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Department of

Dermatology

Photo of  Zalfa Abdel-Malek, PhD

Zalfa Abdel-Malek, PhD

Professor

Education/Credentials
  • Bachelor's Degree: American University of Beirut
  • Master's Degree: University of Arizona
  • Doctoral Degree: University of Arizona
  • Post Doctoral : University of Cincinnati

Contact Information
  • Medical Sciences Building
  • Room 7165
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267-0592
  • Office 513-558-6246
  • Fax 513-558-0198
  • Email zalfa.abdel-malek@uc.edu

Peer Reviewed Publications

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Abdel-Malek, Zalfa A; Cassidy, Pamela 2015. Dark CPDs and photocarcinogenesis: the party continues after the lights go out. Pigment cell & melanoma research, 28 4, 373-4

Cassidy, Pamela B; Abdel-Malek, Zalfa A; Leachman, Sancy A 2015. Beyond Red Hair and Sunburns: Uncovering the Molecular Mechanisms of MC1R Signaling and Repair of UV-Induced DNA Damage. The Journal of investigative dermatology, 135 12, 2918-21

von Koschembahr, Anne M; Swope, Viki B; Starner, Renny J; Abdel-Malek, Zalfa A 2015. Endothelin-1 Protects Human Melanocytes from UV-Induced DNA Damage by Activating JNK and p38 Signaling Pathways. Experimental dermatology, ,

Abdel-Malek, Zalfa A; Swope, Viki B; Starner, Renny J; Koikov, Leonid; Cassidy, Pamela; Leachman, Sancy 2014. Melanocortins and the melanocortin 1 receptor, moving translationally towards melanoma prevention. Archives of biochemistry and biophysics, ,

Abdel-Malek, Zalfa A; Swope, Viki B; Starner, Renny J; Koikov, Leonid; Cassidy, Pamela; Leachman, Sancy 2014. Melanocortins and the melanocortin 1 receptor, moving translationally towards melanoma prevention. Archives of biochemistry and biophysics, ,

Denat, Laurence; Kadekaro, Ana L; Marrot, Laurent; Leachman, Sancy A; Abdel-Malek, Zalfa A 2014. Melanocytes as instigators and victims of oxidative stress. The Journal of investigative dermatology, 134 6, 1512-8

Denat, Laurence; Kadekaro, Ana L; Marrot, Laurent; Leachman, Sancy A; Abdel-Malek, Zalfa A 2014. Melanocytes as instigators and victims of oxidative stress. The Journal of investigative dermatology, 134 6, 1512-8

García-Borrón, Jose C; Abdel-Malek, Zalfa; Jiménez-Cervantes, Celia 2014. MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation. Pigment cell & melanoma research, ,

García-Borrón, Jose C; Abdel-Malek, Zalfa; Jiménez-Cervantes, Celia 2014. MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation. Pigment cell & melanoma research, ,

Swope, Viki; Alexander, Christina; Starner, Renny; Schwemberger, Sandy; Babcock, George; Abdel-Malek, Zalfa A 2014. Significance of the melanocortin 1 receptor in the DNA damage response of human melanocytes to ultraviolet radiation. Pigment cell & melanoma research, 27 4, 601-10

Swope, Viki; Alexander, Christina; Starner, Renny; Schwemberger, Sandy; Babcock, George; Abdel-Malek, Zalfa A 2014. Significance of the melanocortin 1 receptor in the DNA damage response of human melanocytes to ultraviolet radiation. Pigment cell & melanoma research, 27 4, 601-10

Kadekaro, Ana Luisa; Chen, Juping; Yang, Jennifer; Chen, Shuna; Jameson, Joshua; Swope, Viki B; Cheng, Tan; Kadakia, Madhavi; Abdel-Malek, Zalfa 2012. Alpha-melanocyte-stimulating hormone suppresses oxidative stress through a p53-mediated signaling pathway in human melanocytes. Molecular cancer research : MCR, 10 6, 778-86

Kadekaro, Ana Luisa; Chen, Juping; Yang, Jennifer; Chen, Shuna; Jameson, Joshua; Swope, Viki B; Cheng, Tan; Kadakia, Madhavi; Abdel-Malek, Zalfa 2012. Alpha-melanocyte-stimulating hormone suppresses oxidative stress through a p53-mediated signaling pathway in human melanocytes. Molecular cancer research : MCR, 10 6, 778-86

