Education/CredentialsFellowship: University of Cincinnati (Hematology Oncology )Fellowship: University of Cincinnati Hoxworth Blood Center (Transfusion Medicine and Blood Banking )Residency: Wright State University Hospital (Internal Medicine )Medical Degree: Damascus University School of Medicine Board Certifications & LicensesAmerican Board of Internal Medicine (Hematology) (Certification Date: 2010-11-09) - (Recertification Date: 2020-10-20)American Board of Internal Medicine (Medical Oncology) (Certification Date: 2010-11-10) - (Recertification Date: 2020-09-19) SpecialtiesHematologyInternal MedicineMedical Oncology Contact Information Vontz Center 1310 Office 513-558-2115 Email charifm@ucmail.uc.edu Research InterestsBreast cancer, Hematology Oncology Clinical Interests HematologyHematology and OncologyMedical OncologyBRCA1 GenesBRCA2 GenesBreast CancerFamily History of Breast CancerPositive Genetic Test for Breast Cancer Peer Reviewed Publications Ayrignac, Xavier; Bigaut, Kevin; Pelletier, Jean; de Seze, Jérôme; Demortiere, Sarah; Collongues, Nicolas; Maarouf, Adil; Pinna, Frédéric; Aouinti, Safa; Carra Dallière, Clarisse; Kremer, Laurent; Charif, Mahmoud; Picot, Marie Christine; Labauge, Pierre 2021. First line treatment failure: Predictive factors in a cohort of 863 Relapsing Remitting MS patients. Multiple sclerosis and related disorders, 48 , 102686Bellanger, Guillaume; Biotti, Damien; Adam, Gilles; Darcourt, Jean; Roques, Margaux; Patsoura, Sofia; Savatovsky, Julien; Obadia, Michael; Menjot de Champfleur, Nicolas; Charif, Mahmoud; Labauge, Pierre; Cotton, Francois; Durand Dubief, Françoise; Tourdias, Thomas; Dulau, Cecile; Kremer, Stéphane; De Sèze, Jérôme; Ciron, Jonathan; Varenne, Fanny; Viguier, Alain; Lerebours, Fleur; Larrue, Vincent; Cognard, Christophe; Bonneville, Fabrice 2021. Leptomeningeal enhancement on post-contrast FLAIR images for early diagnosis of Susac syndrome. Multiple sclerosis (Houndmills, Basingstoke, England), , 13524585211012349Kadia, Tapan M; Ravandi, Farhad; Borthakur, Gautam; Konopleva, Marina; DiNardo, Courtney D; Daver, Naval; Pemmaraju, Naveen; Kanagal-Shamanna, Rashmi; Wang, Xuemei; Huang, Xuelin; Pierce, Sherry; Rausch, Caitlin; Burger, Jan; Ferrajoli, Alessandra; Jain, Nitin; Popat, Uday; Estrov, Zeev; Verstovsek, Srdan; Jabbour, Elias; Garcia-Manero, Guillermo; Kantarjian, Hagop 2021. Long-term results of low-intensity chemotherapy with clofarabine or cladribine combined with low-dose cytarabine alternating with decitabine in older patients with newly diagnosed acute myeloid leukemia. American journal of hematology, , Ter Schiphorst, Adrien; Gaillard, Nicolas; Dargazanli, Cyril; Mourand, Isabelle; Corti, Lucas; Charif, Mahmoud; Ayrignac, Xavier; Lippi, Anaïs; Bouly, Stéphane; Thibault, Lalu; Sablot, Denis; Blanchet-Fourcade, Genevieve; Landragin, Nicolas; Costalat, Vincent; Duflos, Claire; Arquizan, Caroline 2021. Symptomatic isolated internal carotid artery occlusion with initial medical management: a monocentric cohort. Journal of neurology, 268 1, 346-355Yang, Yongguang; Leonard, Marissa; Luo, Zhenhua; Yeo, Syn; Bick, Gregory; Hao, Mingang; Cai, Chunmiao; Charif, Mahmoud; Wang, Jiang; Guan, Jun-Lin; Lower, Elyse E; Zhang, Xiaoting 2021. Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer. Cell reports, 34 10, 108822Ayrignac, Xavier; Le Bars, Emmanuelle; Duflos, Claire; Hirtz, Christophe; Maleska Maceski, Aleksandra; Carra-Dallière, Clarisse; Charif, Mahmoud; Pinna, Frédéric; Prin, Pauline; Menjot de Champfleur, Nicolas; Deverdun, Jérémy; Kober, Tobias; Marechal, Bénédicte; Fartaria, Mario Joao; Corredor Jerez, Ricardo; Labauge, Pierre; Lehmann, Sylvain 2020. Serum GFAP in multiple sclerosis: correlation with disease type and MRI markers of disease severity. Scientific reports, 10 1, 10923Dargazanli, Cyril; Mahmoudi, Mehdi; Cappucci, Matteo; Collemiche, François-Louis; Labreuche, Julien; Habza, Othmane; Gascou, Grégory; Lefèvre, Pierre-Henri; Eker, Omer; Mourand, Isabelle; Gaillard, Nicolas; Charif, Mahmoud; Derraz, Imad; Arquizan, Caroline; Costalat, Vincent 2019. Angiographic Patterns and Outcomes Achieved by Proximal Balloon Occlusion in Symptomatic Carotid Artery Stenosis Stenting. Clinical neuroradiology, , Phan, Kim; Charif, Mahmoud 2019. Pembrolizumab for PD-L1-Positive Breast Cancer Refractory to Chemotherapy. American journal of therapeutics, , Lower, Elyse E; Charif, Mahmoud; Bartelt, Meg 2018. Reduced dose pegfilgrastim is associated with less bone pain without increased neutropenia: a retrospective study. Cancer chemotherapy and pharmacology, 82 1, 165-170Khanna, Suchin R; Nguyen, Brave; Charif, Mahmoud 2017. Early-Stage Mucinous Ovarian Adenocarcinoma with Extensive Clotting in a Previously Healthy Young Female Patient: An Uncommon Presentation of a Relatively Uncommon Disease. The American journal of case reports, 18 , 669-673Randhawa J.;Park T.;Malhotra A.;Charif M. 09-01-2017. Two cases of possible remission in metastatic triple-negative breast cancer Journal of Community and Supportive Oncology, 15 5, e176-e178
Clinical Interests HematologyHematology and OncologyMedical OncologyBRCA1 GenesBRCA2 GenesBreast CancerFamily History of Breast CancerPositive Genetic Test for Breast Cancer
Peer Reviewed Publications Ayrignac, Xavier; Bigaut, Kevin; Pelletier, Jean; de Seze, Jérôme; Demortiere, Sarah; Collongues, Nicolas; Maarouf, Adil; Pinna, Frédéric; Aouinti, Safa; Carra Dallière, Clarisse; Kremer, Laurent; Charif, Mahmoud; Picot, Marie Christine; Labauge, Pierre 2021. First line treatment failure: Predictive factors in a cohort of 863 Relapsing Remitting MS patients. Multiple sclerosis and related disorders, 48 , 102686Bellanger, Guillaume; Biotti, Damien; Adam, Gilles; Darcourt, Jean; Roques, Margaux; Patsoura, Sofia; Savatovsky, Julien; Obadia, Michael; Menjot de Champfleur, Nicolas; Charif, Mahmoud; Labauge, Pierre; Cotton, Francois; Durand Dubief, Françoise; Tourdias, Thomas; Dulau, Cecile; Kremer, Stéphane; De Sèze, Jérôme; Ciron, Jonathan; Varenne, Fanny; Viguier, Alain; Lerebours, Fleur; Larrue, Vincent; Cognard, Christophe; Bonneville, Fabrice 2021. Leptomeningeal enhancement on post-contrast FLAIR images for early diagnosis of Susac syndrome. Multiple sclerosis (Houndmills, Basingstoke, England), , 13524585211012349Kadia, Tapan M; Ravandi, Farhad; Borthakur, Gautam; Konopleva, Marina; DiNardo, Courtney D; Daver, Naval; Pemmaraju, Naveen; Kanagal-Shamanna, Rashmi; Wang, Xuemei; Huang, Xuelin; Pierce, Sherry; Rausch, Caitlin; Burger, Jan; Ferrajoli, Alessandra; Jain, Nitin; Popat, Uday; Estrov, Zeev; Verstovsek, Srdan; Jabbour, Elias; Garcia-Manero, Guillermo; Kantarjian, Hagop 2021. Long-term results of low-intensity chemotherapy with clofarabine