Goss, Valerie L; Mestan, Jurgen; Mueller, Matthias; Fumagalli, Stefano; Kozma, Sara C; Thomas, George 2004. S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. Molecular and cellular biology, 24 8, 3112-24

Turck, Franziska; Zilbermann, Frederic; Kozma, Sara C; Thomas, George; Nagy, Ferenc 2004. Phytohormones participate in an S6 kinase signal transduction pathway in Arabidopsis. Plant physiology, 134 4, 1527-35

Um, Sung Hee; Frigerio, Francesca; Watanabe, Mitsuhiro; Picard, Frédéric; Joaquin, Manel; Sticker, Melanie; Fumagalli, Stefano; Allegrini, Peter R; Kozma, Sara C; Auwerx, Johan; Thomas, George 2004. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature, 431 7005, 200-5

Garami, Attila; Zwartkruis, Fried J T; Nobukuni, Takahiro; Joaquin, Manel; Roccio, Marta; Stocker, Hugo; Kozma, Sara C; Hafen, Ernst; Bos, Johannes L; Thomas, George 2003. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Molecular cell, 11 6, 1457-66

Kozma, Sara C; Thomas, George 2002. Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K. BioEssays : news and reviews in molecular, cellular and developmental biology, 24 1, 65-71

Patel, Satish; Lochhead, Pamela A; Rena, Graham; Fumagalli, Stefano; Pende, Mario; Kozma, Sara C; Thomas, George; Sutherland, Calum 2002. Insulin regulation of insulin-like growth factor-binding protein-1 gene expression is dependent on the mammalian target of rapamycin, but independent of ribosomal S6 kinase activity. The Journal of biological chemistry, 277 12, 9889-95

Dennis, P B; Jaeschke, A; Saitoh, M; Fowler, B; Kozma, S C; Thomas, G 2001. Mammalian TOR: a homeostatic ATP sensor. Science (New York, N.Y.), 294 5544, 1102-5

Coulonval, K; Vandeput, F; Stein, R C; Kozma, S C; Lamy, F; Dumont, J E 2000. Phosphatidylinositol 3-kinase, protein kinase B and ribosomal S6 kinases in the stimulation of thyroid epithelial cell proliferation by cAMP and growth factors in the presence of insulin. The Biochemical journal, 348 Pt 2 , 351-8

Volarevic, S; Stewart, M J; Ledermann, B; Zilberman, F; Terracciano, L; Montini, E; Grompe, M; Kozma, S C; Thomas, G 2000. Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6. Science (New York, N.Y.), 288 5473, 2045-7

Montagne, J; Stewart, M J; Stocker, H; Hafen, E; Kozma, S C; Thomas, G 1999. Drosophila S6 kinase: a regulator of cell size. Science (New York, N.Y.), 285 5436, 2126-9

Schwab, M S; Kim, S H; Terada, N; Edfjäll, C; Kozma, S C; Thomas, G; Maller, J L 1999. p70(S6K) controls selective mRNA translation during oocyte maturation and early embryogenesis in Xenopus laevis. Molecular and cellular biology, 19 4, 2485-94

Dennis, P B; Pullen, N; Pearson, R B; Kozma, S C; Thomas, G 1998. Phosphorylation sites in the autoinhibitory domain participate in p70(s6k) activation loop phosphorylation. The Journal of biological chemistry, 273 24, 14845-52

Pullen, N; Dennis, P B; Andjelkovic, M; Dufner, A; Kozma, S C; Hemmings, B A; Thomas, G 1998. Phosphorylation and activation of p70s6k by PDK1. Science (New York, N.Y.), 279 5351, 707-10

Shima, H; Pende, M; Chen, Y; Fumagalli, S; Thomas, G; Kozma, S C 1998. Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase. The EMBO journal, 17 22, 6649-59

Turck, F; Kozma, S C; Thomas, G; Nagy, F 1998. A heat-sensitive Arabidopsis thaliana kinase substitutes for human p70s6k function in vivo. Molecular and cellular biology, 18 4, 2038-44

Moser, B A; Dennis, P B; Pullen, N; Pearson, R B; Williamson, N A; Wettenhall, R E; Kozma, S C; Thomas, G 1997. Dual requirement for a newly identified phosphorylation site in p70s6k. Molecular and cellular biology, 17 9, 5648-55

