Today is Saturday, Jul. 30, 2016

Department of

Environmental Health

Photo of  Mary Beth Genter, PhD

Mary Beth Genter, PhD


  • PhD: Duke University
  • BS: St. Lawrence University

Board Certifications & Licenses
  • Diplomate American Board of Toxicology, 1992, Diplomate, American Board of Toxicology
  • Fellow Academy of Toxicological Sciences, 2012, Fellow, ATS
Contact Information
  • Kettering 144 (lab); 158 (lab)
  • 160 Panzeca Way
  • Cincinnati, Ohio 45267-0056
  • Office (513)558-6266
  • Fax (513)558-4397
  • Email

Peer Reviewed Publications

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Genter, M. B.; 2014. Editor's Note. International journal of toxicology, 33 4, 267

Hsieh, H.; Amlal, H.; Genter, M.; 2014. Evaluation of the toxicity of zinc in the rat olfactory neuronal cell line, Odora. Human & experimental toxicology, ,

Dong, H.; Shertzer, H. G.; Genter, M. B.; Gonzalez, F. J.; Vasiliou, V.; Jefcoate, C.; Nebert, D. W.; 2013. Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins. Biochemical and biophysical research communications, 435 4, 727-32

Sasso, A. F.; Schlosser, P. M.; Kedderis, G. L.; Genter, M. B.; Snawder, J. E.; Li, Z.; Rieth, S.; Lipscomb, J. C.; 2013. Application of an updated physiologically based pharmacokinetic model for chloroform to evaluate CYP2E1-mediated renal toxicity in rats and mice. Toxicological sciences : an official journal of the Society of Toxicology, 131 2, 360-74

Shertzer, H. G.; Krishan, M.; Genter, M. B.; 2013. Dietary whey protein stimulates mitochondrial activity and decreases oxidative stress in mouse female brain. Neuroscience letters, 548 , 159-64

Barchowsky, A.; Buckley, L. A.; Carlson, G. P.; Fitsanakis, V. A.; Ford, S. M.; Genter, M. B.; Germolec, D. R.; Leavens, T. L.; Lehman-McKeeman, L. D.; Safe, S. H.; Sulentic, C. E. W.; Eidemiller, B. J.; 2012. The Toxicology Education Summit: building the future of toxicology through education. Toxicological sciences : an official journal of the Society of Toxicology, 127 2, 331-8

Curran, C. P.; Vorhees, C. V.; Williams, M. T.; Genter, M. B.; Miller, M. L.; Nebert, D. W.; 2011. In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes. Toxicological sciences : an official journal of the Society of Toxicology, 119 1, 189-208

Genter, M. B.; 2011. Editor's Note. International journal of toxicology, 30 4, 383

Shertzer, H. G.; Woods, S. E.; Krishan, M.; Genter, M. B.; Pearson, K. J.; 2011. Dietary whey protein lowers the risk for metabolic disease in mice fed a high-fat diet. The Journal of nutrition, 141 4, 582-7

Genter, M. B.; Krishan, M.; Augustine, L. M.; Cherrington, N. J.; 2010. Drug transporter expression and localization in rat nasal respiratory and olfactory mucosa and olfactory bulb. Drug metabolism and disposition: the biological fate of chemicals, 38 10, 1644-7

Hopf, N. B.; Kirkeleit, J.; Kramer, S. L.; Moen, B.; Succop, P.; Genter, M. B.; Carreón, T.; Mack, J.; Talaska, G.; 2010. Urinary 1-hydroxypyrene levels in offshore workers. International archives of occupational and environmental health, 83 1, 55-9

Genter, M. B.; Kendig, E. L.; Knutson, M. D.; 2009. Uptake of materials from the nasal cavity into the blood and brain: are we finally beginning to understand these processes at the molecular level? Annals of the New York Academy of Sciences, 1170 , 623-8

Genter, M. B.; Warner, B. M.; Medvedovic, M.; Sartor, M. A.; 2009. Comparison of rat olfactory mucosal responses to carcinogenic and non-carcinogenic chloracetanilides. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 47 6, 1051-7

Shertzer, H. G.; Schneider, S. N.; Kendig, E. L.; Clegg, D. J.; D'Alessio, D. A.; Johansson, E.; Genter, M. B.; 2009. Tetrahydroindenoindole inhibits the progression of diabetes in mice. Chemico-biological interactions, 177 1, 71-80