or cladribine combined with low-dose cytarabine alternating with decitabine in older patients with newly diagnosed acute myeloid leukemia. American journal of hematology, , Ter Schiphorst, Adrien; Gaillard, Nicolas; Dargazanli, Cyril; Mourand, Isabelle; Corti, Lucas; Charif, Mahmoud; Ayrignac, Xavier; Lippi, Anaïs; Bouly, Stéphane; Thibault, Lalu; Sablot, Denis; Blanchet-Fourcade, Genevieve; Landragin, Nicolas; Costalat, Vincent; Duflos, Claire; Arquizan, Caroline 2021. Symptomatic isolated internal carotid artery occlusion with initial medical management: a monocentric cohort. Journal of neurology, 268 1, 346-355Yang, Yongguang; Leonard, Marissa; Luo, Zhenhua; Yeo, Syn; Bick, Gregory; Hao, Mingang; Cai, Chunmiao; Charif, Mahmoud; Wang, Jiang; Guan, Jun-Lin; Lower, Elyse E; Zhang, Xiaoting 2021. Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer. Cell reports, 34 10, 108822Ayrignac, Xavier; Le Bars, Emmanuelle; Duflos, Claire; Hirtz, Christophe; Maleska Maceski, Aleksandra; Carra-Dallière, Clarisse; Charif, Mahmoud; Pinna, Frédéric; Prin, Pauline; Menjot de Champfleur, Nicolas; Deverdun, Jérémy; Kober, Tobias; Marechal, Bénédicte; Fartaria, Mario Joao; Corredor Jerez, Ricardo; Labauge, Pierre; Lehmann, Sylvain 2020. Serum GFAP in multiple sclerosis: correlation with disease type and MRI markers of disease severity. Scientific reports, 10 1, 10923Dargazanli, Cyril; Mahmoudi, Mehdi; Cappucci, Matteo; Collemiche, François-Louis; Labreuche, Julien; Habza, Othmane; Gascou, Grégory; Lefèvre, Pierre-Henri; Eker, Omer; Mourand, Isabelle; Gaillard, Nicolas; Charif, Mahmoud; Derraz, Imad; Arquizan, Caroline; Costalat, Vincent 2019. Angiographic Patterns and Outcomes Achieved by Proximal Balloon Occlusion in Symptomatic Carotid Artery Stenosis Stenting. Clinical neuroradiology, , Phan, Kim; Charif, Mahmoud 2019. Pembrolizumab for PD-L1-Positive Breast Cancer Refractory to Chemotherapy. American journal of therapeutics, , Lower, Elyse E; Charif, Mahmoud; Bartelt, Meg 2018. Reduced dose pegfilgrastim is associated with less bone pain without increased neutropenia: a retrospective study. Cancer chemotherapy and pharmacology, 82 1, 165-170Khanna, Suchin R; Nguyen, Brave; Charif, Mahmoud 2017. Early-Stage Mucinous Ovarian Adenocarcinoma with Extensive Clotting in a Previously Healthy Young Female Patient: An Uncommon Presentation of a Relatively Uncommon Disease. The American journal of case reports, 18 , 669-673Randhawa J.;Park T.;Malhotra A.;Charif M. 09-01-2017. Two cases of possible remission in metastatic triple-negative breast cancer Journal of Community and Supportive Oncology, 15 5, e176-e178
Ayrignac, Xavier; Bigaut, Kevin; Pelletier, Jean; de Seze, Jérôme; Demortiere, Sarah; Collongues, Nicolas; Maarouf, Adil; Pinna, Frédéric; Aouinti, Safa; Carra Dallière, Clarisse; Kremer, Laurent; Charif, Mahmoud; Picot, Marie Christine; Labauge, Pierre 2021. First line treatment failure: Predictive factors in a cohort of 863 Relapsing Remitting MS patients. Multiple sclerosis and related disorders, 48 , 102686Bellanger, Guillaume; Biotti, Damien; Adam, Gilles; Darcourt, Jean; Roques, Margaux; Patsoura, Sofia; Savatovsky, Julien; Obadia, Michael; Menjot de Champfleur, Nicolas; Charif, Mahmoud; Labauge, Pierre; Cotton, Francois; Durand Dubief, Françoise; Tourdias, Thomas; Dulau, Cecile; Kremer, Stéphane; De