Today is Tuesday, May. 31, 2016

Department of

Environmental Health

Mary Beth Genter, PhD


  • PhD: Duke University
  • BS: St. Lawrence University

Board Certifications & Licenses
  • Diplomate American Board of Toxicology, 1992, Diplomate, American Board of Toxicology
  • Fellow Academy of Toxicological Sciences, 2012, Fellow, ATS
Contact Information
  • Kettering 144 (lab); 158 (lab)
  • 160 Panzeca Way
  • Cincinnati, Ohio 45267-0056
  • Office (513)558-6266
  • Fax (513)558-4397
  • Email

Peer Reviewed Publications

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Genter, Mary Beth 2014. Editor's Note. International Journal of Toxicology, 33 4, 267

Hsieh, H., Amlal, H., & Genter, M. 2014. Evaluation of the toxicity of zinc in the rat olfactory neuronal cell line, Odora. Human & Experimental Toxicology, ,

Dong, H., Shertzer, H. G., Genter, M. B., Gonzalez, F. J., Vasiliou, V., Jefcoate, C., & Nebert, D. W. 2013. Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins. Biochemical and Biophysical Research Communications, 435 4, 727-32

Sasso, A. F., Schlosser, P. M., Kedderis, G. L., Genter, M. B., Snawder, J. E., Li, Z., Rieth, S., & Lipscomb, J. C. 2013. Application of an updated physiologically based pharmacokinetic model for chloroform to evaluate CYP2E1-mediated renal toxicity in rats and mice. Toxicological Sciences : An Official Journal of the Society of Toxicology, 131 2, 360-74

Shertzer, H. G., Krishan, M., & Genter, M. B. 2013. Dietary whey protein stimulates mitochondrial activity and decreases oxidative stress in mouse female brain. Neuroscience Letters, 548 , 159-64

Barchowsky, A., Buckley, L. A., Carlson, G. P., Fitsanakis, V. A., Ford, S. M., Genter, M. B., Germolec, D. R., Leavens, T. L., Lehman-McKeeman, L. D., Safe, S. H., Sulentic, C. E. W., & Eidemiller, B. J. 2012. The Toxicology Education Summit: building the future of toxicology through education. Toxicological Sciences : An Official Journal of the Society of Toxicology, 127 2, 331-8

Curran, C. P., Vorhees, C. V., Williams, M. T., Genter, M. B., Miller, M. L., & Nebert, D. W. 2011. In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes. Toxicological Sciences : An Official Journal of the Society of Toxicology, 119 1, 189-208

Genter, Mary Beth 2011. Editor's Note. International Journal of Toxicology, 30 4, 383

Shertzer, H. G., Woods, S. E., Krishan, M., Genter, M. B., & Pearson, K. J. 2011. Dietary whey protein lowers the risk for metabolic disease in mice fed a high-fat diet. The Journal of Nutrition, 141 4, 582-7

Genter, M. B., Krishan, M., Augustine, L. M., & Cherrington, N. J. 2010. Drug transporter expression and localization in rat nasal respiratory and olfactory mucosa and olfactory bulb. Drug Metabolism and Disposition: the Biological Fate of Chemicals, 38 10, 1644-7

Hopf, N. B., Kirkeleit, J., Kramer, S. L., Moen, B., Succop, P., Genter, M. B., Carreón, T., Mack, J., & Talaska, G. 2010. Urinary 1-hydroxypyrene levels in offshore workers. International Archives of Occupational and Environmental Health, 83 1, 55-9

Genter, M. B., Kendig, E. L., & Knutson, M. D. 2009. Uptake of materials from the nasal cavity into the blood and brain: are we finally beginning to understand these processes at the molecular level? Annals of the New York Academy of Sciences, 1170 , 623-8

Genter, M. B., Warner, B. M., Medvedovic, M., & Sartor, M. A. 2009. Comparison of rat olfactory mucosal responses to carcinogenic and non-carcinogenic chloracetanilides. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association, 47 6, 1051-7

Shertzer, H. G., Schneider, S. N., Kendig, E. L., Clegg, D. J., D'Alessio, D. A., Johansson, E., & Genter, M. B. 2009. Tetrahydroindenoindole inhibits the progression of diabetes in mice. Chemico-biological Interactions, 177 1, 71-80

