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Department of

Environmental Health

Pheruza Tarapore

  • Ph.D.: University of Cincinnati
  • M.S.: University of Bombay
  • B.S.: University of Bombay

Research/Clinical Interests

RNA therapies for Cancer, Abiraterone resistance markers, Environmental epigenetics and cancer

Contact Information
  • University of Cincinnati
  • Department of Environmental Health
  • 160 Panzeca Way, Kettering Complex
  • Cincinnati, Ohio 45267-0056
  • Office 5135585148
  • Email

Peer Reviewed Publications

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Tarapore, P., Ying, J., Ouyang, B., Burke, B., Bracken, B., & Ho, S. 2014. Exposure to bisphenol A correlates with early-onset prostate cancer and promotes centrosome amplification and anchorage-independent growth in vitro. PloS One, 9 3, e90332

Lee, M., Ho, S., Tarapore, P., Chung, I., & Leung, Y. 2013. Estrogen receptor beta isoform 5 confers sensitivity of breast cancer cell lines to chemotherapeutic agent-induced apoptosis through interaction with Bcl2L12. Neoplasia (New York, N.Y.), 15 11, 1262-71

Lee, M., Leung, Y., Chung, I., Tarapore, P., & Ho, S. 2013. Estrogen receptor beta (ERbeta1) transactivation is differentially modulated by the transcriptional coregulator Tip60 in a cis-acting element-dependent manner. The Journal of Biological Chemistry, 288 35, 25038-52

Smithrud, D. B., Wang, X., Tarapore, P., & Ho, S. 2013. Crown Ether Host-Rotaxanes as Cytotoxic Agents. ACS Medicinal Chemistry Letters, 4 1, 27-31

Ho, S., Johnson, A., Tarapore, P., Janakiram, V., Zhang, X., & Leung, Y. 2012. Environmental epigenetics and its implication on disease risk and health outcomes. ILAR Journal / National Research Council, Institute of Laboratory Animal Resources, 53 3-4, 289-305

Isaac, J., Tarapore, P., Zhang, X., Lam, Y., & Ho, S. 2012. Site-specific S-nitrosylation of integrin ?6 increases the extent of prostate cancer cell migration by enhancing integrin alpha1 association and weakening adherence to laminin-1. Biochemistry, 51 48, 9689-97

Leung, Y., Lee, M., Lam, H., Tarapore, P., & Ho, S. 2012. Estrogen receptor-beta and breast cancer: translating biology into clinical practice. Steroids, 77 7, 727-37

Tarapore, P., Hanashiro, K., & Fukasawa, K. 2012. Analysis of centrosome localization of BRCA1 and its activity in suppressing centrosomal aster formation. Cell Cycle (Georgetown, Tex.), 11 15, 2931-46

Tarapore, P., Shu, Y., Guo, P., & Ho, S. 2011. Application of phi29 motor pRNA for targeted therapeutic delivery of siRNA silencing metallothionein-IIA and survivin in ovarian cancers. Molecular Therapy : the Journal of the American Society of Gene Therapy, 19 2, 386-94

Shinmura, K., Bennett, R. A., Tarapore, P., & Fukasawa, K. 2007. Direct evidence for the role of centrosomally localized p53 in the regulation of centrosome duplication. Oncogene, 26 20, 2939-44

Tarapore, P., Shinmura, K., Suzuki, H., Tokuyama, Y., Kim, S., Mayeda, A., & Fukasawa, K. 2006. Thr199 phosphorylation targets nucleophosmin to nuclear speckles and represses pre-mRNA processing. FEBS Letters, 580 2, 399-409

Mayhew, C. N., Bosco, E. E., Fox, S. R., Okaya, T., Tarapore, P., Schwemberger, S. J., Babcock, G. F., Lentsch, A. B., Fukasawa, K., & Knudsen, E. S. 2005. Liver-specific pRB loss results in ectopic cell cycle entry and aberrant ploidy. Cancer Research, 65 11, 4568-77

Shinmura, K., Tarapore, P., Tokuyama, Y., George, K. R., & Fukasawa, K. 2005. Characterization of centrosomal association of nucleophosmin/B23 linked to Crm1 activity. FEBS Letters, 579 29, 6621-34

Tarapore, P., Okuda, M., & Fukasawa, K. 2002. A mammalian in vitro centriole duplication system: evidence for involvement of CDK2/cyclin E and nucleophosmin/B23 in centrosome duplication. Cell Cycle (Georgetown, Tex.), 1 1, 75-81

Tarapore, P., & Fukasawa, K. 2002. Loss of p53 and centrosome hyperamplification. Oncogene, 21 40, 6234-40

Tarapore, P., Horn, H. F., Tokuyama, Y., & Fukasawa, K. 2001. Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway. Oncogene, 20 25, 3173-84

Tarapore, P., Tokuyama, Y., Horn, H. F., & Fukasawa, K. 2001. Difference in the centrosome duplication regulatory activity among p53 'hot spot' mutants: potential role of Ser 315 phosphorylation-dependent centrosome binding of p53. Oncogene, 20 47, 6851-63

Tokuyama, Y., Horn, H. F., Kawamura, K., Tarapore, P., & Fukasawa, K. 2001. Specific phosphorylation of nucleophosmin on Thr(199) by cyclin-dependent kinase 2-cyclin E and its role in centrosome duplication. The Journal of Biological Chemistry, 276 24, 21529-37

Mussman, J. G., Horn, H. F., Carroll, P. E., Okuda, M., Tarapore, P., Donehower, L. A., & Fukasawa, K. 2000. Synergistic induction of centrosome hyperamplification by loss of p53 and cyclin E overexpression. Oncogene, 19 13, 1635-46

Okuda, M., Horn, H. F., Tarapore, P., Tokuyama, Y., Smulian, A. G., Chan, P. K., Knudsen, E. S., Hofmann, I. A., Snyder, J. D., Bove, K. E., & Fukasawa, K. 2000. Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication. Cell, 103 1, 127-40

Tarapore, P., & Fukasawa, K. 2000. p53 mutation and mitotic infidelity. Cancer Investigation, 18 2, 148-55

Carroll, P. E., Okuda, M., Horn, H. F., Biddinger, P., Stambrook, P. J., Gleich, L. L., Li, Y. Q., Tarapore, P., & Fukasawa, K. 1999. Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression. Oncogene, 18 11, 1935-44

Tarapore, P., Richmond, C., Zheng, G., Cohen, S. B., Kelder, B., Kopchick, J., Kruse, U., Sippel, A. E., Colmenares, C., & Stavnezer, E. 1997. DNA binding and transcriptional activation by the Ski oncoprotein mediated by interaction with NFI. Nucleic Acids Research, 25 19, 3895-903