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Dear Friends: Welcome to the CEG-hosted Web portal for NIEHS Environmental Health Sciences Core Center Resources. We are pleased to share with you this convenient tool for “one stop shopping” for state-of-the-art laboratory services, data analysis and other research services available from the CEG and other NIEHS-funded centers of excellence. If you have any comments or questions, please let us know. Thank you for visiting our site!
Please fill out this form to send us an update or addition to an EHS core center you manage.
Center for Environmental Health in Northern Manhattan
Grant number: P30 ES009089
Exposure Assessment Facility Core
Integrative Health Sciences Facility Core
Study Design and Data Analytics Facility Core
Click here to access the website of the NIEHS Center for Environmental Health in Northern Manhattan
HERCULES Exposome Research Center Health and Exposome Research Center; Understanding Lifetime Exposures
Website: https://emoryhercules.com
Facility Cores:
Untargeted Exposure Analysis (Dean Jones, PhD, Director): Untargeted Metabolomics is a standardized high-resolution protocol used to obtain a global view of metabolism and environmental exposures. The platform is suitable for use as a central reference for exposome research because of the expansive coverage (>20,000 chemical signals), including hundreds of know intermediary metabolites and a broad spectrum of environmental chemicals, food, pharmaceuticals, and microbiome-derived metabolites. High resolution metabolomics provides a central anchor for exposome research enabling generalized integration of multiple exposure metrics, measures of biologic response of an individual to exposures and metabolic changes consistent with disease pathophysiology to characterize environmental contributions to disease. Core request form: https://emoryhercules.com/facility-cores/metabolomics/.
Targeted Exposure Analysis (Dana Barr, PhD): The laboratory has 8 mass spectrometers (GC-MS/MS and GC-MS; 3 HPLC-MS/MS and HPLC-MS, FTMS and ICP-MS) that enable the analysis of the entire gamut of environmental toxicants, hormones, and other organic and inorganic compounds ranging from metals to proteins. With state-of-the-art analytical technologies and complementary scientific experience, assays can be developed to target specific research needs. Core request form: https://emoryhercules.com/facility-cores/targeted-analysis/ .
Click here to access the HERCULES website
Grant number: P30 ES030285-03
Website: https://gc-cpeh.org/
GC-CPEH Facility Cores (PIPELINE FC and IHSFC) provide GC-CPEH investigators priority access to world-class expertise and cutting-edge technologies supporting precision environmental health research. The resources include in-house services, consultation with our navigators, or placing "3rd party fee-for-service" orders that could not be processed in-house. It relies on core facilities labs and resources at Baylor College of Medicine (BCM), Houston, TX; University of Texas Health Science Center (UTHSC), Houston, TX; and University of Texas Medical Branch (UTMB), Galveston, TX. For each of the PIPELINE /IHSFC Resources listed below, a Navigator with subject matter expertise and a record of both publications and funded grants is available to assist Center investigators with optimizing Resource utilization. If you have any questions about the GC-CPEH Facility Cores, contact us by email at gc-cpeh@bcm.edu.