Kendig, E. L., Schneider, S. N., Clegg, D. J., Genter, M. B., & Shertzer, H. G. 2008. Over-the-counter analgesics normalize blood glucose and body composition in mice fed a high fat diet. Biochemical Pharmacology, 76 2, 216-24

Shertzer, H. G., Genter, M. B., Talaska, G., Curran, C. P., Nebert, D. W., & Dalton, T. P. 2007. 7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes. Carcinogenesis, 28 6, 1371-8

Genter, M. B., Clay, C. D., Dalton, T. P., Dong, H., Nebert, D. W., & Shertzer, H. G. 2006. Comparison of mouse hepatic mitochondrial versus microsomal cytochromes P450 following TCDD treatment. Biochemical and Biophysical Research Communications, 342 4, 1375-81

Genter, M. B., Marlowe, J., Kevin Kerzee, J., Dragin, N., Puga, A., Dalton, T. P., & Nebert, D. W. 2006. Naphthalene toxicity in mice and aryl hydrocarbon receptor-mediated CYPs. Biochemical and Biophysical Research Communications, 348 1, 120-3

Shertzer, H. G., Genter, M. B., Shen, D., Nebert, D. W., Chen, Y., & Dalton, T. P. 2006. TCDD decreases ATP levels and increases reactive oxygen production through changes in mitochondrial F(0)F(1)-ATP synthase and ubiquinone. Toxicology and Applied Pharmacology, 217 3, 363-74

Genter, M. B., Warner, B. M., Krell, H., & Bolon, B. 2005. Reduction of alachlor-induced olfactory mucosal neoplasms by the matrix metalloproteinase inhibitor Ro 28-2653. Toxicologic Pathology, 33 5, 593-9

Genter, Mary Beth 2004. Update on olfactory mucosal metabolic enzymes: age-related changes and N-acetyltransferase activities. Journal of Biochemical and Molecular Toxicology, 18 4, 239-44

Ling, G., Gu, J., Genter, M. B., Zhuo, X., & Ding, X. 2004. Regulation of cytochrome P450 gene expression in the olfactory mucosa. Chemico-biological Interactions, 147 3, 247-58

Shertzer, H. G., Clay, C. D., Genter, M. B., Chames, M. C., Schneider, S. N., Oakley, G. G., Nebert, D. W., & Dalton, T. P. 2004. Uncoupling-mediated generation of reactive oxygen by halogenated aromatic hydrocarbons in mouse liver microsomes. Free Radical Biology & Medicine, 36 5, 618-31

Zhang, J., Moseley, A., Jegga, A. G., Gupta, A., Witte, D. P., Sartor, M., Medvedovic, M., Williams, S. S., Ley-Ebert, C., Coolen, L. M., Egnaczyk, G., Genter, M. B., Lehman, M., Lingrel, J., Maggio, J., Parysek, L., Walsh, R., Xu, M., & Aronow, B. J. 2004. Neural system-enriched gene expression: relationship to biological pathways and neurological diseases. Physiological Genomics, 18 2, 167-83

Genter, M. B., Apparaju, S., & Desai, P. B. 2002. Induction of olfactory mucosal and liver metabolism of lidocaine by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Journal of Biochemical and Molecular Toxicology, 16 3, 128-34

Genter, M. B., Burman, D. M., Vijayakumar, S., Ebert, C. L., & Aronow, B. J. 2002. Genomic analysis of alachlor-induced oncogenesis in rat olfactory mucosa. Physiological Genomics, 12 1, 35-45

Senft, A. P., Dalton, T. P., Nebert, D. W., Genter, M. B., Puga, A., Hutchinson, R. J., Kerzee, J. K., Uno, S., & Shertzer, H. G. 2002. Mitochondrial reactive oxygen production is dependent on the aromatic hydrocarbon receptor. Free Radical Biology & Medicine, 33 9, 1268-78

Uno, S., Dalton, T. P., Shertzer, H. G., Genter, M. B., Warshawsky, D., Talaska, G., & Nebert, D. W. 2001. Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyp1a1(-/-) knockout mice having increased hepatic BaP-DNA adduct levels. Biochemical and Biophysical Research Communications, 289 5, 1049-56

Dalton, T. P., Dieter, M. Z., Matlib, R. S., Childs, N. L., Shertzer, H. G., Genter, M. B., & Nebert, D. W. 2000. Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery. Biochemical and Biophysical Research Communications, 267 1, 184-9

