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Department of

Environmental Health

Photo of Susan Kasper, PhD

Susan Kasper, PhD

Professor, Department of Environmental Health, UC College of Medicine

Education/Credentials
  • B.Sc. Honours: University of Manitoba
  • M.S.: University of Manitoba
  • Ph.D.: University of Manitoba

Contact Information
  • Department of Environmental Health
  • Kettering Laboratory
  • Office 513-558-2126
  • Email Susan.Kasper@uc.edu

Peer Reviewed Publications

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Vummidi Giridhar, Premkumar; Williams, Karin; VonHandorf, Andrew P; Deford, Paul L; Kasper, Susan 2019. Constant Degradation of the Androgen Receptor by MDM2 Conserves Prostate Cancer Stem Cell Integrity. Cancer research, 79 6, 1124-1137

Langevin, Scott; Kuhnell, Damaris; Parry, Tess; Biesiada, Jacek; Huang, Shouxiong; Wise-Draper, Trisha; Casper, Keith; Zhang, Xiang; Medvedovic, Mario; Kasper, Susan 2017. Comprehensive microRNA-sequencing of exosomes derived from head and neck carcinoma cells in vitro reveals common secretion profiles and potential utility as salivary biomarkers. Oncotarget, 8 47, 82459-82474

Varughese, Eunice A; Kasper, Susan; Anneken, Emily M; Yadav, Jagjit S 2015. SHP-2 Mediates Cryptosporidium parvum Infectivity in Human Intestinal Epithelial Cells. PloS one, 10 11, e0142219

Zhou, Jian; Giridhar, Premkumar Vummidi; Kasper, Susan; Papautsky, Ian 2014. Modulation of rotation-induced lift force for cell filtration in a low aspect ratio microchannel. Biomicrofluidics, 8 4, 044112

Cai, Yuqi; Balli, David; Ustiyan, Vladimir; Fulford, Logan; Hiller, Andrea; Misetic, Vinko; Zhang, Yufang; Paluch, Andrew M; Waltz, Susan E; Kasper, Susan; Kalin, Tanya V 2013. Foxm1 expression in prostate epithelial cells is essential for prostate carcinogenesis. The Journal of biological chemistry, 288 31, 22527-41

Zhou, Jian; Giridhar, Premkumar Vummidi; Kasper, Susan; Papautsky, Ian 2013. Modulation of aspect ratio for complete separation in an inertial microfluidic channel. Lab on a chip, 13 10, 1919-29

Zhou, Jian; Kasper, Susan; Papautsky, Ian 2013. Enhanced size-dependent trapping of particles using microvortices. Microfluidics and nanofluidics, 15 5,

Kendig, Eric L; Buesing, Dana R; Christie, Susie M; Cookman, Clifford J; Gear, Robin B; Hugo, Eric R; Kasper, Susan N; Kendziorski, Jessica A; Ungi, Kevin R; Williams, Karin; Belcher, Scott M 2012. Estrogen-like disruptive effects of dietary exposure to bisphenol A or 17α-ethinyl estradiol in CD1 mice. International journal of toxicology, 31 6, 537-50

Williams, Karin; Ghosh, Ritwik; Giridhar, Premkumar Vummidi; Gu, Guangyu; Case, Thomas; Belcher, Scott M; Kasper, Susan 2012. Inhibition of stathmin1 accelerates the metastatic process. Cancer research, 72 20, 5407-17

Liu, June; Pascal, Laura E; Isharwal, Sudhir; Metzger, Daniel; Ramos Garcia, Raquel; Pilch, Jan; Kasper, Susan; Williams, Karin; Basse, Per H; Nelson, Joel B; Chambon, Pierre; Wang, Zhou 2011. Regenerated luminal epithelial cells are derived from preexisting luminal epithelial cells in adult mouse prostate. Molecular endocrinology (Baltimore, Md.), 25 11, 1849-57

Zhang, JianFeng; Gao, Nan; DeGraff, David J; Yu, Xiuping; Sun, Qian; Case, Thomas C; Kasper, Susan; Matusik, Robert J 2010. Characterization of cis elements of the probasin promoter necessary for prostate-specific gene expression. The Prostate, 70 9, 934-51

Chaurand, Pierre; Rahman, Mohammad A; Hunt, Tamela; Mobley, James A; Gu, Guangyu; Latham, Joey C; Caprioli, Richard M; Kasper, Susan 2008. Monitoring mouse prostate development by profiling and imaging mass spectrometry. Molecular & cellular proteomics : MCP, 7 2, 411-23

Ghosh, Ritwik; Gu, Guangyu; Tillman, Erin; Yuan, Jialing; Wang, Yongqing; Fazli, Ladan; Rennie, Paul S; Kasper, Susan 2007. Increased expression and differential phosphorylation of stathmin may promote prostate cancer progression. The Prostate, 67 10, 1038-52