Integrated Health Sciences Facility Core (IHSFC): The IHSFC, led by Elaine Symanski, PhD and Philip Lupo, PhD, provides access to expertise and capabilities to foster translational studies (basic sciences into clinical and population studies) that can ultimately be disseminated to the community. IHSFC resources available to GC-CPEH investigators are: Population and Clinical Science (Navigators: Michael Scheurer, PhD, George Delclos, PhD, Winnie Hamilton, PhD, Lance Hallberg, PhD, and Philip Lupo, PhD).Services offered include consultation, designing and conducting population and clinic-based investigations of the impact of environmental exposures on human health:
Harvard NIEHS Center for Environmental Health
Core Resources:
Website: Harvard NIEHS Center for Environmental Health
Center on Health and Environment Across the LifeSpan (HEALS) formerly the Transdisciplinary Center on Health Effects of Early Environmental Exposures Core Resources:
Click here to access the website of the Center on Health Across the LifeSpan
Center for Community Health: Addressing Regional Maryland Environmental Determinants of Disease (CHARMED)
Exposure Characterization and Monitoring Core Resources
Click here to read more about the Johns Hopkins University P30 Center (CHARMED)
Center for Environmental Health Science
Grant number: P30 ES00210
Animal Models Facilities Core Contact: Prof. James Fox
The Animal Models Facilities Core, directed by Professor James Fox of the Division of Comparative Medicine and the Department of Biological Engineering, provides Center members with the latest technology for the application of animal models to environmental health research. Center members are provided with an extensive array of services related to animal models and pathology. The objective of the Animal Models Facilities Core is to provide Center members with state-of-the-art pathology and imaging support, transgenic resources and a centrally-managed AAALAC-approved animal holding and surgical facility. The Core is staffed with experienced personnel and is equipped with essential equipment to generate genetically engineered mice, cryopreserve sperm and embryos, rederive imported mice by embryo derivation, provide colony management, prepare and interpret tissue samples by histological and image analysis. Bioimaging and Chemical Analysis Facilities Core Contact: Dr. Bogdan Fedeles and Dr. Michael DeMott This Facilities Core is overseen by Drs. Bogdan Fedeles and Michael DeMott. The Bioimaging and Chemical Analysis Facilities Core is a central resource in analytical chemistry, separation science, metabolomics, and proteomics for Center members, and provides research participants with analytical expertise, training, and access to state-of-the-art instrumentation. This Facilities Core is home to a world-class chromatography and mass spectrometry facility, and provides CEHS members with state-of-the-art molecular separation, identification, and quantification capabilities, along with consultation for training, experimental design, and data interpretation. Genomics and Informatics Facilities Core Contact: Dr. Stuart Levine The Genomics and Informatics Facilities Core, led by Dr. Stuart Levine, provides CEHS researchers with access to state-of-the art tools, services and expertise in the areas of genomics, systems biology, bioinformatics, and BioIT. These tools provide researchers a broad spectrum of technologies to understand cell state and how environmental stresses result in perturbations of the cellular systems and human health. The core services are available either through walkup or assisted services and training is available in all areas. Integrative Health Sciences Facilities Core Contact: Prof. Michael Yaffe and Prof. James Fox The CEHS research portfolio extends from basic studies of the physics and chemistry of our environment to clinical studies of how exposure impacts human health and, then ultimately to policy recommendations that protect and improve public health and welfare. The Integrative Health Sciences Facilities Core (IHSFC) enhances the impact of laboratory research by lowering the barriers to clinical translation of basic studies into new clinical practice. In doing so, the IHSFC amplifies the impact of CEHS by helping to deliver of our science and engineering advances to help people. The strength of the IHSFC lays in its leadership, which is comprised of basic researchers, leaders in technology development, animal researchers, clinicians, and an epidemiologist. While a great strength of the IHSFC is its clinical connection and support, it is important to note that the IHSFC facilitates translations at all levels from the most basic research, to animal and human studies and ultimately to work that impacts policy.
Center for Human Health and the Environment
Website: http://chhe.research.ncsu.edu/
Pacific Northwest Center for Translational Environmental Health Research
Grant number: P30 ES030287
Website: https://ehsc.oregonstate.edu/
Zebrafish Biomedical Research Core: The Zebrafish Biomedical Models Facility Core is unique worldwide as a facility equipped to conduct biomedical research using zebrafish as aquatic research models. It primarily consists of a self-contained fish hatchery and high throughput screening facility for toxicity and behavioral studies
ZBR Capabilities:
Chemical Exposure Core: The CXC is an state of the art facility specializing in Environmental Sampling. The core offers passive sampling devices (PSDs) including low density polyethylene (LDPE) for stationary monitors as well as silicone wristbands/dog-tags for personal exposure monitoring. The core also offers analytical services for sample PSD extracts, enabling EHS CC members to measure concentrations of environmental toxins in personal exposures, air, water, sediments, and soils.
