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Department of Environmental Health

Division of Environmental Genetics and Molecular Toxicology

Photo of  Divaker Choubey, PhD

Divaker Choubey, PhD

Professor, Department of Environmental Health, UC College of Medicine

Education/Credentials
  • Postdoctoral Training: Yale University, Dept of MB & B
  • Ph. D.: Indian Institute of Science, India
  • MS: G. B. Pantnagar University, India

Contact Information
  • Department of Environmental Health
  • Kettering Hall, Room-246
  • Office 513-558-1014
  • Email Divaker.Choubey@uc.edu

Peer Reviewed Publications

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Choubey D 2019. Type I interferon (IFN)-inducible Absent in Melanoma 2 proteins in neuroinflammation: implications for Alzheimer’s disease Journal of Neuroinflammation, 16 , 236

Choubey D & Panchanathan R 2019. Interferon (IFN)-inducible Absent in Melanoma 2 proteins in the negative regulation of the type I IFN response: Implications for lupus nephritis Cytokine, S1043-4666 19, 30086-9

Choubey D & Panchanathan R 2017. Absent in Melanoma 2 proteins in SLE Clin Immunol, 176 , 42

Choubey, Divaker; Panchanathan, Ravichandran 2017. Absent in Melanoma 2 proteins in SLE. Clinical immunology (Orlando, Fla.), 176 , 42-48

Choubey D 2016. Absent in melanoma 2 proteins in the development of cancer Cellular & Molecular Life Sciences, 73 23, 4383

Choubey D & Panchanathan R 2016. IFI16, an amplifier of DNA-damage response: role in cellular senescence and aging-associated inflammatory diseases (a review) Ageing Research Reviews, 28 , 27

Choubey, Divaker; Panchanathan, Ravichandran 2016. IFI16, an amplifier of DNA-damage response: Role in cellular senescence and aging-associated inflammatory diseases. Ageing research reviews, 28 , 27-36

Hsieh, Heidi; Vignesh, Kavitha Subramanian; Deepe, George S; Choubey, Divaker; Shertzer, Howard G; Genter, Mary Beth 2016. Mechanistic studies of the toxicity of zinc gluconate in the olfactory neuronal cell line Odora. Toxicology in vitro : an international journal published in association with BIBRA, 35 , 24-30

Klionsky DJ et al. 2016. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) Autophagy, 12 1, 1

Panchanathan R, Liu H, Choubey D 2016. Hypoxia primes human normal prostate epithelial cells and cancer cell lines for the NLRP3 and AIM2 inflammasome activation Oncotarget, 73 19, 28183

Panchanathan, Ravichandran; Liu, Hongzhu; Choubey, Divaker 2016. Hypoxia primes human normal prostate epithelial cells and cancer cell lines for the NLRP3 and AIM2 inflammasome activation. Oncotarget, 7 19, 28183-94

Choubey D & Panchanathan R 2015. Comment on "Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune NZB Mice" Journal of immunology (Baltimore, Md. : 1950), 195 10, 4551-2

Khanal T, Kim D, Johnson A, Choubey D, Kim K 2015. Deregulation of NR2E3, an orphan nuclear receptor, by benzo(a)pyrene-induced oxidative stress is associated with histone modification status change of the estrogen receptor gene promoter Toxicol Lett, 237 3, 228-36

Panchanathan R, Liu H, Choubey D 2015. Activation of p53 in Human and Murine Cells by DNA-Damaging Agents Differentially Regulates Aryl Hydrocarbon Receptor Levels Int J Toxicol, 34 3, 242

Panchanathan R, Liu H, Leung YK, Ho SM, Choubey D. 2015. Bisphenol A (BPA) stimulates the interferon signaling and activates the inflammasome activity in myeloid cells Mol Cell Endocrinol, 415 , 45

Panchanathan, Ravichandran; Liu, Hongzhu; Leung, Yuet-Kin; Ho, Shuk-mei; Choubey, Divaker 2015. Bisphenol A (BPA) stimulates the interferon signaling and activates the inflammasome activity in myeloid cells. Molecular and cellular endocrinology, 415 , 45-55