Gipp, Jerry; Gu, Guangyu; Crylen, Curtis; Kasper, Susan; Bushman, Wade 2007. Hedgehog pathway activity in the LADY prostate tumor model. Molecular cancer, 6 , 19

Gu, Guangyu; Yuan, Jialing; Wills, Marcia; Kasper, Susan 2007. Prostate cancer cells with stem cell characteristics reconstitute the original human tumor in vivo. Cancer research, 67 10, 4807-15

Tillman, J Erin; Yuan, Jialing; Gu, Guangyu; Fazli, Ladan; Ghosh, Ritwik; Flynt, Alex S; Gleave, Martin; Rennie, Paul S; Kasper, Susan 2007. DJ-1 binds androgen receptor directly and mediates its activity in hormonally treated prostate cancer cells. Cancer research, 67 10, 4630-7

Pitkänen-Arsiola, Tiina; Tillman, J Erin; Gu, Guangyu; Yuan, Jialing; Roberts, Richard L; Wantroba, Marcus; Coetzee, Gerhard A; Cookson, Michael S; Kasper, Susan 2006. Androgen and anti-androgen treatment modulates androgen receptor activity and DJ-1 stability. The Prostate, 66 11, 1177-93

Wang, Yongqing; Kasper, Susan; Yuan, Jialing; Jin, Ren Jie; Zhang, Jianfeng; Ishii, Kenichiro; Wills, Marcia L; Hayward, Simon W; Matusik, Robert J 2006. Androgen-dependent prostate epithelial cell selection by targeting ARR(2)PBneo to the LPB-Tag model of prostate cancer. Laboratory investigation; a journal of technical methods and pathology, 86 10, 1074-88

Jin, Ren Jie; Wang, Yongqing; Masumori, Naoya; Ishii, Kenichiro; Tsukamoto, Taiji; Shappell, Scott B; Hayward, Simon W; Kasper, Susan; Matusik, Robert J 2004. NE-10 neuroendocrine cancer promotes the LNCaP xenograft growth in castrated mice. Cancer research, 64 15, 5489-95

Masumori, Naoya; Tsuchiya, Karen; Tu, William H; Lee, Charles; Kasper, Susan; Tsukamoto, Taiji; Shappell, Scott B; Matusik, Robert J 2004. An allograft model of androgen independent prostatic neuroendocrine carcinoma derived from a large probasin promoter-T antigen transgenic mouse line. The Journal of urology, 171 1, 439-42

Zhang, JianFeng; Gao, Nan; Kasper, Susan; Reid, Kimberly; Nelson, Colleen; Matusik, Robert J 2004. An androgen-dependent upstream enhancer is essential for high levels of probasin gene expression. Endocrinology, 145 1, 134-48

Tu, William H; Thomas, Tania Z; Masumori, Naoya; Bhowmick, Neil A; Gorska, Agnieszka E; Shyr, Yu; Kasper, Susan; Case, Tom; Roberts, Richard L; Shappell, Scott B; Moses, Harold L; Matusik, Robert J 2003. The loss of TGF-beta signaling promotes prostate cancer metastasis. Neoplasia (New York, N.Y.), 5 3, 267-77

Zhang, Ye; Yu, Jiang; Unni, Emmanual; Shao, Tsang C; Nan, Bicheng; Snabboon, Thiti; Kasper, Susan; Andriani, Francesca; Denner, Larry; Marcelli, Marco 2002. Monogene and polygene therapy for the treatment of experimental prostate cancers by use of apoptotic genes bax and bad driven by the prostate-specific promoter ARR(2)PB. Human gene therapy, 13 17, 2051-64

Chaurand, P; DaGue, B B; Ma, S; Kasper, S; Caprioli, R M 2001. Strain-based sequence variations and structure analysis of murine prostate specific spermine binding protein using mass spectrometry. Biochemistry, 40 32, 9725-33

Lareyre, J J; Winfrey, V P; Kasper, S; Ong, D E; Matusik, R J; Olson, G E; Orgebin-Crist, M C 2001. Gene duplication gives rise to a new 17-kilodalton lipocalin that shows epididymal region-specific expression and testicular factor(s) regulation. Endocrinology, 142 3, 1296-308

Masumori, N; Thomas, T Z; Chaurand, P; Case, T; Paul, M; Kasper, S; Caprioli, R M; Tsukamoto, T; Shappell, S B; Matusik, R J 2001. A probasin-large T antigen transgenic mouse line develops prostate adenocarcinoma and neuroendocrine carcinoma with metastatic potential. Cancer research, 61 5, 2239-49

Kasper, S; Matusik, R J 2000. Rat probasin: structure and function of an outlier lipocalin. Biochimica et biophysica acta, 1482 1-2, 249-58

