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Department of

Environmental Health

Alexey Porollo, PhD

Assistant Professor

Education/Credentials
  • Master's Degree: Mari State University
  • Doctoral Degree: Tver State University
  • Postdoctorate: Children’s Hospital Medical Center

Research/Clinical Interests

Biomedical Informatics

Contact Information
  • Cincinnati Children's Hospital Medical Center
  • 3333 Burnett Avenue
  • Cincinnati, Ohio 45267
  • Office 513-803-5489
  • Email alexey.porollo@cchmc.org

Peer Reviewed Publications

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de B. C.; Mericq, V.; ; rew, S. F.; van D. H. A.; Verkaik, N. S.; Losekoot, M.; Porollo, A.; Garcia, H.; Kuang, Y.; Hanson, D.; Clayton, P.; van G. D. C.; Wit, J. M.; Hwa, V.; Dauber,; rew; 2015. An XRCC4 splice mutation associated with severe short stature, gonadal failure, and early-onset metabolic syndrome. The Journal of clinical endocrinology and metabolism, 100 5, E789-98

Fechter, K.; Porollo, A.; 2014. MutaCYP: Classification of missense mutations in human cytochromes P450. BMC medical genomics, 7 , 47

Namjou, B.; Marsolo, K.; Caroll, R. J.; Denny, J. C.; Ritchie, M. D.; Verma, S. S.; Lingren, T.; Porollo, A.; Cobb, B. L.; Perry, C.; ra; Kottyan, L. C.; Rothenberg, M. E.; Thompson, S. D.; Holm, I. A.; Kohane, I. S.; Harley, J. B.; 2014. Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts, genetically links PLCL1 to speech language development and IL5-IL13 to Eosinophilic Esophagitis. Frontiers in genetics, 5 , 401

Porollo, A.; 2014. EC2KEGG: a command line tool for comparison of metabolic pathways. Source code for biology and medicine, 9 , 19

Porollo, A.; Sesterhenn, T. M.; Collins, M. S.; Welge, J. A.; Cushion, M. T.; 2014. Comparative genomics of pneumocystis species suggests the absence of genes for myo-inositol synthesis and reliance on inositol transport and metabolism. mBio, 5 6, e01834

Green, J. V.; Orsborn, K. I.; Zhang, M.; Tan, Q. K. G.; Greis, K. D.; Porollo, A.; ; es, D. R.; Long L. J.; Hostetter, M. K.; 2013. Heparin-binding motifs and biofilm formation by Candida albicans. The Journal of infectious diseases, 208 10, 1695-704

Hu, P.; Chen, X.; Whitener, R. J.; Boder, E. T.; Jones, J. O.; Porollo, A.; Chen, J.; Zhao, L.; 2013. Effects of parabens on adipocyte differentiation. Toxicological sciences : an official journal of the Society of Toxicology, 131 1, 56-70

Ma, L.; Tao, Y.; Duran, A.; Llado, V.; Galvez, A.; Barger, J. F.; Castilla, E. A.; Chen, J.; Yajima, T.; Porollo, A.; Medvedovic, M.; Brill, L. M.; Plas, D. R.; Riedl, S. J.; Leitges, M.; Diaz-Meco, M. T.; Richardson, A. D.; Moscat, J.; 2013. Control of nutrient stress-induced metabolic reprogramming by PKC? in tumorigenesis. Cell, 152 3, 599-611

Subramanian V. K.; L; ero F. J. A.; Porollo, A.; Caruso, J. A.; Deepe, G. S.; 2013. Granulocyte macrophage-colony stimulating factor induced Zn sequestration enhances macrophage superoxide and limits intracellular pathogen survival. Immunity, 39 4, 697-710

Subramanian V. K.; L; ero F. J. A.; Porollo, A.; Caruso, J. A.; Deepe, G. S.; 2013. Zinc sequestration: arming phagocyte defense against fungal attack. PLoS pathogens, 9 12, e1003815

Syed, K.; Porollo, A.; Lam, Y. W.; Grimmett, P. E.; Yadav, J. S.; 2013. CYP63A2, a catalytically versatile fungal P450 monooxygenase capable of oxidizing higher-molecular-weight polycyclic aromatic hydrocarbons, alkylphenols, and alkanes. Applied and environmental microbiology, 79 8, 2692-702

Syed, K.; Porollo, A.; Miller, D.; Yadav, J. S.; 2013. Rational engineering of the fungal P450 monooxygenase CYP5136A3 to improve its oxidizing activity toward polycyclic aromatic hydrocarbons. Protein engineering, design & selection : PEDS, 26 9, 553-7

