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Department of

Environmental Health

Photo of  Alexey Porollo, PhD

Alexey Porollo, PhD

Assistant Professor

  • Master's Degree: Mari State University
  • Doctoral Degree: Tver State University
  • Postdoctorate: Children’s Hospital Medical Center

Research/Clinical Interests

Biomedical Informatics

Contact Information
  • Cincinnati Children's Hospital Medical Center
  • 3333 Burnett Avenue
  • Cincinnati, Ohio 45267
  • Office 513-803-5489
  • Email

Peer Reviewed Publications

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de Bruin, Christiaan; Mericq, Verónica; Andrew, Shayne F; van Duyvenvoorde, Hermine A; Verkaik, Nicole S; Losekoot, Monique; Porollo, Aleksey; Garcia, Hernán; Kuang, Yi; Hanson, Dan; Clayton, Peter; van Gent, Dik C; Wit, Jan M; Hwa, Vivian; Dauber, Andrew 2015. An XRCC4 splice mutation associated with severe short stature, gonadal failure, and early-onset metabolic syndrome. The Journal of clinical endocrinology and metabolism, 100 5, E789-98

Fechter, Kenneth; Porollo, Aleksey 2014. MutaCYP: Classification of missense mutations in human cytochromes P450. BMC medical genomics, 7 , 47

Namjou, Bahram; Marsolo, Keith; Caroll, Robert J; Denny, Joshua C; Ritchie, Marylyn D; Verma, Shefali S; Lingren, Todd; Porollo, Aleksey; Cobb, Beth L; Perry, Cassandra; Kottyan, Leah C; Rothenberg, Marc E; Thompson, Susan D; Holm, Ingrid A; Kohane, Isaac S; Harley, John B 2014. Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts, genetically links PLCL1 to speech language development and IL5-IL13 to Eosinophilic Esophagitis. Frontiers in genetics, 5 , 401

Porollo, Aleksey 2014. EC2KEGG: a command line tool for comparison of metabolic pathways. Source code for biology and medicine, 9 , 19

Porollo, Aleksey; Sesterhenn, Thomas M; Collins, Margaret S; Welge, Jeffrey A; Cushion, Melanie T 2014. Comparative genomics of pneumocystis species suggests the absence of genes for myo-inositol synthesis and reliance on inositol transport and metabolism. mBio, 5 6, e01834

Green, Julianne V; Orsborn, Kris I; Zhang, Minlu; Tan, Queenie K G; Greis, Kenneth D; Porollo, Alexey; Andes, David R; Long Lu, Jason; Hostetter, Margaret K 2013. Heparin-binding motifs and biofilm formation by Candida albicans. The Journal of infectious diseases, 208 10, 1695-704

Hu, Pan; Chen, Xin; Whitener, Rick J; Boder, Eric T; Jones, Jeremy O; Porollo, Aleksey; Chen, Jiangang; Zhao, Ling 2013. Effects of parabens on adipocyte differentiation. Toxicological sciences : an official journal of the Society of Toxicology, 131 1, 56-70

Ma, Li; Tao, Yongzhen; Duran, Angeles; Llado, Victoria; Galvez, Anita; Barger, Jennifer F; Castilla, Elias A; Chen, Jing; Yajima, Tomoko; Porollo, Aleksey; Medvedovic, Mario; Brill, Laurence M; Plas, David R; Riedl, Stefan J; Leitges, Michael; Diaz-Meco, Maria T; Richardson, Adam D; Moscat, Jorge 2013. Control of nutrient stress-induced metabolic reprogramming by PKC? in tumorigenesis. Cell, 152 3, 599-611

Subramanian Vignesh, Kavitha; Landero Figueroa, Julio A; Porollo, Aleksey; Caruso, Joseph A; Deepe, George S 2013. Granulocyte macrophage-colony stimulating factor induced Zn sequestration enhances macrophage superoxide and limits intracellular pathogen survival. Immunity, 39 4, 697-710

Subramanian Vignesh, Kavitha; Landero Figueroa, Julio A; Porollo, Aleksey; Caruso, Joseph A; Deepe, George S 2013. Zinc sequestration: arming phagocyte defense against fungal attack. PLoS pathogens, 9 12, e1003815

Syed, Khajamohiddin; Porollo, Aleksey; Lam, Ying Wai; Grimmett, Paul E; Yadav, Jagjit S 2013. CYP63A2, a catalytically versatile fungal P450 monooxygenase capable of oxidizing higher-molecular-weight polycyclic aromatic hydrocarbons, alkylphenols, and alkanes. Applied and environmental microbiology, 79 8, 2692-702

Syed, Khajamohiddin; Porollo, Aleksey; Miller, David; Yadav, Jagjit S 2013. Rational engineering of the fungal P450 monooxygenase CYP5136A3 to improve its oxidizing activity toward polycyclic aromatic hydrocarbons. Protein engineering, design & selection : PEDS, 26 9, 553-7

Biesiada, Jacek; Porollo, Aleksey; Meller, Jaroslaw 2012. On setting up and assessing docking simulations for virtual screening. Methods in molecular biology (Clifton, N.J.), 928 , 1-16

