Today is Wednesday, May. 4, 2016

Department of

Environmental Health

Alexey Porollo, PhD

Assistant Professor

  • Master's Degree: Mari State University
  • Doctoral Degree: Tver State University
  • Postdoctorate: Children’s Hospital Medical Center

Research/Clinical Interests

Biomedical Informatics

Contact Information
  • Cincinnati Children's Hospital Medical Center
  • 3333 Burnett Avenue
  • Cincinnati, Ohio 45267
  • Office 513-803-5489
  • Email

Peer Reviewed Publications

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de Bruin, C., Mericq, V., Andrew, S. F., van Duyvenvoorde, H. A., Verkaik, N. S., Losekoot, M., Porollo, A., Garcia, H., Kuang, Y., Hanson, D., Clayton, P., van Gent, D. C., Wit, J. M., Hwa, V., & Dauber, A. 2015. An XRCC4 splice mutation associated with severe short stature, gonadal failure, and early-onset metabolic syndrome. The Journal of Clinical Endocrinology and Metabolism, 100 5, E789-98

Fechter, K., & Porollo, A. 2014. MutaCYP: Classification of missense mutations in human cytochromes P450. BMC Medical Genomics, 7 , 47

Namjou, B., Marsolo, K., Caroll, R. J., Denny, J. C., Ritchie, M. D., Verma, S. S., Lingren, T., Porollo, A., Cobb, B. L., Perry, C., Kottyan, L. C., Rothenberg, M. E., Thompson, S. D., Holm, I. A., Kohane, I. S., & Harley, J. B. 2014. Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts, genetically links PLCL1 to speech language development and IL5-IL13 to Eosinophilic Esophagitis. Frontiers in Genetics, 5 , 401

Porollo, A., Sesterhenn, T. M., Collins, M. S., Welge, J. A., & Cushion, M. T. 2014. Comparative genomics of pneumocystis species suggests the absence of genes for myo-inositol synthesis and reliance on inositol transport and metabolism. MBio, 5 6, e01834

Porollo, Aleksey 2014. EC2KEGG: a command line tool for comparison of metabolic pathways. Source Code For Biology and Medicine, 9 , 19

Green, J. V., Orsborn, K. I., Zhang, M., Tan, Q. K. G., Greis, K. D., Porollo, A., Andes, D. R., Long Lu, J., & Hostetter, M. K. 2013. Heparin-binding motifs and biofilm formation by Candida albicans. The Journal of Infectious Diseases, 208 10, 1695-704

Hu, P., Chen, X., Whitener, R. J., Boder, E. T., Jones, J. O., Porollo, A., Chen, J., & Zhao, L. 2013. Effects of parabens on adipocyte differentiation. Toxicological Sciences : An Official Journal of the Society of Toxicology, 131 1, 56-70

Ma, L., Tao, Y., Duran, A., Llado, V., Galvez, A., Barger, J. F., Castilla, E. A., Chen, J., Yajima, T., Porollo, A., Medvedovic, M., Brill, L. M., Plas, D. R., Riedl, S. J., Leitges, M., Diaz-Meco, M. T., Richardson, A. D., & Moscat, J. 2013. Control of nutrient stress-induced metabolic reprogramming by PKC? in tumorigenesis. Cell, 152 3, 599-611

Subramanian Vignesh, K., Landero Figueroa, J. A., Porollo, A., Caruso, J. A., & Deepe, G. S. 2013. Granulocyte macrophage-colony stimulating factor induced Zn sequestration enhances macrophage superoxide and limits intracellular pathogen survival. Immunity, 39 4, 697-710

Subramanian Vignesh, K., Landero Figueroa, J. A., Porollo, A., Caruso, J. A., & Deepe, G. S. 2013. Zinc sequestration: arming phagocyte defense against fungal attack. PLoS Pathogens, 9 12, e1003815

Syed, K., Porollo, A., Lam, Y. W., Grimmett, P. E., & Yadav, J. S. 2013. CYP63A2, a catalytically versatile fungal P450 monooxygenase capable of oxidizing higher-molecular-weight polycyclic aromatic hydrocarbons, alkylphenols, and alkanes. Applied and Environmental Microbiology, 79 8, 2692-702

Syed, K., Porollo, A., Miller, D., & Yadav, J. S. 2013. Rational engineering of the fungal P450 monooxygenase CYP5136A3 to improve its oxidizing activity toward polycyclic aromatic hydrocarbons. Protein Engineering, Design & Selection : PEDS, 26 9, 553-7