Swope, Viki B; Jameson, Joshua A; McFarland, Kevin L; Supp, Dorothy M; Miller, William E; McGraw, Dennis W; Patel, Mira A; Nix, Matthew A; Millhauser, Glenn L; Babcock, George F; Abdel-Malek, Zalfa A 2012. Defining MC1R regulation in human melanocytes by its agonist ?-melanocortin and antagonists agouti signaling protein and ?-defensin 3. The Journal of investigative dermatology, 132 9, 2255-62

Swope, Viki B; Jameson, Joshua A; McFarland, Kevin L; Supp, Dorothy M; Miller, William E; McGraw, Dennis W; Patel, Mira A; Nix, Matthew A; Millhauser, Glenn L; Babcock, George F; Abdel-Malek, Zalfa A 2012. Defining MC1R regulation in human melanocytes by its agonist ?-melanocortin and antagonists agouti signaling protein and ?-defensin 3. The Journal of investigative dermatology, 132 9, 2255-62

Herraiz, Cecilia; Journé, Fabrice; Abdel-Malek, Zalfa; Ghanem, Ghanem; Jiménez-Cervantes, Celia; García-Borrón, José C 2011. Signaling from the human melanocortin 1 receptor to ERK1 and ERK2 mitogen-activated protein kinases involves transactivation of cKIT. Molecular endocrinology (Baltimore, Md.), 25 1, 138-56

Abdel-Malek, Zalfa A 2010. Development of ?-Melanocortin Analogs for Melanoma Prevention and Targeting. Advances in experimental medicine and biology, 681 , 126-32

Abdel-Malek, Zalfa A; Kadekaro, Ana Luisa; Swope, Viki B 2010. Stepping up melanocytes to the challenge of UV exposure. Pigment cell & melanoma research, 23 2, 171-86

Abdel-Malek, Zalfa; Bar-Eli, Menashe 2010. Estela Medrano, 1943-2010. Pigment cell & melanoma research, 23 6, 724

Kadekaro, Ana Luisa; Leachman, Sancy; Kavanagh, Renny J; Swope, Viki; Cassidy, Pamela; Supp, Dorothy; Sartor, Maureen; Schwemberger, Sandy; Babcock, George; Wakamatsu, Kazumasa; Ito, Shosuke; Koshoffer, Amy; Boissy, Raymond E; Manga, Prashiela; Sturm, Richard A; Abdel-Malek, Zalfa A 2010. Melanocortin 1 receptor genotype: an important determinant of the damage response of melanocytes to ultraviolet radiation. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24 10, 3850-60

Starner, Renny J; McClelland, Lindy; Abdel-Malek, Zalfa; Fricke, Alex; Scott, Glynis 2010. PGE(2) is a UVR-inducible autocrine factor for human melanocytes that stimulates tyrosinase activation. Experimental dermatology, 19 7, 682-4

Abdel-Malek, Zalfa A 2009. Agouti signal protein: crossing the 'yellow' signal and arriving to pathways that affect tumorgenesis. Pigment cell & melanoma research, 22 3, 253-4

Abdel-Malek, Zalfa A; Ruwe, Andrew; Kavanagh-Starner, Renny; Kadekaro, Ana Luisa; Swope, Viki; Haskell-Luevano, Carrie; Koikov, Leonid; Knittel, James J 2009. alpha-MSH tripeptide analogs activate the melanocortin 1 receptor and reduce UV-induced DNA damage in human melanocytes. Pigment cell & melanoma research, 22 5, 635-44

Plonka, P M; Passeron, T; Brenner, M; Tobin, D J; Shibahara, S; Thomas, A; Slominski, A; Kadekaro, A L; Hershkovitz, D; Peters, E; Nordlund, J J; Abdel-Malek, Z; Takeda, K; Paus, R; Ortonne, J P; Hearing, V J; Schallreuter, K U 2009. What are melanocytes really doing all day long...? Experimental dermatology, 18 9, 799-819

Ruwe, Andrew R; Koikov, Leonid; Abdel-Malek, Zalfa; Haskell-Luevano, Carrie; Dirain, Marvin L; Portillo, Federico; Xiang, Zhimin; Wortman, Matt; Knittel, James J 2009. Semi-rigid tripeptide agonists of melanocortin receptors. Bioorganic & medicinal chemistry letters, 19 17, 5176-81

