The mission of the Center for Environmental Genetics (CEG) is to understand how genetic/epigenetic variability influences disease risk and health outcomes in response to chronic and/or acute exposure(s) to environmental agents, in the presence of developmental or lifestyle modifiers, with the ultimate aim of preventing human disease and disability and improving individual and population health. CEG investigators, trainees and collaborators are currently focused on studying gene-environment interactions in four disease areas, reflecting population health concerns most salient in our region:
- Endocrine disruption and cancer
- Immune and allergic diseases
- Cardiovascular and lipid disorders
- Neurological and behavioral disorders
We at the CEG pursue our mission while paying particular attention to the early origins of disease, windows of susceptibility, the interplay between genetics and epigenetics, the influence of lifestyle modifiers on epigenetic reprogramming, and the “data void” related to continuous lifelong editing of developmental programming and the potential for trans-generational effects.
The CEG is led by Shuk-Mei Ho, PhD, Jacob G. Schmidlapp Professor & Chair of the Department of Environmental Health and Associate Dean for Basic Research in the University of Cincinnati College of Medicine and Director of the Cincinnati Cancer Center. In 2015 Dr. Ho received the University's prestigious Rieveschl Award for Distinguished Scientific Research, based on the respect and admiration of her peers. She is a nationally and internationally recognized leader in endocrine disruptor and cancer research and has been profiled in the Journal of Endocrinology and Cancer, 2014 Aug;21(4):19-24. PMID 24928923.
Some of the many faces of the CEG. The Center is comprised of more than 50 geneticists, epidemiologists, toxicologists, immunologists, cancer specialists, postdoctoral fellows and other investigators throughout the University of Cincinnati and Cincinnati Children's Hospital Medical Center.