Hughes GC & Choubey D 2014. Modulation of autoimmune rheumatic diseases by oestrogen and progesterone Nat Rev Rheumatol, 10 12, 740-751

Panchanathan R, Liu H, Xin D, Choubey D 2014. Identification of a negative feedback loop between cyclic di-GMP-induced levels of IFI16 and p202 cytosolic DNA sensors and STING Innate immunity, 20 7, 751-9

Panchanathan R & Choubey D 2013. Murine BAFF expression is up-regulated by estrogen and interferons: implications for sex bias in the development of autoimmunity Mol Immunol, 53 1-2, 15-23

Panchanathan R, Liu H, Choubey D 2013. Expression of murine Unc93b1 is up-regulated by interferon and estrogen signaling: implications for sex bias in the development of autoimmunity Int Immunol, 25 9, 521-9

Ponomareva L, Liu H, Duan X, Dickerson E, Shen H, Panchanathan R, Choubey D 2013. AIM2, an IFN-inducible cytosolic DNA sensor, in the development of benign prostate hyperplasia and prostate cancer Mol Cancer Res, 11 10, 1193-202

Yin Q, Sester DP, Tian Y, Hsiao Y-S, Lu A, Cridland JA, Sagulenko V, Thygesen SJ, Choubey D, Hornung V, Walz T, Stacey KJ, Wu H 2013. Molecular mechanism for p202-mediated specific inhibition of AIM2 inflammasome activation Cell reports, 4 2, 327-39

Alimirah F, Peng X, Yuan L, Mehta RR, von Knethen A, Choubey D, Mehta RG 2012. Crosstalk between the peroxisome proliferator-activated receptor γ (PPARγ) and the vitamin D receptor (VDR) in human breast cancer cells: PPARγ binds to VDR and inhibits 1α,25-dihydroxyvitamin D3 mediated transactivation Experimental cell research, 318 19, 2490-7

Choubey D 2012. DNA-responsive inflammasomes and their regulators in autoimmunity Clinical immunology (Orlando, Fla.), 142 3, 223-31

Choubey D 2012. Interferon-inducible Ifi200-family genes as modifiers of lupus susceptibility Immunology letters, 147 1-2, 10-7

Panchanathan, Ravichandran; Liu, Hongzhu; Liu, Hongqi; Fang, Chee-Mun; Erickson, Loren D; Pitha, Paula M; Choubey, Divaker 2012. Distinct regulation of murine lupus susceptibility genes by the IRF5/Blimp-1 axis. Journal of immunology (Baltimore, Md. : 1950), 188 1, 270-8

Veeranki, Sudhakar; Choubey, Divaker 2012. Interferon-inducible p200-family protein IFI16, an innate immune sensor for cytosolic and nuclear double-stranded DNA: regulation of subcellular localization. Molecular immunology, 49 4, 567-71

Choubey, Divaker; Moudgil, Kamal D 2011. Interferons in autoimmune and inflammatory diseases: regulation and roles. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 31 12, 857-65

Choubey, Divaker; Panchanathan, Ravichandran; Duan, Xin; Liu, Hongqi; Liu, Hongzhu 2011. Emerging roles for the interferon-inducible p200-family proteins in sex bias in systemic lupus erythematosus. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 31 12, 893-906

Choubey, Divaker; Panchanathan, Ravichandran; Liu, Hongzhu 2011. Comment on "The inhibiting Fc receptor for IgG, FcgammaRIIB, is a modifier of autoimmune susceptibility". Journal of immunology (Baltimore, Md. : 1950), 187 8, 3909; author reply 3

Duan, Xin; Ponomareva, Larissa; Veeranki, Sudhakar; Choubey, Divaker 2011. IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway. PloS one, 6 5, e19532