CXC Capabilities:
Chemical Methods
Sampling technology
Training Videos and FAQs
Community Engagement Core: The Community Engagement Core facilitates collaborations between stakeholders and researchers in the Pacific Northwest. The CEC collaborates with the Oregon Clinical & Translational Research Institute (OCTRI) Research Liaisons and the Oregon State University Extension Service to identify environmental health concerns throughout the Pacific Northwest. The Core emphasizes stakeholder-engaged research to ensure research is relevant, with an emphasis on translating research results to improve environmental public health. The core helps stakeholders and researchers initiate engaged research, translate research results and return data to study participants.
Integrated Health Sciences Facility Core: The IHSFC provides connections and resources to establish team science-based collaboration to transform the way we perform environmental health research across an enhanced definition of NIH-defined T0-T4 translation.
IHSFC Capabilities:
Center for Environmental Exposures and Disease (CEED)
Grant number: P30 ES005022
Website: https://ceed.rutgers.edu/
Recently, Professor Philip Demokritou, formerly a faculty member at the T.H. Chan School of Public Health at Harvard University and Director of the NIEHS-funded Harvard Center for Nanotechnology and Nanotoxicology (HCNN), joined our team at Rutgers University as the Henry Rutgers Chair and Professor of Nanoscience and Environmental Bioengineering. Dr. Demoknitous is establishing at Rutgers a Nano-biosciences and Advanced Materials Research Center (NAMC). The NAMC will integrate material & exposure science and nanotoxicology risk assessment to pave the way towards safer development of nano and other advanced materials. The Center will bring together ALL stakeholders -- industry, academia, policy makers and the general public -- to work together towards addressing EHS challenges from emerging materials.
Research priorities of the NAMC center include interactions of advanced materials with biological and environmental systems and their potential EHS implications; development of novel methods for the physico-chemical and biological characterization of materials across their life cycle using in-vitro and in-vivo systems; development of safer by design advanced materials to minimize EHS Risks; development of advanced material approaches for emerging 21st Century public health challenges such as food safety and quality, air disinfection, agri-chemical delivery and biomedical applications. The NAMC Center will be part of the NIH/NIEHS National Health Implications Research (NHIR) Consortium, which was formed by NIEHS to assess potential adverse health effects of emerging engineered nanomaterials (ENMs).
A wide range of shared equipment through Core Facilities is available through the NIEHS Center for Environmental Exposures and Disease. These facility cores provide access to state-of the-art equipment mass spectrometry, including ICMPS with ion speciation, multi-laser cell sorting, flow cytometry, image analysis, confocal microscopy, bioinformatics, biostatistics, computational biology, as well as molecular pathology and histology. All of these cores are available to the project at reduced cost as a service and/or a in a collaborative mode, both of which include consultation and training as required.
Nano/Advanced Materials capabilities through the Rutgers NAMC Center (PI and Director, P. Demokritou):
A wide range of state of the art equipment and instrumentation for the characterization of engineered and environmental nanoparticles in biological and environmental media are available to investigators and students. In addition, NAMC Center has in place state of the art platforms to synthesize a wide range oh engineered and environmental nanoparticles including systems to synthesize metal and metal oxides, cutting edge 2D/3D ENMs such as CNTs, graphene, h2BN, nanocellulose, advanced nanocomposites, etc. NAMC also has in place exposure generation platforms for environmental nanoparticles such as thermal incineration platforms to generate combustion related nanoparticles from wild fires and secondary nanoplastics, electronic cigarette exposure systems, etc. NAMC also houses the NIEHS/NHIR Reference ENM repository, the most extensive material library currently available at the national and international level for nanotoxicology research which includes more than 50 materials which are currently used in nanotoxicology and nanobiology research across the NIEHS/NHIR consortium.
