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Department of

Environmental Health

Photo of Pheruza Tarapore

Pheruza Tarapore

  • Ph.D.: University of Cincinnati
  • M.S.: University of Bombay
  • B.S.: University of Bombay

Research/Clinical Interests

RNA therapies for Cancer, Abiraterone resistance markers, Environmental epigenetics and cancer

Contact Information
  • University of Cincinnati
  • Department of Environmental Health
  • 160 Panzeca Way, Kettering Complex
  • Cincinnati, Ohio 45267-0056
  • Office 5135585148
  • Email

Peer Reviewed Publications

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Tarapore, Pheruza; Ying, Jun; Ouyang, Bin; Burke, Barbara; Bracken, Bruce; Ho, Shuk-Mei 2014. Exposure to bisphenol A correlates with early-onset prostate cancer and promotes centrosome amplification and anchorage-independent growth in vitro. PloS one, 9 3, e90332

Lee, Ming-Tsung; Ho, Shuk-Mei; Tarapore, Pheruza; Chung, Irving; Leung, Yuet-Kin 2013. Estrogen receptor beta isoform 5 confers sensitivity of breast cancer cell lines to chemotherapeutic agent-induced apoptosis through interaction with Bcl2L12. Neoplasia (New York, N.Y.), 15 11, 1262-71

Lee, Ming-Tsung; Leung, Yuet-Kin; Chung, Irving; Tarapore, Pheruza; Ho, Shuk-Mei 2013. Estrogen receptor beta (ERbeta1) transactivation is differentially modulated by the transcriptional coregulator Tip60 in a cis-acting element-dependent manner. The Journal of biological chemistry, 288 35, 25038-52

Smithrud, David B; Wang, Xiaoyang; Tarapore, Pheruza; Ho, Shuk-Mei 2013. Crown Ether Host-Rotaxanes as Cytotoxic Agents. ACS medicinal chemistry letters, 4 1, 27-31

Ho, Shuk-Mei; Johnson, Abby; Tarapore, Pheruza; Janakiram, Vinothini; Zhang, Xiang; Leung, Yuet-Kin 2012. Environmental epigenetics and its implication on disease risk and health outcomes. ILAR journal / National Research Council, Institute of Laboratory Animal Resources, 53 3-4, 289-305

Isaac, Jared; Tarapore, Pheruza; Zhang, Xiang; Lam, Ying-Wai; Ho, Shuk-Mei 2012. Site-specific S-nitrosylation of integrin ?6 increases the extent of prostate cancer cell migration by enhancing integrin alpha1 association and weakening adherence to laminin-1. Biochemistry, 51 48, 9689-97

Leung, Yuet-Kin; Lee, Ming-Tsung; Lam, Hung-Ming; Tarapore, Pheruza; Ho, Shuk-Mei 2012. Estrogen receptor-beta and breast cancer: translating biology into clinical practice. Steroids, 77 7, 727-37

Tarapore, Pheruza; Hanashiro, Kazuhiko; Fukasawa, Kenji 2012. Analysis of centrosome localization of BRCA1 and its activity in suppressing centrosomal aster formation. Cell cycle (Georgetown, Tex.), 11 15, 2931-46

Tarapore, Pheruza; Shu, Yi; Guo, Peixuan; Ho, Shuk-Mei 2011. Application of phi29 motor pRNA for targeted therapeutic delivery of siRNA silencing metallothionein-IIA and survivin in ovarian cancers. Molecular therapy : the journal of the American Society of Gene Therapy, 19 2, 386-94

Shinmura, K; Bennett, R A; Tarapore, P; Fukasawa, K 2007. Direct evidence for the role of centrosomally localized p53 in the regulation of centrosome duplication. Oncogene, 26 20, 2939-44

Tarapore, Pheruza; Shinmura, Kazuya; Suzuki, Hitoshi; Tokuyama, Yukari; Kim, Song-Hee; Mayeda, Akila; Fukasawa, Kenji 2006. Thr199 phosphorylation targets nucleophosmin to nuclear speckles and represses pre-mRNA processing. FEBS letters, 580 2, 399-409

Mayhew, Christopher N; Bosco, Emily E; Fox, Sejal R; Okaya, Tomohisa; Tarapore, Pheruza; Schwemberger, Sandy J; Babcock, George F; Lentsch, Alex B; Fukasawa, Kenji; Knudsen, Erik S 2005. Liver-specific pRB loss results in ectopic cell cycle entry and aberrant ploidy. Cancer research, 65 11, 4568-77

Shinmura, Kazuya; Tarapore, Pheruza; Tokuyama, Yukari; George, Kyle R; Fukasawa, Kenji 2005. Characterization of centrosomal association of nucleophosmin/B23 linked to Crm1 activity. FEBS letters, 579 29, 6621-34

Tarapore, Pheruza; Fukasawa, Kenji 2002. Loss of p53 and centrosome hyperamplification. Oncogene, 21 40, 6234-40

Tarapore, Pheruza; Okuda, Masaru; Fukasawa, Kenji 2002. A mammalian in vitro centriole duplication system: evidence for involvement of CDK2/cyclin E and nucleophosmin/B23 in centrosome duplication. Cell cycle (Georgetown, Tex.), 1 1, 75-81

Tarapore, P; Horn, H F; Tokuyama, Y; Fukasawa, K 2001. Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway. Oncogene, 20 25, 3173-84

Tarapore, P; Tokuyama, Y; Horn, H F; Fukasawa, K 2001. Difference in the centrosome duplication regulatory activity among p53 'hot spot' mutants: potential role of Ser 315 phosphorylation-dependent centrosome binding of p53. Oncogene, 20 47, 6851-63

Tokuyama, Y; Horn, H F; Kawamura, K; Tarapore, P; Fukasawa, K 2001. Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication. The Journal of biological chemistry, 276 24, 21529-37

Mussman, J G; Horn, H F; Carroll, P E; Okuda, M; Tarapore, P; Donehower, L A; Fukasawa, K 2000. Synergistic induction of centrosome hyperamplification by loss of p53 and cyclin E overexpression. Oncogene, 19 13, 1635-46

Okuda, M; Horn, H F; Tarapore, P; Tokuyama, Y; Smulian, A G; Chan, P K; Knudsen, E S; Hofmann, I A; Snyder, J D; Bove, K E; Fukasawa, K 2000. Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. Cell, 103 1, 127-40

Tarapore, P; Fukasawa, K 2000. p53 mutation and mitotic infidelity. Cancer investigation, 18 2, 148-55

Carroll, P E; Okuda, M; Horn, H F; Biddinger, P; Stambrook, P J; Gleich, L L; Li, Y Q; Tarapore, P; Fukasawa, K 1999. Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression. Oncogene, 18 11, 1935-44

Tarapore, P; Richmond, C; Zheng, G; Cohen, S B; Kelder, B; Kopchick, J; Kruse, U; Sippel, A E; Colmenares, C; Stavnezer, E 1997. DNA binding and transcriptional activation by the Ski oncoprotein mediated by interaction with NFI. Nucleic acids research, 25 19, 3895-903