Duan, Xin; Ponomareva, Larissa; Veeranki, Sudhakar; Panchanathan, Ravichandran; Dickerson, Eric; Choubey, Divaker 2011. Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts. Molecular cancer research : MCR, 9 5, 589-602

Moudgil, Kamal D; Choubey, Divaker 2011. Cytokines in autoimmunity: role in induction, regulation, and treatment. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 31 10, 695-703

Panchanathan, Ravichandran; Duan, Xin; Arumugam, Muthuvel; Shen, Hui; Liu, Hongzhu; Choubey, Divaker 2011. Cell type and gender-dependent differential regulation of the p202 and Aim2 proteins: implications for the regulation of innate immune responses in SLE. Molecular immunology, 49 1-2, 273-80

Panchanathan, Ravichandran; Shen, Hui; Duan, Xin; Rathinam, Vijay A K; Erickson, Loren D; Fitzgerald, Katherine A; Choubey, Divaker 2011. Aim2 deficiency in mice suppresses the expression of the inhibitory Fcgamma receptor (FcgammaRIIB) through the induction of the IFN-inducible p202, a lupus susceptibility protein. Journal of immunology (Baltimore, Md. : 1950), 186 12, 6762-70

Veeranki, Sudhakar; Duan, Xin; Panchanathan, Ravichandran; Liu, Hongzhu; Choubey, Divaker 2011. IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes. PloS one, 6 10, e27040

Choubey, Divaker; Duan, Xin; Dickerson, Eric; Ponomareva, Larissa; Panchanathan, Ravichandran; Shen, Hui; Srivastava, Ratika 2010. Interferon-inducible p200-family proteins as novel sensors of cytoplasmic DNA: role in inflammation and autoimmunity. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 30 6, 371-80

Choubey, Divaker; Panchanathan, Ravichandran; Shen, Hui; Duan, Xin 2010. Comment on "Development of murine lupus involves the combined genetic contribution of the SLAM and Fc gamma R intervals within the Nba2 autoimmune susceptibility locus". Journal of immunology (Baltimore, Md. : 1950), 184 8, 4051-2; author reply

Panchanathan, Ravichandran; Duan, Xin; Shen, Hui; Rathinam, Vijay A K; Erickson, Loren D; Fitzgerald, Katherine A; Choubey, Divaker 2010. Aim2 deficiency stimulates the expression of IFN-inducible Ifi202, a lupus susceptibility murine gene within the Nba2 autoimmune susceptibility locus. Journal of immunology (Baltimore, Md. : 1950), 185 12, 7385-93

Panchanathan, Ravichandran; Shen, Hui; Zhang, Xiang; Ho, Shuk-Mei; Choubey, Divaker 2010. Mutually positive regulatory feedback loop between interferons and estrogen receptor-alpha in mice: implications for sex bias in autoimmunity. PloS one, 5 5, e10868

Shen, Hui; Panchanathan, Ravichandran; Rajavelu, Priya; Duan, Xin; Gould, Karen A; Choubey, Divaker 2010. Gender-dependent expression of murine Irf5 gene: implications for sex bias in autoimmunity. Journal of molecular cell biology, 2 5, 284-90

Song, Lynda Li; Ponomareva, Larissa; Shen, Hui; Duan, Xin; Alimirah, Fatouma; Choubey, Divaker 2010. Interferon-inducible IFI16, a negative regulator of cell growth, down-regulates expression of human telomerase reverse transcriptase (hTERT) gene. PloS one, 5 1, e8569

Veeranki, Sudhakar; Choubey, Divaker 2010. Systemic lupus erythematosus and increased risk to develop B cell malignancies: role of the p200-family proteins. Immunology letters, 133 1, 1-5

Zimmerman, Mary; Yang, Dafeng; Hu, Xiaolin; Liu, Feiyan; Singh, Nagendra; Browning, Darren; Ganapathy, Vadivel; Chandler, Phillip; Choubey, Divaker; Abrams, Scott I; Liu, Kebin 2010. IFN-? upregulates survivin and Ifi202 expression to induce survival and proliferation of tumor-specific T cells. PloS one, 5 11, e14076

