Today is Sunday, Apr. 23, 2017

Department of Environmental Health

Risk Science Center (RSC)

Dose Response Boot Camp

Dose Response BootCamp Logo

Current Courses

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May 8-12, 2017 in Cincinnati, Ohio! Register Here!

The course will be held at the University of Cincinnati, Kettering Laboratory in Cincinnati, OH. The course begins at 8:00am each day and ends approximately at 5:00 pm, with the exception of Friday, which normally ends at 2:00pm.

Course Fee

General (includes Federal Agencies): $2,100
(After March 1 - $2,300)

State/City/County/Tribal Employee: $1,600
(After March 1 - $1,800)

Course fee includes

  • Take home reference binder
  • Morning and afternoon breaks
  • Certificate of completion

Funding for Doctoral Students
The Society of Toxicology (SOT) offers awards up to $1000 to doctoral students for additional training that will enhance their career.  Check out the SOT STEP website for details.

Payment Policy

Registration is accepted on a first come, first serve basis. Full payment (in US funds) must be received in order to process your registration. Please call 513-558-1034 with questions.

Cancellation/Substitution Policy

Cancellations made on or before March 1, 2017 will be issued a refund less $150 administrative fee per person. Cancellations received between March 1, 2017 and March 31, 2017 will be issued a refund of 50%. No refunds will be issued after March 31, 2017. Substitutions are allowed with additional charge, but must be made by Friday, May 5, 2016. All requests for substitutions or cancellations must be made in writing via email to Ms. Patricia Nance at patricia.nance@uc.edu.

Accommodations

There are 2 hotels within walking distance to the course campus location: the Kingsgate Marriott Conference Center at the University of Cincinnati and the Hampton Inn & Suites Cincinnati/Uptown-University Area.

What is Dose-Response Assessment Boot Camp?  

It is an intensive, in-depth hands-on training in hazard characterization and dose-response assessment for human health risk assessments. This week-long course with emphasis on dose response assessment is based on our popular chemical risk assessment training sessions developed and presented to various audiences in the past decade. It is designed to provide systematic training in current assessment practices as well as in the latest methods in human health chemical risk assessments.  The course is for beginners through experienced toxicological risk   assessors who wish to learn advanced methods and enhance their understanding and skills in the basics.  The students will learn all aspects of hazard characterization and dose response assessment, and practice the skills learned in the classroom.  Upon completing the course, the participants will be able to derive and evaluate risk values and supporting documentation for non-cancer and cancer risk assessments and will receive a certificate documenting their successful completion of the course.  Five Certification Management (CM) points are available from the American Board of Industrial Hygienists (ABIH). It is also worth 4 Continuing Education Units (CEU). Click Here (PDF) for the course brochure.

This course is endorsed by the Society of Toxicology (SOT).
Society of Toxicology (SOT) Logo
And a recognized event by the Society for Risk Analysis (SRA).


General Course Information

Who should attend?

  • Risk assessors and toxicologists who conduct and write chemical assessments 
  • Risk assessors and toxicologists who review chemical assessments  
  • Risk managers or policymakers who use the results of chemical assessments and want to fully understand the processes involved in risk value development

 

Participant requirements

  • A basic understanding of toxicology
  • An interest in developing their skills in human health risk assessment

What you will learn

  1. Non-cancer and Cancer Risk Assessment Principles and Methods:  Learn how to  critically analyze effect data, understand toxicokinetic data and their use in understanding mode of action (MOA) and developing risk values. Learn how to incorporate uncertainty factors, utilize frameworks for considering MOA and human  relevance, and learn information synthesis approaches for hazard characterization and critical study identification, and calculation of risk values for non-cancer (e.g., reference doses or tolerable intakes) and cancer endpoints (e.g., cancer slope factors). Learn the latest methodologies used in dose-response assessment. 
  2. Dosimetric Adjustment Methods in Dose Response:  Learn how to develop interspecies oral dose adjustments for non-cancer and cancer assessment, cancer unit risk or slope factor conversion, inhalation exposure concentration unit conversion, and human equivalent concentration (HEC) calculation for particle and vapor exposure using various modeling approaches.  Applications of the results of physiologically-based pharmacokinetic (PBPK) modeling will also be introduced. 
  3. Benchmark Dose (BMD) Modeling and Application in Risk Assessment:   Learn how to do BMD modeling for non-cancer and cancer dose-response assessments and get hands-on experience using the latest EPA software.  Learn how to appropriately apply BMD modeling, choose models and parameters, select data and run models, and select the appropriate BMD as a point of departure in a human health risk assessment.  The course addresses all of the models in the EPA software, including dichotomous continuous, cancer, and nested models.
  4. Principles for the Application of Uncertainty Factors and Chemical Specific Adjustment Factor (CSAF) Methodology: Learn the concept of uncertainty factors and how they are used in non-cancer risk and safety assessment by USEPA and other organizations, and how data are used to   support values other than defaults.  Learn how to develop and use CSAFs according to the methods of the International Programme on Chemical Safety (IPCS), which includes the use of mechanistic and toxicokinetic data to replace default uncertainty factors for interspecies extrapolation and intraspecies variability in deriving risk values such as RfDs and Tolerable Concentrations (TCs).   
  5. Comprehensive Risk Assessment Practice:  Learn to develop, present and review a comprehensive non-cancer and cancer assessment for a complex sample chemical over the course of the entire week.

Boot Camp Software
Below are the links for the software you will need on your laptop for the Boot Camp Course. 

MPPD (Register and Download, the page ask you to "buy" the software but there is no charge for it, just fill out the information and they will email you a link to download software)  In order for this software to provide meaningful output, it is essential you have administrative read/write privileges for a directory in which MPPD writes a data file. This directory should be located here: C:/Documents and Settings/(your username)/AppData/Roaming/MPPD .

RDDR (.zip file, although this is EPA software, it is older software and not available on the EPA website) - this software may not run on your computer system without installing a virtual machine to run Windows XP, if you can not get the software to run, thats ok, we will show it in class.

U.S. EPA's Benchmark Dose Software (takes you to the USEPA's page for the software, you can register to receive updates or skip the registration)

Look at the Frequently Asked Questions for more details or for more information, please contact Ms. Patricia Nance at patricia.nance@uc.edu or 513-558-1054