Kendig, E. L.; Schneider, S. N.; Clegg, D. J.; Genter, M. B.; Shertzer, H. G.; 2008. Over-the-counter analgesics normalize blood glucose and body composition in mice fed a high fat diet. Biochemical pharmacology, 76 2, 216-24

Shertzer, H. G.; Genter, M. B.; Talaska, G.; Curran, C. P.; Nebert, D. W.; Dalton, T. P.; 2007. 7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes. Carcinogenesis, 28 6, 1371-8

Genter, M. B.; Clay, C. D.; Dalton, T. P.; Dong, H.; Nebert, D. W.; Shertzer, H. G.; 2006. Comparison of mouse hepatic mitochondrial versus microsomal cytochromes P450 following TCDD treatment. Biochemical and biophysical research communications, 342 4, 1375-81

Genter, M. B.; Marlowe, J.; Kevin K. J.; Dragin, N.; Puga, A.; Dalton, T. P.; Nebert, D. W.; 2006. Naphthalene toxicity in mice and aryl hydrocarbon receptor-mediated CYPs. Biochemical and biophysical research communications, 348 1, 120-3

Shertzer, H. G.; Genter, M. B.; Shen, D.; Nebert, D. W.; Chen, Y.; Dalton, T. P.; 2006. TCDD decreases ATP levels and increases reactive oxygen production through changes in mitochondrial F(0)F(1)-ATP synthase and ubiquinone. Toxicology and applied pharmacology, 217 3, 363-74

Genter, M. B.; Warner, B. M.; Krell, H.; Bolon, B.; 2005. Reduction of alachlor-induced olfactory mucosal neoplasms by the matrix metalloproteinase inhibitor Ro 28-2653. Toxicologic pathology, 33 5, 593-9

Genter, M. B.; 2004. Update on olfactory mucosal metabolic enzymes: age-related changes and N-acetyltransferase activities. Journal of biochemical and molecular toxicology, 18 4, 239-44

Ling, G.; Gu, J.; Genter, M. B.; Zhuo, X.; Ding, X.; 2004. Regulation of cytochrome P450 gene expression in the olfactory mucosa. Chemico-biological interactions, 147 3, 247-58

Shertzer, H. G.; Clay, C. D.; Genter, M. B.; Chames, M. C.; Schneider, S. N.; Oakley, G. G.; Nebert, D. W.; Dalton, T. P.; 2004. Uncoupling-mediated generation of reactive oxygen by halogenated aromatic hydrocarbons in mouse liver microsomes. Free radical biology & medicine, 36 5, 618-31

Zhang, J.; Moseley, A.; Jegga, A. G.; Gupta, A.; Witte, D. P.; Sartor, M.; Medvedovic, M.; Williams, S. S.; Ley-Ebert, C.; Coolen, L. M.; Egnaczyk, G.; Genter, M. B.; Lehman, M.; Lingrel, J.; Maggio, J.; Parysek, L.; Walsh, R.; Xu, M.; Aronow, B. J.; 2004. Neural system-enriched gene expression: relationship to biological pathways and neurological diseases. Physiological genomics, 18 2, 167-83

Genter, M. B.; Apparaju, S.; hya; Desai, P. B.; 2002. Induction of olfactory mucosal and liver metabolism of lidocaine by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Journal of biochemical and molecular toxicology, 16 3, 128-34

Genter, M. B.; Burman, D. M.; Vijayakumar, S.; ian; Ebert, C. L.; Aronow, B. J.; 2002. Genomic analysis of alachlor-induced oncogenesis in rat olfactory mucosa. Physiological genomics, 12 1, 35-45

Senft, A. P.; Dalton, T. P.; Nebert, D. W.; Genter, M. B.; Puga, A.; Hutchinson, R. J.; Kerzee, J. K.; Uno, S.; Shertzer, H. G.; 2002. Mitochondrial reactive oxygen production is dependent on the aromatic hydrocarbon receptor. Free radical biology & medicine, 33 9, 1268-78

Uno, S.; Dalton, T. P.; Shertzer, H. G.; Genter, M. B.; Warshawsky, D.; Talaska, G.; Nebert, D. W.; 2001. Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyp1a1(-/-) knockout mice having increased hepatic BaP-DNA adduct levels. Biochemical and biophysical research communications, 289 5, 1049-56

Dalton, T. P.; Dieter, M. Z.; Matlib, R. S.; Childs, N. L.; Shertzer, H. G.; Genter, M. B.; Nebert, D. W.; 2000. Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery. Biochemical and biophysical research communications, 267 1, 184-9