Lareyre, J J; Reid, K; Nelson, C; Kasper, S; Rennie, P S; Orgebin-Crist, M C; Matusik, R J 2000. Characterization of an androgen-specific response region within the 5' flanking region of the murine epididymal retinoic acid binding protein gene. Biology of reproduction, 63 6, 1881-92

Zhang, J; Thomas, T Z; Kasper, S; Matusik, R J 2000. A small composite probasin promoter confers high levels of prostate-specific gene expression through regulation by androgens and glucocorticoids in vitro and in vivo. Endocrinology, 141 12, 4698-710

Brash, A R; Jisaka, M; Boeglin, W E; Chang, M S; Keeney, D S; Nanney, L B; Kasper, S; Matusik, R J; Olson, S J; Shappell, S B 1999. Investigation of a second 15S-lipoxygenase in humans and its expression in epithelial tissues. Advances in experimental medicine and biology, 469 , 83-9

Kasper, S; Rennie, P S; Bruchovsky, N; Lin, L; Cheng, H; Snoek, R; Dahlman-Wright, K; Gustafsson, J A; Shiu, R P; Sheppard, P C; Matusik, R J 1999. Selective activation of the probasin androgen-responsive region by steroid hormones. Journal of molecular endocrinology, 22 3, 313-25

Lareyre, J J; Thomas, T Z; Zheng, W L; Kasper, S; Ong, D E; Orgebin-Crist, M C; Matusik, R J 1999. A 5-kilobase pair promoter fragment of the murine epididymal retinoic acid-binding protein gene drives the tissue-specific, cell-specific, and androgen-regulated expression of a foreign gene in the epididymis of transgenic mice. The Journal of biological chemistry, 274 12, 8282-90

Shappell, S B; Boeglin, W E; Olson, S J; Kasper, S; Brash, A R 1999. 15-lipoxygenase-2 (15-LOX-2) is expressed in benign prostatic epithelium and reduced in prostate adenocarcinoma. The American journal of pathology, 155 1, 235-45

Kasper, S; Sheppard, P C; Yan, Y; Pettigrew, N; Borowsky, A D; Prins, G S; Dodd, J G; Duckworth, M L; Matusik, R J 1998. Development, progression, and androgen-dependence of prostate tumors in probasin-large T antigen transgenic mice: a model for prostate cancer. Laboratory investigation; a journal of technical methods and pathology, 78 6, i-xv

Lareyre, J J; Mattéi, M G; Kasper, S; Newcomer, M E; Ong, D E; Matusik, R J; Orgebin-Crist, M C 1998. Structure and putative function of a murine epididymal retinoic acid-binding protein (mE-RABP). Journal of reproduction and fertility. Supplement, 53 , 59-65

Lareyre, J J; Mattéi, M G; Kasper, S; Ong, D E; Matusik, R J; Orgebin-Crist, M C 1998. Genomic organization and chromosomal localization of the murine epididymal retinoic acid-binding protein (mE-RABP) gene. Molecular reproduction and development, 50 4, 387-95

Lareyre, J J; Zheng, W L; Zhao, G Q; Kasper, S; Newcomer, M E; Matusik, R J; Ong, D E; Orgebin-Crist, M C 1998. Molecular cloning and hormonal regulation of a murine epididymal retinoic acid-binding protein messenger ribonucleic acid. Endocrinology, 139 6, 2971-81

Metts, J C; Kotkin, L; Kasper, S; Shyr, Y; Adams, M C; Brock, J W 1997. Genital malformations and coexistent urinary tract or spinal anomalies in patients with imperforate anus. The Journal of urology, 158 3 Pt 2, 1298-300

Yan, Y; Sheppard, P C; Kasper, S; Lin, L; Hoare, S; Kapoor, A; Dodd, J G; Duckworth, M L; Matusik, R J 1997. Large fragment of the probasin promoter targets high levels of transgene expression to the prostate of transgenic mice. The Prostate, 32 2, 129-39

Kasper, S; Rennie, P S; Bruchovsky, N; Sheppard, P C; Cheng, H; Lin, L; Shiu, R P; Snoek, R; Matusik, R J 1994. Cooperative binding of androgen receptors to two DNA sequences is required for androgen induction of the probasin gene. The Journal of biological chemistry, 269 50, 31763-9

Leite, V; Vrontakis, M E; Kasper, S; Friesen, H G 1993. Bromocriptine inhibits galanin gene expression in the rat pituitary gland. Molecular and cellular neurosciences, 4 5, 418-23

Kasper, S; Popescu, R A; Torsello, A; Vrontakis, M E; Ikejiani, C; Friesen, H G 1992. Tissue-specific regulation of vasoactive intestinal peptide messenger ribonucleic acid levels by estrogen in the rat. Endocrinology, 130 4, 1796-801