Song, Xiuzu; Mosby, Nicole; Yang, Jennifer; Xu, Aie; Abdel-Malek, Zalfa; Kadekaro, Ana Luisa 2009. alpha-MSH activates immediate defense responses to UV-induced oxidative stress in human melanocytes. Pigment cell & melanoma research, 22 6, 809-18

Abdel-Malek, Zalfa A; Supp, Dorothy 2008. beta-Defensin 3: a novel and unexpected key that unlocks the melanocortin 1 receptor. Pigment cell & melanoma research, 21 1, 7-8

Kadekaro, Ana Luisa; Abdel-Malek, Zalfa A 2007. Walking in the footsteps of giants: melanocortins and human pigmentation, a historical perspective. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, 20 3, 150-2

Abdel-Malek, Zalfa A; Kadekaro, Ana Luisa; Kavanagh, Renny J; Todorovic, Aleksandar; Koikov, Leonid N; McNulty, Joseph C; Jackson, Pilgrim J; Millhauser, Glenn L; Schwemberger, Sandy; Babcock, George; Haskell-Luevano, Carrie; Knittel, James J 2006. Melanoma prevention strategy based on using tetrapeptide alpha-MSH analogs that protect human melanocytes from UV-induced DNA damage and cytotoxicity. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 20 9, 1561-3

Gray-Schopfer, V C; Cheong, S C; Chong, H; Chow, J; Moss, T; Abdel-Malek, Z A; Marais, R; Wynford-Thomas, D; Bennett, D C 2006. Cellular senescence in naevi and immortalisation in melanoma: a role for p16? British journal of cancer, 95 4, 496-505

Hauser, Jennifer E; Kadekaro, Ana Luisa; Kavanagh, Renny J; Wakamatsu, Kazumasa; Terzieva, Silva; Schwemberger, Sandy; Babcock, George; Rao, M B; Ito, Shosuke; Abdel-Malek, Zalfa A 2006. Melanin content and MC1R function independently affect UVR-induced DNA damage in cultured human melanocytes. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, 19 4, 303-14

Kadekaro, Ana Luisa; Wakamatsu, Kazumasa; Ito, Shosuke; Abdel-Malek, Zalfa A 2006. Cutaneous photoprotection and melanoma susceptibility: reaching beyond melanin content to the frontiers of DNA repair. Frontiers in bioscience : a journal and virtual library, 11 , 2157-73

Rouzaud, Francois; Costin, Gertrude-E; Yamaguchi, Yuji; Valencia, Julio C; Berens, Werner F; Chen, Kevin G; Hoashi, Toshihiko; Böhm, Markus; Abdel-Malek, Zalfa A; Hearing, Vincent J 2006. Regulation of constitutive and UVR-induced skin pigmentation by melanocortin 1 receptor isoforms. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 20 11, 1927-9

Wakamatsu, Kazumasa; Kavanagh, Renny; Kadekaro, Ana L; Terzieva, Silva; Sturm, Richard A; Leachman, Sancy; Abdel-Malek, Zalfa; Ito, Shosuke 2006. Diversity of pigmentation in cultured human melanocytes is due to differences in the type as well as quantity of melanin. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, 19 2, 154-62

Kadekaro, Ana Luisa; Kavanagh, Renny; Kanto, Hiromi; Terzieva, Silva; Hauser, Jennifer; Kobayashi, Nobuhiko; Schwemberger, Sandy; Cornelius, James; Babcock, George; Shertzer, Howard G; Scott, Glynis; Abdel-Malek, Zalfa A 2005. alpha-Melanocortin and endothelin-1 activate antiapoptotic pathways and reduce DNA damage in human melanocytes. Cancer research, 65 10, 4292-9

Rouzaud, Francois; Kadekaro, Ana Luisa; Abdel-Malek, Zalfa A; Hearing, Vincent J 2005. MC1R and the response of melanocytes to ultraviolet radiation. Mutation research, 571 1-2, 133-52