Panchanathan, Ravichandran; Shen, Hui; Bupp, Melanie Gubbels; Gould, Karen A; Choubey, Divaker 2009. Female and male sex hormones differentially regulate expression of Ifi202, an interferon-inducible lupus susceptibility gene within the Nba2 interval. Journal of immunology (Baltimore, Md. : 1950), 183 11, 7031-8

Singh, Rekha; Choubey, Divaker; Chen, Jianming; Leehey, David J 2009. Inhibition of intracellular angiotensin II formation blocks high glucose effect on mesangial matrix. Regulatory peptides, 158 1-3, 103-9

Chen, Jianming; Panchanathan, Ravichandran; Choubey, Divaker 2008. Stimulation of T cells up-regulates expression of Ifi202, an interferon-inducible lupus susceptibility gene, through activation of JNK/c-Jun pathway. Immunology letters, 118 1, 13-20

Choubey, Divaker; Deka, Ranjan; Ho, Shuk-mei 2008. Interferon-inducible IFI16 protein in human cancers and autoimmune diseases. Frontiers in bioscience : a journal and virtual library, 13 , 598-608

Choubey, Divaker; Panchanathan, Ravichandran 2008. Interferon-inducible Ifi200-family genes in systemic lupus erythematosus. Immunology letters, 119 1-2, 32-41

Kim, Marianne K-H; Mason, Jacqueline M; Li, Chi-Ming; Berkofsky-Fessler, Windy; Jiang, Le; Choubey, Divaker; Grundy, Paul E; Tycko, Benjamin; Licht, Jonathan D 2008. A pathologic link between Wilms tumor suppressor gene, WT1, and IFI16. Neoplasia (New York, N.Y.), 10 1, 69-78

Panchanathan, Ravichandran; Xin, Hong; Choubey, Divaker 2008. Disruption of mutually negative regulatory feedback loop between interferon-inducible p202 protein and the E2F family of transcription factors in lupus-prone mice. Journal of immunology (Baltimore, Md. : 1950), 180 9, 5927-34

Song, Lynda Li; Alimirah, Fatouma; Panchanathan, Ravichandran; Xin, Hong; Choubey, Divaker 2008. Expression of an IFN-inducible cellular senescence gene, IFI16, is up-regulated by p53. Molecular cancer research : MCR, 6 11, 1732-41

Alimirah, Fatouma; Chen, Jianming; Davis, Francesca J; Choubey, Divaker 2007. IFI16 in human prostate cancer. Molecular cancer research : MCR, 5 3, 251-9

Alimirah, Fatouma; Panchanathan, Ravichandran; Chen, Jianming; Zhang, Xiang; Ho, Shuk-Mei; Choubey, Divaker 2007. Expression of androgen receptor is negatively regulated by p53. Neoplasia (New York, N.Y.), 9 12, 1152-9

Alimirah, Fatouma; Panchanathan, Ravichandran; Davis, Francesca J; Chen, Jianming; Choubey, Divaker 2007. Restoration of p53 expression in human cancer cell lines upregulates the expression of Notch1: implications for cancer cell fate determination after genotoxic stress. Neoplasia (New York, N.Y.), 9 5, 427-34

Alimirah, Fatouma; Chen, Jianming; Basrawala, Zane; Xin, Hong; Choubey, Divaker 2006. DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: implications for the androgen receptor functions and regulation. FEBS letters, 580 9, 2294-300

Alimirah, Fatouma; Chen, Jianming; Xin, Hong; Choubey, Divaker 2006. Androgen receptor auto-regulates its expression by a negative feedback loop through upregulation of IFI16 protein. FEBS letters, 580 6, 1659-64