Biesiada, J.; Porollo, A.; Meller, J.; 2012. On setting up and assessing docking simulations for virtual screening. Methods in molecular biology (Clifton, N.J.), 928 , 1-16

Porollo, A.; Meller, J.; Joshi, Y.; Jaiswal, V.; Smulian, A. G.; Cushion, M. T.; 2012. Analysis of current antifungal agents and their targets within the Pneumocystis carinii genome. Current drug targets, 13 12, 1575-85

Ren, K.; Lu, J.; Porollo, A.; Du, C.; 2012. Tumor-suppressing function of caspase-2 requires catalytic site Cys-320 and site Ser-139 in mice. The Journal of biological chemistry, 287 18, 14792-802

Biesiada, J.; Porollo, A.; Velayutham, P.; Kouril, M.; Meller, J.; 2011. Survey of public domain software for docking simulations and virtual screening. Human genomics, 5 5, 497-505

Duran, A.; Amanchy, R.; Linares, J. F.; Joshi, J.; Abu-Baker, S.; Porollo, A.; Hansen, M.; Moscat, J.; Diaz-Meco, M. T.; 2011. p62 is a key regulator of nutrient sensing in the mTORC1 pathway. Molecular cell, 44 1, 134-46

Giridhar, P. V.; Funk, H. M.; Gallo, C. A.; Porollo, A.; Mercer, C. A.; Plas, D. R.; Drew, A. F.; 2011. Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cells. Clinical & experimental metastasis, 28 8, 887-97

Syed, K.; Porollo, A.; Lam, Y. W.; Yadav, J. S.; 2011. A fungal P450 (CYP5136A3) capable of oxidizing polycyclic aromatic hydrocarbons and endocrine disrupting alkylphenols: role of Trp(129) and Leu(324). PloS one, 6 12, e28286

Lu, G.; Haider, H. K.; Porollo, A.; Ashraf, M.; 2010. Mitochondria-specific transgenic overexpression of connexin-43 simulates preconditioning-induced cytoprotection of stem cells. Cardiovascular research, 88 2, 277-86

Porollo, A.; Meller, J.; 2010. POLYVIEW-MM: web-based platform for animation and analysis of molecular simulations. Nucleic acids research, 38 Web Server issue, W662-6

Swaminathan, K.; Adamczak, R.; Porollo, A.; Meller, J.; 2010. Enhanced prediction of conformational flexibility and phosphorylation in proteins. Advances in experimental medicine and biology, 680 , 307-19

Cushion, M. T.; Smulian, A. G.; Slaven, B. E.; Sesterhenn, T.; Arnold, J.; Staben, C.; Porollo, A.; Adamczak, R.; Meller, J.; 2007. Transcriptome of Pneumocystis carinii during fulminate infection: carbohydrate metabolism and the concept of a compatible parasite. PloS one, 2 5, e423

Porollo, A.; Meller, J.; 2007. Versatile annotation and publication quality visualization of protein complexes using POLYVIEW-3D. BMC bioinformatics, 8 , 316

Porollo, A.; Meller, J.; 2007. Prediction-based fingerprints of protein-protein interactions. Proteins, 66 3, 630-45

Cao, B.; Porollo, A.; Adamczak, R.; Jarrell, M.; Meller, J.; 2006. Enhanced recognition of protein transmembrane domains with prediction-based structural profiles. Bioinformatics (Oxford, England), 22 3, 303-9

Slaven, B. E.; Meller, J.; Porollo, A.; Sesterhenn, T.; Smulian, A. G.; Cushion, M. T.; 2006. Draft assembly and annotation of the Pneumocystis carinii genome. The Journal of eukaryotic microbiology, 53 Suppl 1 , S89-91

Slaven, B. E.; Porollo, A.; Sesterhenn, T.; Smulian, A. G.; Cushion, M. T.; Meller, J.; 2006. Large-scale characterization of introns in the Pneumocystis carinii genome. The Journal of eukaryotic microbiology, 53 Suppl 1 , S151-3

Adamczak, R.; Porollo, A.; Meller, J.; 2005. Combining prediction of secondary structure and solvent accessibility in proteins. Proteins, 59 3, 467-75

Wagner, M.; Adamczak, R.; Porollo, A.; Meller, J.; 2005. Linear regression models for solvent accessibility prediction in proteins. Journal of computational biology : a journal of computational molecular cell biology, 12 3, 355-69

Adamczak, R.; Porollo, A.; Meller, J.; 2004. Accurate prediction of solvent accessibility using neural networks-based regression. Proteins, 56 4, 753-67

Porollo, A. A.; Adamczak, R.; Meller, J.; 2004. POLYVIEW: a flexible visualization tool for structural and functional annotations of proteins. Bioinformatics (Oxford, England), 20 15, 2460-2