Multi-laser Cell Sorting and Animal imaging
DNA and RNA Sequencing
High resolution Mass Spectrometry/ ICPMS with ion Speciation/ Metabolomics
Analysis of DNA Methylation
Analysis of Circadian Rhythm
Controlled Human Exposure Facility
Bioinformatics and Computational Biology/ Modeling
Chicago Center for Health and Environment
Grant number: P30 ES0277792
Website: ChicAgo Center for Health and Environment (CACHET)
Integrated Health Sciences Facility Core (IHSFC) ensures that CACHET members at both institutions have stewardship, support, and access to key infrastructure for their translational research projects in Chicago and global locations. In addition to providing tailored, specialized statistical methods and analytical support for complex environmental scenarios, IHSFC interfaces with other facility cores to arrange specific services for users’ translational studies.
Study Design, Population Cohorts, and Biobank provides CACHET members with: 1) infrastructure and services to design and implement translational EHS research; 2) access to trained research personnel with experience in recruiting diverse study participants; 3) infrastructure and expertise for planning, collection, processing, and storage of specimens; 4) access to existing cohorts; and 5) support to enhance translational research partnerships.
Human Population Exposures provides expert advice on environmental exposure assessment approaches. Services include: 1) consultation on methods and existing data sources; 2) device deployment and data collection; 3) data management; and 4) advanced data sciences and computational services.
Biostatistics and Modeling provides statistical and quantitative modeling support to CACHET investigators. These leaders develop statistical methodologies to promote new EHS research directions, including complex exposure modeling with highly correlated or mixed exposures, geo-spatial analyses, and gene-environment analyses, enabling the IHSFC to provide tailored statistical methods and analytical support for complex EHS research.
Community Engagement Core (CEC) engages Chicago communities and stakeholders in an iterative multi-directional process to identify and address environmental hazards of concern. The CEC’s long-term goal is to build transdisciplinary research teams that directly address emerging community concerns, translate findings into action, and disseminate research results to the community, healthcare providers, regulators, and policymakers. With support from IHSFC, CACHET members design, implement, and analyze studies that include external collaborations with other EHS Centers or institutions when outside expertise is required. The CEC disseminates findings using a community-first communication model.
Environmental Biomarkers Core: CACHET has reorganized its former Biomarkers Core into an Environmental Biomarkers Core (EBC) consisting of two Sub-Cores: 1) a mass-spec-based Environmental Exposures Assessments Sub-Core that is P30-specific in its services and resources available to members, and 2) a Biomarkers of Exposure Effects Sub-Core that streamlines member services by leveraging existing institutional resources at UIC and UofC. Both components provide methodologic training, priority access, and considerably subsidized services to CACHET members. Together, the EBC will: 1) provide CACHET members with access to analytical support that enables determination of exposures to environmental toxins in biological and environmental samples as well as biomarkers indicating the physiological effects of and susceptibility to such exposures; 2) develop new assays and acquire new instrumentation to support evolving research within CACHET; and 3) offer expertise in design and interpretation of assay measurements conducted for CACHET members.
A primary role of the EBC is to provide access to advanced analytical measurement. Additionally, the EBC works to develop new assays and analytical procedures to support new research efforts within CACHET. These efforts may include developing and validating new methods for detection and quantitative analysis of specific EDCs, pesticides, and emerging chemicals in environmental or human/animal samples, or measurement of emerging biomarkers of exposure (e.g., targeted/untargeted metabolites) and effects (e.g., short-chain fatty acids, bile acids) in biosamples. EBC also facilitates access to genomics, transcriptomics, microbiome/metabolomics, and other -omics services from existing institutional FCs. Different EBC services are available to all CACHET members on the two campuses; MS at UIC and microbiome, metabolome, and genomics/epigenomics at UofC.