Sèze, Jérôme; Ciron, Jonathan; Varenne, Fanny; Viguier, Alain; Lerebours, Fleur; Larrue, Vincent; Cognard, Christophe; Bonneville, Fabrice 2021. Leptomeningeal enhancement on post-contrast FLAIR images for early diagnosis of Susac syndrome. Multiple sclerosis (Houndmills, Basingstoke, England), , 13524585211012349Kadia, Tapan M; Ravandi, Farhad; Borthakur, Gautam; Konopleva, Marina; DiNardo, Courtney D; Daver, Naval; Pemmaraju, Naveen; Kanagal-Shamanna, Rashmi; Wang, Xuemei; Huang, Xuelin; Pierce, Sherry; Rausch, Caitlin; Burger, Jan; Ferrajoli, Alessandra; Jain, Nitin; Popat, Uday; Estrov, Zeev; Verstovsek, Srdan; Jabbour, Elias; Garcia-Manero, Guillermo; Kantarjian, Hagop 2021. Long-term results of low-intensity chemotherapy with clofarabine or cladribine combined with low-dose cytarabine alternating with decitabine in older patients with newly diagnosed acute myeloid leukemia. American journal of hematology, , Ter Schiphorst, Adrien; Gaillard, Nicolas; Dargazanli, Cyril; Mourand, Isabelle; Corti, Lucas; Charif, Mahmoud; Ayrignac, Xavier; Lippi, Anaïs; Bouly, Stéphane; Thibault, Lalu; Sablot, Denis; Blanchet-Fourcade, Genevieve; Landragin, Nicolas; Costalat, Vincent; Duflos, Claire; Arquizan, Caroline 2021. Symptomatic isolated internal carotid artery occlusion with initial medical management: a monocentric cohort. Journal of neurology, 268 1, 346-355Yang, Yongguang; Leonard, Marissa; Luo, Zhenhua; Yeo, Syn; Bick, Gregory; Hao, Mingang; Cai, Chunmiao; Charif, Mahmoud; Wang, Jiang; Guan, Jun-Lin; Lower, Elyse E; Zhang, Xiaoting 2021. Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer. Cell reports, 34 10, 108822Ayrignac, Xavier; Le Bars, Emmanuelle; Duflos, Claire; Hirtz, Christophe; Maleska Maceski, Aleksandra; Carra-Dallière, Clarisse; Charif, Mahmoud; Pinna, Frédéric; Prin, Pauline; Menjot de Champfleur, Nicolas; Deverdun, Jérémy; Kober, Tobias; Marechal, Bénédicte; Fartaria, Mario Joao; Corredor Jerez, Ricardo; Labauge, Pierre; Lehmann, Sylvain 2020. Serum GFAP in multiple sclerosis: correlation with disease type and MRI markers of disease severity. Scientific reports, 10 1, 10923Dargazanli, Cyril; Mahmoudi, Mehdi; Cappucci, Matteo; Collemiche, François-Louis; Labreuche, Julien; Habza, Othmane; Gascou, Grégory; Lefèvre, Pierre-Henri; Eker, Omer; Mourand, Isabelle; Gaillard, Nicolas; Charif, Mahmoud; Derraz, Imad; Arquizan, Caroline; Costalat, Vincent 2019. Angiographic Patterns and Outcomes Achieved by Proximal Balloon Occlusion in Symptomatic Carotid Artery Stenosis Stenting. Clinical neuroradiology, , Phan, Kim; Charif, Mahmoud 2019. Pembrolizumab for PD-L1-Positive Breast Cancer Refractory to Chemotherapy. American journal of therapeutics, , Lower, Elyse E; Charif, Mahmoud; Bartelt, Meg 2018. Reduced dose pegfilgrastim is associated with less bone pain without increased neutropenia: a retrospective study. Cancer chemotherapy and pharmacology, 82 1, 165-170Khanna, Suchin R; Nguyen, Brave; Charif, Mahmoud 2017. Early-Stage Mucinous Ovarian Adenocarcinoma with Extensive Clotting in a Previously Healthy Young Female Patient: An Uncommon Presentation of a Relatively Uncommon Disease. The American journal of case reports, 18 , 669-673Randhawa J.;Park T.;Malhotra A.;Charif M. 09-01-2017. Two cases of possible remission in metastatic triple-negative breast cancer Journal of Community and Supportive Oncology, 15 5, e176-e178