Today is Saturday, Feb. 6, 2016

Department of

Environmental Health

Alexey Porollo, PhD

Assistant Professor

Education/Credentials
  • Master's Degree: Mari State University
  • Doctoral Degree: Tver State University
  • Postdoctorate: Children’s Hospital Medical Center

Research/Clinical Interests

Biomedical Informatics

Contact Information
  • Kettering Laboratory
  • 160 Panzeca Way
  • Cincinnati, Ohio 45267
  • Office 513-803-5489
  • Email alexey.porollo@uc.edu

Peer Reviewed Publications

Display All

de Bruin, C., Mericq, V., Andrew, S. F., van Duyvenvoorde, H. A., Verkaik, N. S., Losekoot, M., Porollo, A., Garcia, H., Kuang, Y., Hanson, D., Clayton, P., van Gent, D. C., Wit, J. M., Hwa, V., & Dauber, A. 2015. An XRCC4 splice mutation associated with severe short stature, gonadal failure, and early-onset metabolic syndrome. The Journal of Clinical Endocrinology and Metabolism, 100 5, E789-98

Fechter, K., & Porollo, A. 2014. MutaCYP: Classification of missense mutations in human cytochromes P450. BMC Medical Genomics, 7 , 47

Namjou, B., Marsolo, K., Caroll, R. J., Denny, J. C., Ritchie, M. D., Verma, S. S., Lingren, T., Porollo, A., Cobb, B. L., Perry, C., Kottyan, L. C., Rothenberg, M. E., Thompson, S. D., Holm, I. A., Kohane, I. S., & Harley, J. B. 2014. Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts, genetically links PLCL1 to speech language development and IL5-IL13 to Eosinophilic Esophagitis. Frontiers in Genetics, 5 , 401

Porollo, A., Sesterhenn, T. M., Collins, M. S., Welge, J. A., & Cushion, M. T. 2014. Comparative genomics of pneumocystis species suggests the absence of genes for myo-inositol synthesis and reliance on inositol transport and metabolism. MBio, 5 6, e01834

Porollo, Aleksey 2014. EC2KEGG: a command line tool for comparison of metabolic pathways. Source Code For Biology and Medicine, 9 , 19

Green, J. V., Orsborn, K. I., Zhang, M., Tan, Q. K. G., Greis, K. D., Porollo, A., Andes, D. R., Long Lu, J., & Hostetter, M. K. 2013. Heparin-binding motifs and biofilm formation by Candida albicans. The Journal of Infectious Diseases, 208 10, 1695-704

Hu, P., Chen, X., Whitener, R. J., Boder, E. T., Jones, J. O., Porollo, A., Chen, J., & Zhao, L. 2013. Effects of parabens on adipocyte differentiation. Toxicological Sciences : An Official Journal of the Society of Toxicology, 131 1, 56-70

Ma, L., Tao, Y., Duran, A., Llado, V., Galvez, A., Barger, J. F., Castilla, E. A., Chen, J., Yajima, T., Porollo, A., Medvedovic, M., Brill, L. M., Plas, D. R., Riedl, S. J., Leitges, M., Diaz-Meco, M. T., Richardson, A. D., & Moscat, J. 2013. Control of nutrient stress-induced metabolic reprogramming by PKC? in tumorigenesis. Cell, 152 3, 599-611

Subramanian Vignesh, K., Landero Figueroa, J. A., Porollo, A., Caruso, J. A., & Deepe, G. S. 2013. Granulocyte macrophage-colony stimulating factor induced Zn sequestration enhances macrophage superoxide and limits intracellular pathogen survival. Immunity, 39 4, 697-710

Subramanian Vignesh, K., Landero Figueroa, J. A., Porollo, A., Caruso, J. A., & Deepe, G. S. 2013. Zinc sequestration: arming phagocyte defense against fungal attack. PLoS Pathogens, 9 12, e1003815

Syed, K., Porollo, A., Lam, Y. W., Grimmett, P. E., & Yadav, J. S. 2013. CYP63A2, a catalytically versatile fungal P450 monooxygenase capable of oxidizing higher-molecular-weight polycyclic aromatic hydrocarbons, alkylphenols, and alkanes. Applied and Environmental Microbiology, 79 8, 2692-702

Syed, K., Porollo, A., Miller, D., & Yadav, J. S. 2013. Rational engineering of the fungal P450 monooxygenase CYP5136A3 to improve its oxidizing activity toward polycyclic aromatic hydrocarbons. Protein Engineering, Design & Selection : PEDS, 26 9, 553-7

Biesiada, J., Porollo, A., & Meller, J. 2012. On setting up and assessing docking simulations for virtual screening. Methods in Molecular Biology (Clifton, N.J.), 928 , 1-16