Click here to read more at the ChicAgo Center for Health and Environmental (CACHET) Website
Southwest Environmental Health Sciences Center
Genomics Facilities Core
Cellular Imaging Core
NOTE: Unique resources include each of our arsenic (As) species and three recently installed light microscopes. Texas A&M’s Center for Translational Environmental Health Research is the only other center that might have these state-of-the-art scopes. These are fee-for-service microscopes, so while external use is welcome, users would be required to pay for time on the scopes. Technical expertise is on site for all of the scopes at no additional charge.
Integrative Health Sciences Facilities Core
content pending
Website: Southwest Environmental Health Sciences Center
UC-Davis Environmental Health Sciences Center
Website: https://environmentalhealth.ucdavis.edu/
Community Engagement Core (CEC)
The CEC acts as a bridge between communities and academia by brokering partnerships that solve environmental health problems at the local level. It does this through its pilot projects or other initiatives and Community Stakeholder Advisory Committee (CSTAC), which is made up of government and local leaders in environmental health and justice organizations.
Environmental Exposure Core (EEC): The EEC provides researchers with expertise in study design, exposure assessment and interpretation of data. EEC member laboratories include:
Integrative Health Sciences Facility Core (IHSFC): The IHSFC provides researchers with access to experts and resources across a variety of colleges, schools and centers.
Visit us at https://environmentalhealth.ucdavis.edu/ or on Twitter, Facebook, Instagram or YouTube.
UCSF Environmental Research and Translation for Health Center (EaRTH Center)
Grant number: P30 ES030284
Website: https://earth.ucsf.edu/
Integrated Health Sciences Facility Core: The EaRTH Center IHSFC provides investigators access to environmental health, epidemiology, biostatistics/informatics, and research translation resources to substantially advance their capacity to study adverse health effects of environmental exposures and broadly communicate their research findings. Services include:
Bioassay Facility Core:
Center for Environmental Genetics
Integrative Technologies Services (ITS) Core
Bioinformatics Core
Environmental Health Sciences Research Center
Website: University of Iowa: Environmental Health Sciences Research Center
Center for Appalachian Research in Environmental Sciences (UK CARES)
Analytical Core: Primarily provides services using GC and LC coupled mass spectrometry with multistage and high resolution instruments for quantitation of small molecules of broad relevance to environmental disease researchers. The laboratory contains two Agilent GC MS systems with quadrupole and triple quadrupole mass analyzers as well as electron capture and flame ionization detectors. It contains three ABSciex triple quadrupole linear ion tram mass spectrometer systems with Shimadzu HPLC and UPLC systems as well as an ABSciex quadrupole time of flight mass spectrometer system with HPLC and microflow chromatography systems and a Thermo Q-Exactive quadripole orbitrap mass spectrometer with a dionex UPLC system. The laboratory also contains extensive equipment for sample preparation including automated systems for solid phase and accelerated solvent extraction as well as solvent evaporation including several Caliper Turbovap evaporators and a large volume genevac solvent evaporator. The laboratory can conduct measurements of many different classes of pollutants in biological or environmental matrices including serum and blood plasma, tissues, water and soil. Areas of emphasis include polychlorinated biphenyls, dioxins, polychlorinated benzodifurans, per- and polyfluoroalkyl substances, and bisphenols. Published methods for other established and emerging persistent organic pollutants and biomarkers of exposure to these pollutants can be set up and validated for use in preclinical or clinical studies as needed.