Xin, Hong; D'Souza, Sanjay; Jørgensen, Trine N; Vaughan, Andrew T; Lengyel, Peter; Kotzin, Brian L; Choubey, Divaker 2006. Increased expression of Ifi202, an IFN-activatable gene, in B6.Nba2 lupus susceptible mice inhibits p53-mediated apoptosis. Journal of immunology (Baltimore, Md. : 1950), 176 10, 5863-70

Albrecht, Mario; Choubey, Divaker; Lengauer, Thomas 2005. The HIN domain of IFI-200 proteins consists of two OB folds. Biochemical and biophysical research communications, 327 3, 679-87

Pramanik, Rocky; Jørgensen, Trine N; Xin, Hong; Kotzin, Brian L; Choubey, Divaker 2004. Interleukin-6 induces expression of Ifi202, an interferon-inducible candidate gene for lupus susceptibility. The Journal of biological chemistry, 279 16, 16121-7

Xin, Hong; Pereira-Smith, Olivia M; Choubey, Divaker 2004. Role of IFI 16 in cellular senescence of human fibroblasts. Oncogene, 23 37, 6209-17

Amrani, Yassine; Tliba, Omar; Choubey, Divaker; Huang, Chien-Da; Krymskaya, Vera P; Eszterhas, Andrew; Lazaar, Aili L; Panettieri, Reynold A 2003. IFN-gamma inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathway. American journal of physiology. Lung cellular and molecular physiology, 284 6, L1063-71

Chaturvedi, Vijaya; Cesnjaj, Mirjana; Bacon, Patricia; Panella, Jeffery; Choubey, Divaker; Diaz, Manuel O; Nickoloff, Brian J 2003. Role of INK4a/Arf locus-encoded senescent checkpoints activated in normal and psoriatic keratinocytes. The American journal of pathology, 162 1, 161-70

Choubey, Divaker; Pramanik, Rocky; Xin, Hong 2003. Subcellular localization and mechanisms of nucleocytoplasmic distribution of p202, an interferon-inducible candidate for lupus susceptibility. FEBS letters, 553 3, 245-9

Pramanik, Rocky; Qi, Xiaomei; Borowicz, Stanley; Choubey, Divaker; Schultz, Richard M; Han, Jiahuai; Chen, Guan 2003. p38 isoforms have opposite effects on AP-1-dependent transcription through regulation of c-Jun. The determinant roles of the isoforms in the p38 MAPK signal specificity. The Journal of biological chemistry, 278 7, 4831-9

Santiago-Raber, Marie-Laure; Baccala, Roberto; Haraldsson, Katarina M; Choubey, Divaker; Stewart, Timothy A; Kono, Dwight H; Theofilopoulos, Argyrios N 2003. Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice. The Journal of experimental medicine, 197 6, 777-88

Xin, Hong; Curry, Jonathan; Johnstone, Ricky W; Nickoloff, Brian J; Choubey, Divaker 2003. Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence. Oncogene, 22 31, 4831-40

Xin, Hong; Geng, Yanbiao; Pramanik, Rocky; Choubey, Divaker 2003. Induction of p202, a modulator of apoptosis, during oncogenic transformation of NIH 3T3 cells by activated H-Ras (Q61L) contributes to cell survival. Journal of cellular biochemistry, 88 1, 191-204

Xin, Hong; Pramanik, Rocky; Choubey, Divaker 2003. Retinoblastoma (Rb) protein upregulates expression of the Ifi202 gene encoding an interferon-inducible negative regulator of cell growth. Oncogene, 22 31, 4775-85

Choubey, Divaker; Kotzin, Brian L 2002. Interferon-inducible p202 in the susceptibility to systemic lupus. Frontiers in bioscience : a journal and virtual library, 7 , e252-62

Qin, Jian-Zhong; Chaturvedi, Vijaya; Denning, Mitchell F; Bacon, Patricia; Panella, Jeffry; Choubey, Divaker; Nickoloff, Brian J 2002. Regulation of apoptosis by p53 in UV-irradiated human epidermis, psoriatic plaques and senescent keratinocytes. Oncogene, 21 19, 2991-3002