Wetmore, B. A.; Mitchell, A. D.; Meyer, S. A.; Genter, M. B.; 1999. Evidence for site-specific bioactivation of alachlor in the olfactory mucosa of the Long-Evans rat. Toxicological sciences : an official journal of the Society of Toxicology, 49 2, 202-12

Genter, M. B.; Liang, H. C.; Gu, J.; Ding, X.; Negishi, M.; McKinnon, R. A.; Nebert, D. W.; 1998. Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse. Biochemical pharmacology, 55 11, 1819-26

Gu, J.; Zhang, Q. Y.; Genter, M. B.; Lipinskas, T. W.; Negishi, M.; Nebert, D. W.; Ding, X.; 1998. Purification and characterization of heterologously expressed mouse CYP2A5 and CYP2G1: role in metabolic activation of acetaminophen and 2,6-dichlorobenzonitrile in mouse olfactory mucosal microsomes. The Journal of pharmacology and experimental therapeutics, 285 3, 1287-95

Millhorn, D. E.; Conforti, L.; Beitner-Johnson, D.; Zhu, W.; Raymond, R.; Filisko, T.; Kobayashi, S.; Peng, M.; Genter, M. B.; 1996. Regulation of ionic conductances and gene expression by hypoxia in an oxygen sensitive cell line. Advances in experimental medicine and biology, 410 , 135-42

Genter, M. B.; Owens, D. M.; Deamer, N. J.; 1995. Distribution of microsomal epoxide hydrolase and glutathione S-transferase in the rat olfactory mucosa: relevance to distribution of lesions caused by systemically-administered olfactory toxicants. Chemical senses, 20 4, 385-92

Deamer, N. J.; O'Callaghan, J. P.; Genter, M. B.; 1994. Olfactory toxicity resulting from dermal application of 2,6-dichlorobenzonitrile (dichlobenil) in the C57Bl mouse. Neurotoxicology, 15 2, 287-93

Genter, M. B.; Deamer, N. J.; Cao, Y.; Levi, P. E.; 1994. Effects of P450 inhibition and induction on the olfactory toxicity of beta,beta'-iminodipropionitrile (IDPN) in the rat. Journal of biochemical toxicology, 9 1, 31-9

Genter, M. B.; Recio, L.; 1994. Absence of detectable P450 2E1 in bone marrow of B6C3F1 mice: relevance to butadiene-induced bone marrow toxicity. Fundamental and applied toxicology : official journal of the Society of Toxicology, 22 3, 469-73

Genter, M. B.; Szakál-Quin, G.; ; erson, C. W.; Anthony, D. C.; Graham, D. G.; 1987. Evidence that pyrrole formation is a pathogenetic step in gamma-diketone neuropathy. Toxicology and applied pharmacology, 87 2, 351-62

Rosenberg, C. K.; Genter, M. B.; Szakál-Quin, G.; Anthony, D. C.; Graham, D. G.; 1987. dl- versus meso-3,4-dimethyl-2,5-hexanedione: a morphometric study of the proximo-distal distribution of axonal swellings in the anterior root of the rat. Toxicology and applied pharmacology, 87 2, 363-73

Crofton, K. M.; Zhao, X.; Sayre, L. M.; Genter, M. B.; . Characterization of the effects of N-hydroxy-IDPN on the auditory, vestibular, and olfactory systems in rats. Neurotoxicology and teratology, 18 3, 297-303

Deshp; e, V. S.; Genter, M. B.; Jung, C.; Desai, P. B.; . Characterization of lidocaine metabolism by rat nasal microsomes: implications for nasal drug delivery. European journal of drug metabolism and pharmacokinetics, 24 2, 177-82

Genter, M. B.; . I am amazed at how time flies, and that we are now reading the fifth issue of International Journal of Toxicology for 2009! International journal of toxicology, 28 5, 339-40

Genter, M. B.; Deamer, N. J.; Blake, B. L.; Wesley, D. S.; Levi, P. E.; . Olfactory toxicity of methimazole: dose-response and structure-activity studies and characterization of flavin-containing monooxygenase activity in the Long-Evans rat olfactory mucosa. Toxicologic pathology, 23 4, 477-86

Genter, M. B.; Goss, K. H.; Groden, J.; . Strain-specific of alachlor on murine olfactory mucosal responses. Toxicologic pathology, 32 6, 719-25

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