Biesiada, J., Porollo, A., & Meller, J. 2012. On setting up and assessing docking simulations for virtual screening. Methods in Molecular Biology (Clifton, N.J.), 928 , 1-16

Porollo, A., Meller, J., Joshi, Y., Jaiswal, V., Smulian, A. G., & Cushion, M. T. 2012. Analysis of current antifungal agents and their targets within the Pneumocystis carinii genome. Current Drug Targets, 13 12, 1575-85

Ren, K., Lu, J., Porollo, A., & Du, C. 2012. Tumor-suppressing function of caspase-2 requires catalytic site Cys-320 and site Ser-139 in mice. The Journal of Biological Chemistry, 287 18, 14792-802

Biesiada, J., Porollo, A., Velayutham, P., Kouril, M., & Meller, J. 2011. Survey of public domain software for docking simulations and virtual screening. Human Genomics, 5 5, 497-505

Duran, A., Amanchy, R., Linares, J. F., Joshi, J., Abu-Baker, S., Porollo, A., Hansen, M., Moscat, J., & Diaz-Meco, M. T. 2011. p62 is a key regulator of nutrient sensing in the mTORC1 pathway. Molecular Cell, 44 1, 134-46

Giridhar, P. V., Funk, H. M., Gallo, C. A., Porollo, A., Mercer, C. A., Plas, D. R., & Drew, A. F. 2011. Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cells. Clinical & Experimental Metastasis, 28 8, 887-97

Syed, K., Porollo, A., Lam, Y. W., & Yadav, J. S. 2011. A fungal P450 (CYP5136A3) capable of oxidizing polycyclic aromatic hydrocarbons and endocrine disrupting alkylphenols: role of Trp(129) and Leu(324). PloS One, 6 12, e28286

Lu, G., Haider, H. K., Porollo, A., & Ashraf, M. 2010. Mitochondria-specific transgenic overexpression of connexin-43 simulates preconditioning-induced cytoprotection of stem cells. Cardiovascular Research, 88 2, 277-86

Porollo, A., & Meller, J. 2010. POLYVIEW-MM: web-based platform for animation and analysis of molecular simulations. Nucleic Acids Research, 38 Web Server issue, W662-6

Swaminathan, K., Adamczak, R., Porollo, A., & Meller, J. 2010. Enhanced prediction of conformational flexibility and phosphorylation in proteins. Advances in Experimental Medicine and Biology, 680 , 307-19

Cushion, M. T., Smulian, A. G., Slaven, B. E., Sesterhenn, T., Arnold, J., Staben, C., Porollo, A., Adamczak, R., & Meller, J. 2007. Transcriptome of Pneumocystis carinii during fulminate infection: carbohydrate metabolism and the concept of a compatible parasite. PloS One, 2 5, e423

Porollo, A., & Meller, J. 2007. Versatile annotation and publication quality visualization of protein complexes using POLYVIEW-3D. BMC Bioinformatics, 8 , 316

Porollo, A., & Meller, J. 2007. Prediction-based fingerprints of protein-protein interactions. Proteins, 66 3, 630-45

Cao, B., Porollo, A., Adamczak, R., Jarrell, M., & Meller, J. 2006. Enhanced recognition of protein transmembrane domains with prediction-based structural profiles. Bioinformatics (Oxford, England), 22 3, 303-9

Slaven, B. E., Meller, J., Porollo, A., Sesterhenn, T., Smulian, A. G., & Cushion, M. T. 2006. Draft assembly and annotation of the Pneumocystis carinii genome. The Journal of Eukaryotic Microbiology, 53 Suppl 1 , S89-91

Slaven, B. E., Porollo, A., Sesterhenn, T., Smulian, A. G., Cushion, M. T., & Meller, J. 2006. Large-scale characterization of introns in the Pneumocystis carinii genome. The Journal of Eukaryotic Microbiology, 53 Suppl 1 , S151-3

Adamczak, R., Porollo, A., & Meller, J. 2005. Combining prediction of secondary structure and solvent accessibility in proteins. Proteins, 59 3, 467-75

Wagner, M., Adamczak, R., Porollo, A., & Meller, J. 2005. Linear regression models for solvent accessibility prediction in proteins. Journal of Computational Biology : A Journal of Computational Molecular Cell Biology, 12 3, 355-69

Adamczak, R., Porollo, A., & Meller, J. 2004. Accurate prediction of solvent accessibility using neural networks-based regression. Proteins, 56 4, 753-67

Porollo, A. A., Adamczak, R., & Meller, J. 2004. POLYVIEW: a flexible visualization tool for structural and functional annotations of proteins. Bioinformatics (Oxford, England), 20 15, 2460-2