Todorovic, Aleksandar; Holder, Jerry Ryan; Bauzo, Rayna M; Scott, Joseph Walker; Kavanagh, Renny; Abdel-Malek, Zalfa; Haskell-Luevano, Carrie 2005. N-terminal fatty acylated His-dPhe-Arg-Trp-NH(2) tetrapeptides: influence of fatty acid chain length on potency and selectivity at the mouse melanocortin receptors and human melanocytes. Journal of medicinal chemistry, 48 9, 3328-36

Yamaguchi, Yuji; Itami, Satoshi; Watabe, Hidenori; Yasumoto, Ken-Ichi; Abdel-Malek, Zalfa A; Kubo, Tateki; Rouzaud, François; Tanemura, Atsushi; Yoshikawa, Kunihiko; Hearing, Vincent J 2004. Mesenchymal-epithelial interactions in the skin: increased expression of dickkopf1 by palmoplantar fibroblasts inhibits melanocyte growth and differentiation. The Journal of cell biology, 165 2, 275-85

Kadekaro, Ana Luisa; Kanto, Hiromi; Kavanagh, Renny; Abdel-Malek, Zalfa A 2003. Significance of the melanocortin 1 receptor in regulating human melanocyte pigmentation, proliferation, and survival. Annals of the New York Academy of Sciences, 994 , 359-65

Kadekaro, Ana Luisa; Kavanagh, Renny J; Wakamatsu, Kazumasa; Ito, Shosuke; Pipitone, Michelle A; Abdel-Malek, Zalfa A 2003. Cutaneous photobiology. The melanocyte vs. the sun: who will win the final round? Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, 16 5, 434-47

Scott, M Cathy; Suzuki, Itaru; Abdel-Malek, Zalfa A 2002. Regulation of the human melanocortin 1 receptor expression in epidermal melanocytes by paracrine and endocrine factors and by ultraviolet radiation. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, 15 6, 433-9

Scott, M Cathy; Wakamatsu, Kazumasa; Ito, Shosuke; Kadekaro, Ana Luisa; Kobayashi, Nobuhiko; Groden, Joanna; Kavanagh, Renny; Takakuwa, Takako; Virador, Victoria; Hearing, Vincent J; Abdel-Malek, Zalfa A 2002. Human melanocortin 1 receptor variants, receptor function and melanocyte response to UV radiation. Journal of cell science, 115 Pt 11, 2349-55

Tada, Akihiro; Pereira, Elizabeth; Beitner-Johnson, Dana; Kavanagh, Renny; Abdel-Malek, Zalfa A 2002. Mitogen- and ultraviolet-B-induced signaling pathways in normal human melanocytes. The Journal of investigative dermatology, 118 2, 316-22

Virador, Victoria M; Muller, Jacqueline; Wu, Xufneg; Abdel-Malek, Zalfa A; Yu, Zu-Xi; Ferrans, Victor J; Kobayashi, Nobuhiko; Wakamatsu, Kazumasa; Ito, Shosuke; Hammer, John A; Hearing, Vincent J 2002. Influence of alpha-melanocyte-stimulating hormone and ultraviolet radiation on the transfer of melanosomes to keratinocytes. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 16 1, 105-7

Abdel-Malek, Z 2001. Neuromediators and pigmentation. Experimental dermatology, 10 5, 350-1

Abdel-Malek, Z A 2001. Melanocortin receptors: their functions and regulation by physiological agonists and antagonists. Cellular and molecular life sciences : CMLS, 58 3, 434-41

Abdel-Malek, Z A; Scott, M C; Furumura, M; Lamoreux, M L; Ollmann, M; Barsh, G S; Hearing, V J 2001. The melanocortin 1 receptor is the principal mediator of the effects of agouti signaling protein on mammalian melanocytes. Journal of cell science, 114 Pt 5, 1019-24

Virador, V; Matsunaga, N; Matsunaga, J; Valencia, J; Oldham, R J; Kameyama, K; Peck, G L; Ferrans, V J; Vieira, W D; Abdel-Malek, Z A; Hearing, V J 2001. Production of melanocyte-specific antibodies to human melanosomal proteins: expression patterns in normal human skin and in cutaneous pigmented lesions. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, 14 4, 289-97

Abdel-Malek, Z; Scott, M C; Suzuki, I; Tada, A; Im, S; Lamoreux, L; Ito, S; Barsh, G; Hearing, V J 2000. The melanocortin-1 receptor is a key regulator of human cutaneous pigmentation. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, 13 Suppl 8 , 156-62