UK CARES is led by Director Xianglin Shi, PhD; Professor and William A. Marquard Chair in Cancer Research, Department of Toxicology and Cancer Biology
Website: https://cred.med.uky.edu/niehs-p30-center
Center for Integrative Environmental Health Sciences
Grant number: P30 ES030283
Integrated Health Science Facility Core (IHSFC): The multi-disciplinary Integrated Health Sciences Facility Core (IHSFC) provides infrastructure facilitating translational human subjects EHS research for the CIEHS, UofL, and the community. The ultimate goal is to improve public health and clinical practice in affected communities. The IHSFC supports patient-oriented clinical research (e.g., the early detection, prevention, and therapy of environmentally related disorders); group and population-based research; as well as community engaged/led research. The IHSFC is comprised of two interacting subunits: The Research Administration and Planning Subunit (RAPS) lead by Drs. Luz Huntington-Moskos and Juw Won Park and the Research Implementation Subunit (RIS) lead by Drs. Craig McClain and Janice Sullivan. Matt Cave, M.D., a physician-scientist and recent NIEHS RIVER awardee, directs the IHSFC. In addition, Dr. Charlie Zhang is available under the IHSFC for assistance with Geospatial studies and Dr. Kira Taylor is available for assistance with Epidemiology studies. The IHSFC interacts with other CIEHS Cores to provide access to state-of-the-art instrumentation and technologies; increase multidisciplinary collaboration; and enhance partnerships with community-based organizations. https://louisville.edu/ciehs/cores/ihsfc
Omics & Exposure Facility Core (OEFC): The Omics & Exposure Facility Core (OEFC) organizational design is to create a central resource for CIEHS members, allowing them to understand, access and effectively use environmental ‘omics and measurement resources currently available at the UofL. The OEFC enables and supports integrated services for Genomics and Transcriptomics, Proteomics, Metabolomics, Metallomics, Environmental Exposures and Assessments, and Microbiome studies. The OEFC will work closely with other CIEHS facility cores to plan research project support, support of CIEHS investigator and pilot project grant applications as well as pursue support of broad dissemination of OEFC capabilities and research successes to the affected or interested populations with greater Louisville community and beyond to national and international stages. Michael L. Merchant, PhD OEFC director and Proteomics shared resource director. https://louisville.edu/ciehs/cores/oefc
Biostatistics and Informatics Facility Core (BIFC): The goal of the BIFC is to provide state-of-the-art statistical and bioinformatics support in design, analysis and dissemination of findings of a range of basic science, transcriptomic, translational, clinical, population health and environmental epidemiology studies. Provide support for the integration of multi-omics data from both animal and human studies, facilitate integration of exposure data with lifestyle factors to identify effect modifiers and mediators of the health effects of environmental exposures, and educate center investigators, staff and trainees in new methods related to statistics/biostatistics approaches applicable to their research activities. Juw Won Park, Ph.D. and Maiying Kong, Ph.D. are the BIFC Co-Directors.
Services and technologies: Services provided includes (a) Generate hypotheses based on background data and sample size calculation related to miRNA, RNA-Seq, Proteomics, Metabolomics and Microbiota data for animal studies involving balanced ANOVA Model; (b) Analysis of animal studies with simple approach (two-group comparison) and efficient ANOVA models, and design and analyses of clinical studies involving retrospective and prospective clinical studies- cross sectional, cross-over and longitudinal; (c) Analyses with FDR correction of miRNA, RNA-Seq, Transcriptomics, Proteomics, Metabolomics and Microbiota data; (d) Statistical and bioinformatics consideration section for protocols and grants, and provide data, safety and monitoring in clinical trials; (e) Develop and validate R and SAS programs and perform statistical analysis and prepare statistical reports, and develop efficient and robust biostatistics and bioinformatics methods. Analysis includes methods such as survival analysis, longitudinal analysis, missing data analysis, high-dimensional data analysis including GWAS, Microbiome data, high-throughput sequencing data, Proteomics data, Microarray data, Pathway and network analyses. Areas of special interest include repeated measures models, measurement error, spatio-temporal methods, computational biology, statistical genetics, clinical informatics and Bayesian methods. https://louisville.edu/ciehs/cores/bifc
Click here to visit the website of the Center for Integrative Environmental Health Sciences (CIEHS)
Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)