Dennis, P B; Pullen, N; Kozma, S C; Thomas, G 1996. The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases. Molecular and cellular biology, 16 11, 6242-51

Stewart, M J; Berry, C O; Zilberman, F; Thomas, G; Kozma, S C 1996. The Drosophila p70s6k homolog exhibits conserved regulatory elements and rapamycin sensitivity. Proceedings of the National Academy of Sciences of the United States of America, 93 20, 10791-6

Pearson, R B; Dennis, P B; Han, J W; Williamson, N A; Kozma, S C; Wettenhall, R E; Thomas, G 1995. The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain. The EMBO journal, 14 21, 5279-87

Jefferies, H B; Reinhard, C; Kozma, S C; Thomas, G 1994. Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family. Proceedings of the National Academy of Sciences of the United States of America, 91 10, 4441-5

Kozma, S C; Thomas, G 1994. p70s6k/p85s6k: mechanism of activation and role in mitogenesis. Seminars in cancer biology, 5 4, 255-60

Ming, X F; Burgering, B M; Wennström, S; Claesson-Welsh, L; Heldin, C H; Bos, J L; Kozma, S C; Thomas, G 1994. Activation of p70/p85 S6 kinase by a pathway independent of p21ras. Nature, 371 6496, 426-9

Ferrari, S; Pearson, R B; Siegmann, M; Kozma, S C; Thomas, G 1993. The immunosuppressant rapamycin induces inactivation of p70s6k through dephosphorylation of a novel set of sites. The Journal of biological chemistry, 268 22, 16091-4

Kozma, S C; McGlynn, E; Siegmann, M; Reinhard, C; Ferrari, S; Thomas, G 1993. Active baculovirus recombinant p70s6k and p85s6k produced as a function of the infectious response. The Journal of biological chemistry, 268 10, 7134-8

Kozma, S C; Thomas, G 1992. Serine/threonine kinases in the propagation of the early mitogenic response. Reviews of physiology, biochemistry and pharmacology, 119 , 123-55

Lane, H A; Morley, S J; Dorée, M; Kozma, S C; Thomas, G 1992. Identification and early activation of a Xenopus laevis p70s6k following progesterone-induced meiotic maturation. The EMBO journal, 11 5, 1743-9

Reinhard, C; Thomas, G; Kozma, S C 1992. A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation. Proceedings of the National Academy of Sciences of the United States of America, 89 9, 4052-6

Kozma, S C; Ferrari, S; Bassand, P; Siegmann, M; Totty, N; Thomas, G 1990. Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily. Proceedings of the National Academy of Sciences of the United States of America, 87 19, 7365-9

Kozma, S C; Ferrari, S; Thomas, G 1989. Unmasking a growth factor/oncogene-activated S6 phosphorylation cascade. Cellular signalling, 1 3, 219-25

Kozma, S C; Lane, H A; Ferrari, S; Luther, H; Siegmann, M; Thomas, G 1989. A stimulated S6 kinase from rat liver: identity with the mitogen activated S6 kinase of 3T3 cells. The EMBO journal, 8 13, 4125-32

Kozma, S C; Redmond, S M; Fu, X C; Saurer, S M; Groner, B; Hynes, N E 1988. Activation of the receptor kinase domain of the trk oncogene by recombination with two different cellular sequences. The EMBO journal, 7 1, 147-54

Ziemiecki, A; Mueller, R G; Hynes, N E; Krieg, J; Kozma, S C 1988. cDNA sequence of the human ribosomal large subunit protein L7a. Nucleic acids research, 16 21, 10356

Kozma, S C; Bogaard, M E; Buser, K; Saurer, S M; Bos, J L; Groner, B; Hynes, N E 1987. The human c-Kirsten ras gene is activated by a novel mutation in codon 13 in the breast carcinoma cell line MDA-MB231. Nucleic acids research, 15 15, 5963-71

Hynes, N E; Jaggi, R; Kozma, S C; Ball, R; Muellener, D; Wetherall, N T; Davis, B W; Groner, B 1985. New acceptor cell for transfected genomic DNA: oncogene transfer into a mouse mammary epithelial cell line. Molecular and cellular biology, 5 1, 268-72

Pende, M; Kozma, S C; Jaquet, M; Oorschot, V; Burcelin, R; Le Marchand-Brustel, Y; Klumperman, J; Thorens, B; Thomas, G . Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice. Nature, 408 6815, 994-7