Porollo, A., Meller, J., Joshi, Y., Jaiswal, V., Smulian, A. G., & Cushion, M. T. 2012. Analysis of current antifungal agents and their targets within the Pneumocystis carinii genome. Current Drug Targets, 13 12, 1575-85

Ren, K., Lu, J., Porollo, A., & Du, C. 2012. Tumor-suppressing function of caspase-2 requires catalytic site Cys-320 and site Ser-139 in mice. The Journal of Biological Chemistry, 287 18, 14792-802

Biesiada, J., Porollo, A., Velayutham, P., Kouril, M., & Meller, J. 2011. Survey of public domain software for docking simulations and virtual screening. Human Genomics, 5 5, 497-505

Duran, A., Amanchy, R., Linares, J. F., Joshi, J., Abu-Baker, S., Porollo, A., Hansen, M., Moscat, J., & Diaz-Meco, M. T. 2011. p62 is a key regulator of nutrient sensing in the mTORC1 pathway. Molecular Cell, 44 1, 134-46

Giridhar, P. V., Funk, H. M., Gallo, C. A., Porollo, A., Mercer, C. A., Plas, D. R., & Drew, A. F. 2011. Interleukin-6 receptor enhances early colonization of the murine omentum by upregulation of a mannose family receptor, LY75, in ovarian tumor cells. Clinical & Experimental Metastasis, 28 8, 887-97

Syed, K., Porollo, A., Lam, Y. W., & Yadav, J. S. 2011. A fungal P450 (CYP5136A3) capable of oxidizing polycyclic aromatic hydrocarbons and endocrine disrupting alkylphenols: role of Trp(129) and Leu(324). PloS One, 6 12, e28286

Lu, G., Haider, H. K., Porollo, A., & Ashraf, M. 2010. Mitochondria-specific transgenic overexpression of connexin-43 simulates preconditioning-induced cytoprotection of stem cells. Cardiovascular Research, 88 2, 277-86

Porollo, A., & Meller, J. 2010. POLYVIEW-MM: web-based platform for animation and analysis of molecular simulations. Nucleic Acids Research, 38 Web Server issue, W662-6

Swaminathan, K., Adamczak, R., Porollo, A., & Meller, J. 2010. Enhanced prediction of conformational flexibility and phosphorylation in proteins. Advances in Experimental Medicine and Biology, 680 , 307-19

Cushion, M. T., Smulian, A. G., Slaven, B. E., Sesterhenn, T., Arnold, J., Staben, C., Porollo, A., Adamczak, R., & Meller, J. 2007. Transcriptome of Pneumocystis carinii during fulminate infection: carbohydrate metabolism and the concept of a compatible parasite. PloS One, 2 5, e423

Porollo, A., & Meller, J. 2007. Versatile annotation and publication quality visualization of protein complexes using POLYVIEW-3D. BMC Bioinformatics, 8 , 316

Porollo, A., & Meller, J. 2007. Prediction-based fingerprints of protein-protein interactions. Proteins, 66 3, 630-45

Cao, B., Porollo, A., Adamczak, R., Jarrell, M., & Meller, J. 2006. Enhanced recognition of protein transmembrane domains with prediction-based structural profiles. Bioinformatics (Oxford, England), 22 3, 303-9

Slaven, B. E., Meller, J., Porollo, A., Sesterhenn, T., Smulian, A. G., & Cushion, M. T. 2006. Draft assembly and annotation of the Pneumocystis carinii genome. The Journal of Eukaryotic Microbiology, 53 Suppl 1 , S89-91

Slaven, B. E., Porollo, A., Sesterhenn, T., Smulian, A. G., Cushion, M. T., & Meller, J. 2006. Large-scale characterization of introns in the Pneumocystis carinii genome. The Journal of Eukaryotic Microbiology, 53 Suppl 1 , S151-3

Adamczak, R., Porollo, A., & Meller, J. 2005. Combining prediction of secondary structure and solvent accessibility in proteins. Proteins, 59 3, 467-75

Wagner, M., Adamczak, R., Porollo, A., & Meller, J. 2005. Linear regression models for solvent accessibility prediction in proteins. Journal of Computational Biology : A Journal of Computational Molecular Cell Biology, 12 3, 355-69

Adamczak, R., Porollo, A., & Meller, J. 2004. Accurate prediction of solvent accessibility using neural networks-based regression. Proteins, 56 4, 753-67

Porollo, A. A., Adamczak, R., & Meller, J. 2004. POLYVIEW: a flexible visualization tool for structural and functional annotations of proteins. Bioinformatics (Oxford, England), 20 15, 2460-2