Grant number: P30 ES017885 Exposure Assessment Core The Exposure Assessment Core supports the design, implementation and analysis of exposure assessments, and provides assistance to ensure that exposure assessments and analytical data generated are sound, quality assured and reflect state-of-the-art knowledge and expertise. The Core provides assistance with sample collection, storage, preservation, processing, and analysis for environmental and biological samples, and referral services to supporting laboratories for analytes not measured by the Core itself. The Core also provides consultations regarding exposure data, including study design, data cleaning, data interpretation, error calculations, and the use of environmental models and databases, such as those pertaining to air quality, water quality, and soil quality. Integrated Health Sciences Core Consultation on community-based environmental health problems: The Integrated Health Sciences Core (IHSC) facilitates interaction to strengthen the connection between research and community and practice. The IHSC provides translational consultation to assist Center investigators in identifying ways that our associated biorepositories and Cores can be used in preparing pilot projects or full grant proposals. Biostatistical consultation and collaboration are provided to help ensure that Center studies are well designed, and that appropriate statistical methodology is used in their analysis. This service includes guidance with general study design, feasibility, specimen collection fundamentals, case report form development and human subjects regulations, as well as re-directing investigators to appropriate collaborators for more in-depth and specialized collaboration or consultation (e.g., detailed study design or assay methods). Biorepository services: A service of the Integrated Health Sciences Core; identifies physical facilities and best practices for specimen collection, storage, labeling, and retrieval, and referrals to potential collaborators with existing biorepositories. Pan Omics and Data Science Core The Pan-Omics and Data Science Core (PODS) provides comprehensive and innovative support for study design, sample preparation, analysis, interpretation, and integration of a broad range of omics studies. PODS also delivers cutting edge analytic methods to integrate and apply high-dimensional data to translational studies. The Core offers services to M-LEEaD investigators and members of their research teams, and to M-LEEaD pilot grant recipients. Researchers will have access to full services for epigenomics experiments; individual labs may submit cells for DNA/RNA extraction or ChIP-DNA for ChIP-Seq. The core will perform sample library preparation for the main DNA methylation platforms and sequencing applications, RNA-seq, or ChIP-seq. Center researchers can directly request access to technologies such as whole-genome sequencing, small RNA sequencing, microarrays, etc. ChIP-seq, microarrays, microRNA expression, HumanMethylation450 BeadChip, reduced representation (RRBS) or whole-genome (WGBS) bisulfite sequencing, MeDIP-seq, MethylCap-seq, hmeDIP-seq, and Enrichment testing (pathway analysis).
UNC Center for Environmental Health and Susceptibility
INTEGRATED HEALTH SCIENCES FACILITY CORE (IHSFC): The Integrated Health Sciences Facility Core (IHSFC) facilitates translation of research from laboratory models to human studies.
MOLECULAR ANALYSIS AND STATISTICAL SUPPORT (MASS) CORE: The Molecular Analysis and Statistical Support (MASS) Facility Core is a concierge and advanced scientific support core that connects campus-wide networks to offer expertise, technical support, methods development, oversight, and tracking. MASS integrates university services and fills expertise and methods gaps for CEHS members. MASS functions as a research accelerator by providing highly qualified expertise and staffing, together with connections to relevant on-campus services. The MASS reduces time to data collection and interpretation by at least six months.
The two thematic foci of this support unit are Molecular Analysis and Statistical Support.
Molecular Analysis. The molecular analysis needs of CEHS investigators evolve over time and the MASS provides scientific support, networks, negotiated pricing, and priority access for members to utilize a range of University-wide subcores and to support novel methods development to meet members’ needs. The MASS develops new technologies and capabilities within existing cores and negotiates relationships with partner subcores. Three major domains and core-relationships have been sustained over time and are strategically integrated in Center: Biomarker Mass Spectrometry (BMS), Pathology Services Core (PSC), and Office of Genomics Research (OGR).
Statistical Support. With support from the UNC Department of Biostatistics, one of the top four departments of biostatistics nationwide, the MASS delivers state-of-the-art support in areas ranging from personalized medicine to clinical trials to epigenetics and covering topics such as study design, power calculations, dose-response analysis, longitudinal data analysis, survival analysis, causal inference, semi-parametric methods, statistical genetics, gene-environment interaction, and bioinformatics. Key features include: Integration between data design and acquisition, Highly-qualified personnel, rapidly mobilized for standardized work flows, Cost-effectiveness, and Novel methods development.