Abdel-Malek, Z; Suzuki, I; Tada, A; Im, S; Akcali, C 1999. The melanocortin-1 receptor and human pigmentation. Annals of the New York Academy of Sciences, 885 , 117-33

Suzuki, I; Im, S; Tada, A; Scott, C; Akcali, C; Davis, M B; Barsh, G; Hearing, V; Abdel-Malek, Z 1999. Participation of the melanocortin-1 receptor in the UV control of pigmentation. The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research, 4 1, 29-34

Can, G; Abdel-Malek, Z; Porter-Gill, P A; Gill, P; Boyce, S; Grabowski, G A; Nordlund, J; Farooqui, J 1998. Identification and sequencing of a putative variant of proopiomelanocortin in human epidermis and epidermal cells in culture. The Journal of investigative dermatology, 111 3, 485-91

Im, S; Moro, O; Peng, F; Medrano, E E; Cornelius, J; Babcock, G; Nordlund, J J; Abdel-Malek, Z A 1998. Activation of the cyclic AMP pathway by alpha-melanotropin mediates the response of human melanocytes to ultraviolet B radiation. Cancer research, 58 1, 47-54

Tada, A; Suzuki, I; Im, S; Davis, M B; Cornelius, J; Babcock, G; Nordlund, J J; Abdel-Malek, Z A 1998. Endothelin-1 is a paracrine growth factor that modulates melanogenesis of human melanocytes and participates in their responses to ultraviolet radiation. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 9 7, 575-84

Sakai, C; Ollmann, M; Kobayashi, T; Abdel-Malek, Z; Muller, J; Vieira, W D; Imokawa, G; Barsh, G S; Hearing, V J 1997. Modulation of murine melanocyte function in vitro by agouti signal protein. The EMBO journal, 16 12, 3544-52

Scott, G; Cassidy, L; Abdel-Malek, Z 1997. Alpha-melanocyte-stimulating hormone and endothelin-1 have opposing effects on melanocyte adhesion, migration, and pp125FAK phosphorylation. Experimental cell research, 237 1, 19-28

Suzuki, I; Tada, A; Ollmann, M M; Barsh, G S; Im, S; Lamoreux, M L; Hearing, V J; Nordlund, J J; Abdel-Malek, Z A 1997. Agouti signaling protein inhibits melanogenesis and the response of human melanocytes to alpha-melanotropin. The Journal of investigative dermatology, 108 6, 838-42

Furumura, M; Sakai, C; Abdel-Malek, Z; Barsh, G S; Hearing, V J 1996. The interaction of agouti signal protein and melanocyte stimulating hormone to regulate melanin formation in mammals. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, 9 4, 191-203

Suzuki, I; Cone, R D; Im, S; Nordlund, J; Abdel-Malek, Z A 1996. Binding of melanotropic hormones to the melanocortin receptor MC1R on human melanocytes stimulates proliferation and melanogenesis. Endocrinology, 137 5, 1627-33

Abdel-Malek, Z; Swope, V B; Suzuki, I; Akcali, C; Harriger, M D; Boyce, S T; Urabe, K; Hearing, V J 1995. Mitogenic and melanogenic stimulation of normal human melanocytes by melanotropic peptides. Proceedings of the National Academy of Sciences of the United States of America, 92 5, 1789-93

Barker, D; Dixon, K; Medrano, E E; Smalara, D; Im, S; Mitchell, D; Babcock, G; Abdel-Malek, Z A 1995. Comparison of the responses of human melanocytes with different melanin contents to ultraviolet B irradiation. Cancer research, 55 18, 4041-6

Medrano, E E; Im, S; Yang, F; Abdel-Malek, Z A 1995. Ultraviolet B light induces G1 arrest in human melanocytes by prolonged inhibition of retinoblastoma protein phosphorylation associated with long-term expression of the p21Waf-1/SDI-1/Cip-1 protein. Cancer research, 55 18, 4047-52

Swope, V B; Medrano, E E; Smalara, D; Abdel-Malek, Z A 1995. Long-term proliferation of human melanocytes is supported by the physiologic mitogens alpha-melanotropin, endothelin-1, and basic fibroblast growth factor. Experimental cell research, 217 2, 453-9