Wetmore, B. A., Mitchell, A. D., Meyer, S. A., & Genter, M. B. 1999. Evidence for site-specific bioactivation of alachlor in the olfactory mucosa of the Long-Evans rat. Toxicological Sciences : An Official Journal of the Society of Toxicology, 49 2, 202-12

Genter, M. B., Liang, H. C., Gu, J., Ding, X., Negishi, M., McKinnon, R. A., & Nebert, D. W. 1998. Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse. Biochemical Pharmacology, 55 11, 1819-26

Gu, J., Zhang, Q. Y., Genter, M. B., Lipinskas, T. W., Negishi, M., Nebert, D. W., & Ding, X. 1998. Purification and characterization of heterologously expressed mouse CYP2A5 and CYP2G1: role in metabolic activation of acetaminophen and 2,6-dichlorobenzonitrile in mouse olfactory mucosal microsomes. The Journal of Pharmacology and Experimental Therapeutics, 285 3, 1287-95

Millhorn, D. E., Conforti, L., Beitner-Johnson, D., Zhu, W., Raymond, R., Filisko, T., Kobayashi, S., Peng, M., & Genter, M. B. 1996. Regulation of ionic conductances and gene expression by hypoxia in an oxygen sensitive cell line. Advances in Experimental Medicine and Biology, 410 , 135-42

Genter, M. B., Owens, D. M., & Deamer, N. J. 1995. Distribution of microsomal epoxide hydrolase and glutathione S-transferase in the rat olfactory mucosa: relevance to distribution of lesions caused by systemically-administered olfactory toxicants. Chemical Senses, 20 4, 385-92

Deamer, N. J., O'Callaghan, J. P., & Genter, M. B. 1994. Olfactory toxicity resulting from dermal application of 2,6-dichlorobenzonitrile (dichlobenil) in the C57Bl mouse. Neurotoxicology, 15 2, 287-93

Genter, M. B., Deamer, N. J., Cao, Y., & Levi, P. E. 1994. Effects of P450 inhibition and induction on the olfactory toxicity of beta,beta'-iminodipropionitrile (IDPN) in the rat. Journal of Biochemical Toxicology, 9 1, 31-9

Genter, M. B., & Recio, L. 1994. Absence of detectable P450 2E1 in bone marrow of B6C3F1 mice: relevance to butadiene-induced bone marrow toxicity. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology, 22 3, 469-73

Genter, M. B., Szakál-Quin, G., Anderson, C. W., Anthony, D. C., & Graham, D. G. 1987. Evidence that pyrrole formation is a pathogenetic step in gamma-diketone neuropathy. Toxicology and Applied Pharmacology, 87 2, 351-62

Rosenberg, C. K., Genter, M. B., Szakál-Quin, G., Anthony, D. C., & Graham, D. G. 1987. dl- versus meso-3,4-dimethyl-2,5-hexanedione: a morphometric study of the proximo-distal distribution of axonal swellings in the anterior root of the rat. Toxicology and Applied Pharmacology, 87 2, 363-73

Crofton, K. M., Zhao, X., Sayre, L. M., & Genter, M. B. . Characterization of the effects of N-hydroxy-IDPN on the auditory, vestibular, and olfactory systems in rats. Neurotoxicology and Teratology, 18 3, 297-303

Deshpande, V. S., Genter, M. B., Jung, C., & Desai, P. B. . Characterization of lidocaine metabolism by rat nasal microsomes: implications for nasal drug delivery. European Journal of Drug Metabolism and Pharmacokinetics, 24 2, 177-82

Genter, M. B., Deamer, N. J., Blake, B. L., Wesley, D. S., & Levi, P. E. . Olfactory toxicity of methimazole: dose-response and structure-activity studies and characterization of flavin-containing monooxygenase activity in the Long-Evans rat olfactory mucosa. Toxicologic Pathology, 23 4, 477-86

Genter, M. B., Goss, K. H., & Groden, J. . Strain-specific of alachlor on murine olfactory mucosal responses. Toxicologic Pathology, 32 6, 719-25

Genter, Mary Beth . I am amazed at how time flies, and that we are now reading the fifth issue of International Journal of Toxicology for 2009! International Journal of Toxicology, 28 5, 339-40

Genter-St.Clair . , ,