Click here to explore the website of the Center for Environmental Health Susceptibility.
Center of Excellence in Environmental Toxicology
Note: While these unique resources are sharable, sharable does not mean without cost when "fee" structures exist at our institution.
Website: Center of Excellence in Environmental Toxicology
University of Rochester Environmental Health Sciences Center
Grant number: P30 ES00127
Website: https://www.urmc.rochester.edu/environmental-health-sciences.aspx
Click here to explore the Rochester Environmental Health Sciences Center website
Southern California Environmental Health Sciences Center
Website: https://pphs.usc.edu/divisions/biostatistics/
Interdisciplinary Center for Exposures, Diseases, Genomics and Environment (EDGE)
Grant number: P30 ES007033
The Core is comprised of three complementary components: 1) The Genomics Component provides genomics, epigenomics, transcriptomics, proteomics, and metabolomics resources. 2) The Bioinformatics & Biostatistics Component provides data analysis expertise for all types of OMICs data and beyond. 3) The Microphysiological Systems Component (MPSC) offers access to sophisticated 3D in vitro model systems that mimic the complex cellular architecture of organs. The MPSC offers a unique experimental system for validating discoveries revealed by OMICs analyses. A more detailed description of the services the three components offer is provided below.
Genomics Component
Supporting preparation of manuscripts and grant proposals
Bioinformatics & Biostatistics Component
Experimental design consultation for OMICs and non-OMICs experiments
Comprehensive statistical and bioinformatics analysis of:
Mining of publicly available OMICs data
Multi-omics data integration
Consultation for statistical analysis of non-OMICs data
Supporting preparation of manuscripts, grant proposals
Integrated Health Sciences Facility Core (IHSFC): Clinical & Translational Services
The Exposure assessment, Biomarkers and Environmental Sensing Facility Core (EABES) of the EDGE Center provides the following capabilities and services to support research and training in the Environmental Health Sciences at the University of Washington:
Website: http://deohs.washington.edu/edge/
Center for Urban Responses to Environmental Stressors (CURES)
Grant number: P30 ES020957
Website: https://cures.wayne.edu/
Exposure Signatures Facility Core The ESFC measures environmental toxicants and the biological consequences of toxicant exposure in biological samples and in complex environmental matrices. The goal is to integrate measurements of the amount of toxicant exposure with measurements of gene expression, protein abundance or signaling molecule status that indicate the impact of exposure in the individual. The ESFC provides analytical services for Genomics, Proteomics, Toxicants, Metabolites, Lipids, Cytokines, Metals and Flow Cytometry. Co-leaders: Douglas Ruden, PhD, Institute of Environmental Health Sciences, Director of Epigenomics, C.S. Mott Center for Human Growth and Development; Paul Stemmer, PhD, Institute of Environmental Health Sciences, Director of Proteomics Core Facility
Integrative Health Sciences Facility Core The IHSFC facilitates translational research and its impacts by bridging connections between our researchers and our community partners and public health arenas. Through multi-directional communication and team-building, the IHSFC translates community environmental health concerns to and from the CURES research infrastructure. We provide enhanced partnerships and access to resources, including biostatistical and study design support, geospatial analysis and data visualization services, team science-based team building, regulatory and ethical support, and the latest tissues and techniques to enhance our researchers’ ability to characterize environmental stressors impacting Detroit residents. Co-leaders: Graham Parker, PhD, Department of Pediatrics; Samiran Ghosh, PhD, Dept. of Family Medicine and Public Health Sciences and Dept. of Molecular Medicine and Genetics; J. Richard Pilsner, MPH, PhD, Dept. of Obstetrics and Gynecology, Director of Molecular Genetics and Infertility, Institute of Environmental Health Sciences; IHSFC Coordinator: Jessica Worley, MPH, Institute of Environmental Health Sciences
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