Abdel-Malek, Z A; Swope, V B; Nordlund, J J; Medrano, E E 1994. Proliferation and propagation of human melanocytes in vitro are affected by donor age and anatomical site. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, 7 2, 116-22

Abdel-Malek, Z; Swope, V; Smalara, D; Babcock, G; Dawes, S; Nordlund, J 1994. Analysis of the UV-induced melanogenesis and growth arrest of human melanocytes. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, 7 5, 326-32

Swope, V B; Sauder, D N; McKenzie, R C; Sramkoski, R M; Krug, K A; Babcock, G F; Nordlund, J J; Abdel-Malek, Z A 1994. Synthesis of interleukin-1 alpha and beta by normal human melanocytes. The Journal of investigative dermatology, 102 5, 749-53

Zhao, H; Boissy, Y L; Abdel-Malek, Z; King, R A; Nordlund, J J; Boissy, R E 1994. On the analysis of the pathophysiology of Chediak-Higashi syndrome. Defects expressed by cultured melanocytes. Laboratory investigation; a journal of technical methods and pathology, 71 1, 25-34

Abdel-Malek, Z; Swope, V; Collins, C; Boissy, R; Zhao, H; Nordlund, J 1993. Contribution of melanogenic proteins to the heterogeneous pigmentation of human melanocytes. Journal of cell science, 106 ( Pt 4) , 1323-31

Boyce, S T; Medrano, E E; Abdel-Malek, Z; Supp, A P; Dodick, J M; Nordlund, J J; Warden, G D 1993. Pigmentation and inhibition of wound contraction by cultured skin substitutes with adult melanocytes after transplantation to athymic mice. The Journal of investigative dermatology, 100 4, 360-5

Farooqui, J Z; Medrano, E E; Abdel-Malek, Z; Nordlund, J 1993. The expression of proopiomelanocortin and various POMC-derived peptides in mouse and human skin. Annals of the New York Academy of Sciences, 680 , 508-10

Abdel-Malek, Z A; Swope, V B; Nordlund, J J 1992. The nature and biological effects of factors responsible for proliferation and differentiation of melanocytes. Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society, Suppl 2 , 43-7

Abdel-Malek, Z; Swope, V B; Pallas, J; Krug, K; Nordlund, J J 1992. Mitogenic, melanogenic, and cAMP responses of cultured neonatal human melanocytes to commonly used mitogens. Journal of cellular physiology, 150 2, 416-25

Plews, P I; Abdel-Malek, Z A; Doupnik, C A; Leikauf, G D 1991. Endothelin stimulates chloride secretion across canine tracheal epithelium. The American journal of physiology, 261 2 Pt 1, L188-94

Swope, V B; Abdel-Malek, Z; Kassem, L M; Nordlund, J J 1991. Interleukins 1 alpha and 6 and tumor necrosis factor-alpha are paracrine inhibitors of human melanocyte proliferation and melanogenesis. The Journal of investigative dermatology, 96 2, 180-5

Abdel-Malek, Z A; Swope, V B; Trinkle, L S; Nordlund, J J 1989. Stimulation of Cloudman melanoma tyrosinase activity occurs predominantly in G2 phase of the cell cycle. Experimental cell research, 180 1, 198-208

Nordlund, J J; Abdel-Malek, Z A; Boissy, R E; Rheins, L A 1989. Pigment cell biology: an historical review. The Journal of investigative dermatology, 92 4 Suppl, 53S-60S

Swope, V B; Abdel-Malek, Z A; Sauder, D N; Nordlund, J J 1989. A new role for epidermal cell-derived thymocyte activating factor/IL-1 as an antagonist for distinct epidermal cell function. Journal of immunology (Baltimore, Md. : 1950), 142 6, 1943-9

Abdel-Malek, Z A 1988. Endocrine factors as effectors of integumental pigmentation. Dermatologic clinics, 6 2, 175-83

Abdel-Malek, Z A; Ross, R; Trinkle, L; Swope, V; Pike, J W; Nordlund, J J 1988. Hormonal effects of vitamin D3 on epidermal melanocytes. Journal of cellular physiology, 136 2, 273-80