Fink, J S; Verhave, M; Kasper, S; Tsukada, T; Mandel, G; Goodman, R H 1988. The CGTCA sequence motif is essential for biological activity of the vasoactive intestinal peptide gene cAMP-regulated enhancer. Proceedings of the National Academy of Sciences of the United States of America, 85 18, 6662-6

Kasper, S; Friesen, H G 1986. Human pituitary tissue secretes a potent growth factor for chondrocyte proliferation. The Journal of clinical endocrinology and metabolism, 62 1, 70-6

Rowe, J M; Kasper, S; Shiu, R P; Friesen, H G 1986. Purification and characterization of a human mammary tumor-derived growth factor. Cancer research, 46 3, 1408-12

Kasper, S; Worsley, I G; Rowe, J M; Shiu, R P; Friesen, H G 1982. Chondrocyte growth factor from the human pituitary gland. The Journal of biological chemistry, 257 9, 5226-30

Giridhar P.; Kasper S.; Papautsky I.; Zhou J. 12-01-2013. Complete cell separation by modulating inertial force 2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013, , 1535-1538

Giridhar P.; Kasper S.; Nivedita N.; Papautsky I. 12-01-2011. Sorting human prostate epithelial (HPET) cells in an inertial microfluidic device 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, 2 , 1230-1232

Giridhar P.; Kasper S.; Papautsky I.; Zhou J. 12-01-2011. Extraction and enrichment of rare cells in a simple inertial microfluidic device 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, 3 , 1906-1908

Kasper S. 12-01-2008. Exploring the origins of the normal prostate and prostate cancer stem cell (Stem Cell Reviews DOI: 1 Stem Cell Reviews, 4 4, 329

Kasper S.; Papautsky I.; Zhou J. 11-01-2013. Enhanced size-dependent trapping of particles using microvortices Microfluidics and Nanofluidics, 15 5, 611-623

Bruchovsky N.; Kasper S.; Matusik R.; Rennie P.; Snoek R. 11-01-1996. Induction of cell-free, in vitro transcription by recombinant androgen receptor peptides Journal of Steroid Biochemistry and Molecular Biology, 59 3-4, 243-250

Kasper S. 10-01-2007. Editorial Comment Journal of Urology, 178 4, 1288

Andriani F.; Denner L.; Fang B.; Kagawa S.; Kasper S.; Li X.; Marcelli M.; Matusik R.; McPhaul M.; Nan B.; Weigel N.; Yu J. 09-05-2001. Use of the probasin promoter ARR<inf>2</inf>PB to express bax in androgen receptor-posit Journal of the National Cancer Institute, 93 17, 1314-1324

Bruchovsky N.; Gleave M.; Kasper S.; Matusik R.; Mawji N.; Rennie P.; Sato N.; Snoek R. 09-01-1998. Differential transactivation by the androgen receptor in prostate cancer cells Prostate, 36 4, 256-263

Giridhar P.; Kasper S.; Papautsky I.; Zhou J. 07-01-2014. Modulation of rotation-induced lift force for cell filtration in a low aspect ratio microchannel Biomicrofluidics, 8 4,

Borowsky A.; Dodd J.; Duckworth M.; Kasper S.; Matusik R.; Pettigrew N.; Prins G.; Sheppard P.; Yan Y. 06-01-1998. Erratum: Development, progression, and androgen-dependence of prostate tumors in probasin-large T an Laboratory Investigation, 78 6,

Giridhar P.; Kasper S.; Williams K. 04-19-2016. CD44 integrates signaling in stem cell microenvironments Role of Cancer Stem Cells in Cancer Biology and Therapy, , 129-150

Friesen H.; Kasper S.; Leite V.; Vrontakis M. 04-01-1993. Bromocriptine inhibits galanin gene expression in the rat pituitary gland Molecular and Cellular Neuroscience, 4 5, 418-423

Cunningham G.; Ittmann M.; Kasper S.; Li H.; Matusik R.; Shao T. 03-01-2006. Comparison of the growth-promoting effects of testosterone and 7-?-methyl-19-nor-testosterone (MENT) Prostate, 66 4, 369-376

Bai G.; Kasper S.; Krongrad A.; Matusik R.; Moshier J.; Rennie P. 03-01-1998. Androgen regulation of the human ornithine decarboxylase promoter in prostate cancer cells Journal of Andrology, 19 2, 127-135

Giridhar P.; Kasper S.; Papautsky I.; Zhou J. 01-01-2013. Modulation of aspect ratio for complete separation in an inertial microfluidic channel Lab on a Chip, 13 10, 1919-1929

Kasper S.; Lee C.; Masumori N.; Matusik R.; Shappell S.; Tsuchiya K.; Tsukamoto T.; Tu W. 01-01-2004. An allograft model of androgen independent prostatic neuroendocrine carcinoma derived from a large p Journal of Urology, 171 1, 439-442