Porollo, Aleksey; Meller, Jaroslaw; Joshi, Yogesh; Jaiswal, Vikash; Smulian, A George; Cushion, Melanie T 2012. Analysis of current antifungal agents and their targets within the Pneumocystis carinii genome. Current drug targets, 13 12, 1575-85

Ren, Keqin; Lu, Jing; Porollo, Aleksey; Du, Chunying 2012. Tumor-suppressing function of caspase-2 requires catalytic site Cys-320 and site Ser-139 in mice. The Journal of biological chemistry, 287 18, 14792-802

Biesiada, Jacek; Porollo, Aleksey; Velayutham, Prakash; Kouril, Michal; Meller, Jaroslaw 2011. Survey of public domain software for docking simulations and virtual screening. Human genomics, 5 5, 497-505

Duran, Angeles; Amanchy, Ramars; Linares, Juan F; Joshi, Jayashree; Abu-Baker, Shadi; Porollo, Aleksey; Hansen, Malene; Moscat, Jorge; Diaz-Meco, Maria T 2011. p62 is a key regulator of nutrient sensing in the mTORC1 pathway. Molecular cell, 44 1, 134-46

Giridhar, Premkumar Vummidi; Funk, Holly M; Gallo, Catherine A; Porollo, Aleksey; Mercer, Carol A; Plas, David R; Drew, Angela F 2011. Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cells. Clinical & experimental metastasis, 28 8, 887-97

Syed, Khajamohiddin; Porollo, Aleksey; Lam, Ying Wai; Yadav, Jagjit S 2011. A fungal P450 (CYP5136A3) capable of oxidizing polycyclic aromatic hydrocarbons and endocrine disrupting alkylphenols: role of Trp(129) and Leu(324). PloS one, 6 12, e28286

Lu, Gang; Haider, Husnain Kh; Porollo, Aleksey; Ashraf, Muhammad 2010. Mitochondria-specific transgenic overexpression of connexin-43 simulates preconditioning-induced cytoprotection of stem cells. Cardiovascular research, 88 2, 277-86

Porollo, Aleksey; Meller, Jaroslaw 2010. POLYVIEW-MM: web-based platform for animation and analysis of molecular simulations. Nucleic acids research, 38 Web Server issue, W662-6

Swaminathan, Karthikeyan; Adamczak, Rafal; Porollo, Aleksey; Meller, Jaros?aw 2010. Enhanced prediction of conformational flexibility and phosphorylation in proteins. Advances in experimental medicine and biology, 680 , 307-19

Cushion, Melanie T; Smulian, A George; Slaven, Bradley E; Sesterhenn, Tom; Arnold, Jonathan; Staben, Chuck; Porollo, Aleksey; Adamczak, Rafal; Meller, Jarek 2007. Transcriptome of Pneumocystis carinii during fulminate infection: carbohydrate metabolism and the concept of a compatible parasite. PloS one, 2 5, e423

Porollo, Aleksey; Meller, Jaros?aw 2007. Prediction-based fingerprints of protein-protein interactions. Proteins, 66 3, 630-45

Porollo, Aleksey; Meller, Jaroslaw 2007. Versatile annotation and publication quality visualization of protein complexes using POLYVIEW-3D. BMC bioinformatics, 8 , 316

Cao, Baoqiang; Porollo, Aleksey; Adamczak, Rafal; Jarrell, Mark; Meller, Jaroslaw 2006. Enhanced recognition of protein transmembrane domains with prediction-based structural profiles. Bioinformatics (Oxford, England), 22 3, 303-9

Slaven, Bradley E; Meller, Jaroslaw; Porollo, Aleksey; Sesterhenn, Thomas; Smulian, A George; Cushion, Melanie T 2006. Draft assembly and annotation of the Pneumocystis carinii genome. The Journal of eukaryotic microbiology, 53 Suppl 1 , S89-91

Slaven, Bradley E; Porollo, Aleksey; Sesterhenn, Thomas; Smulian, A George; Cushion, Melanie T; Meller, Jaroslaw 2006. Large-scale characterization of introns in the Pneumocystis carinii genome. The Journal of eukaryotic microbiology, 53 Suppl 1 , S151-3

Adamczak, Rafa?; Porollo, Aleksey; Meller, Jaros?aw 2005. Combining prediction of secondary structure and solvent accessibility in proteins. Proteins, 59 3, 467-75

Wagner, Michael; Adamczak, Rafa?; Porollo, Aleksey; Meller, Jaros?aw 2005. Linear regression models for solvent accessibility prediction in proteins. Journal of computational biology : a journal of computational molecular cell biology, 12 3, 355-69

Adamczak, Rafa?; Porollo, Aleksey; Meller, Jaros?aw 2004. Accurate prediction of solvent accessibility using neural networks-based regression. Proteins, 56 4, 753-67

Porollo, Aleksey A; Adamczak, Rafal; Meller, Jaroslaw 2004. POLYVIEW: a flexible visualization tool for structural and functional annotations of proteins. Bioinformatics (Oxford, England), 20 15, 2460-2