Abdel-Malek, Z A; Swope, V B; Trinkle, L S; Ferroni, E N; Boissy, R E; Nordlund, J J 1988. Alteration of the Cloudman melanoma cell cycle by prostaglandins E1 and E2 determined by using a 5-bromo-2'-deoxyuridine method of DNA analysis. Journal of cellular physiology, 136 2, 247-56

Nordlund, J J; Abdel-Malek, Z A 1988. Mechanisms for post-inflammatory hyperpigmentation and hypopigmentation. Progress in clinical and biological research, 256 , 219-36

Trinkle, L S; Swope, V B; Abdel-Malek, Z A; Nordlund, J J 1988. Differentiation of mitotic melanoma cells from G2 cells and their isolation by use of 5-bromo-2'-deoxyuridine and propidium iodide. Cytometry, 9 5, 432-5

Abdel-Malek, Z A; Swope, V B; Amornsiripanitch, N; Nordlund, J J 1987. In vitro modulation of proliferation and melanization of S91 melanoma cells by prostaglandins. Cancer research, 47 12, 3141-6

Levine, N; Lemus-Wilson, A; Wood, S H; Abdel Malek, Z A; Al-Obeidi, F; Hruby, V J; Hadley, M E 1987. Stimulation of follicular melanogenesis in the mouse by topical and injected melanotropins. The Journal of investigative dermatology, 89 3, 269-73

Abdel Malek, Z A; Hadley, M E; Bregman, M D; Meyskens, F L; Hruby, V J 1986. Actions of melanotropins on mouse melanoma cell growth in vitro. Journal of the National Cancer Institute, 76 5, 857-63

Abdel Malek, Z A; Kreutzfeld, K L; Hadley, M E; Bregman, M D; Hruby, V J; Meyskens, F L 1986. Long-term and residual melanotropin-stimulated tyrosinase activity in S91 melanoma cells is density dependent. In vitro cellular & developmental biology : journal of the Tissue Culture Association, 22 2, 75-81

Sugg, E E; Cody, W L; Abdel-Malek, Z; Hadley, M E; Hruby, V J 1986. D-isomeric replacements within the 6-9 core sequence of Ac-[Nle4]-alpha-MSH4-11-NH2: a topological model for the solution conformation of alpha-melanotropin. Biopolymers, 25 11, 2029-42

Abdel Malek, Z A; Kreutzfeld, K L; Marwan, M M; Hadley, M E; Hruby, V J; Wilkes, B C 1985. Prolonged stimulation of S91 melanoma tyrosinase by [Nle4, D-Phe7]-substituted alpha-melanotropins. Cancer research, 45 10, 4735-40

Bregman, M D; Abdel Malek, Z A; Meyskens, F L 1985. Anchorage-independent growth of murine melanoma in serum-less media is dependent on insulin or melanocyte-stimulating hormone. Experimental cell research, 157 2, 419-28

Hadley, M E; Abdel Malek, Z A; Marwan, M M; Kreutzfeld, K L; Hruby, V J 1985. [Nle4, D-Phe7]-alpha-MSH: a superpotent melanotropin that "irreversibly" activates melanoma tyrosinase. Endocrine research, 11 3-4, 157-70

Marwan, M M; Abdel Malek, Z A; Kreutzfeld, K L; Hadley, M E; Wilkes, B C; Hruby, V J; Castrucci, A M 1985. Stimulation of S91 melanoma tyrosinase activity by superpotent alpha-melanotropins. Molecular and cellular endocrinology, 41 2-3, 171-7

Abdel-Malek, Zalfa A; Knittel, James; Kadekaro, Ana Luisa; Swope, Viki B; Starner, Renny . The melanocortin 1 receptor and the UV response of human melanocytes--a shift in paradigm. Photochemistry and photobiology, 84 2, 501-8

Ghanem, G; Loir, B; Hadley, M; Abdel Malek, Z; Libert, A; Del Marmol, V; Lejeune, F; Lozano, J; García-Borron, J C . Partial characterization of IR-alpha-MSH peptides found in melanoma tumors. Peptides, 13 5, 989-94

Yang, F; Abdel-Malek, Z; Boissy, R E . Effects of commonly used mitogens on the cytotoxicity of 4-tertiary butylphenol to human melanocytes. In vitro cellular & developmental biology. Animal, 35 10, 566-70