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Department of

Cancer Biology

Photo of  Nira Ben-Jonathan, PhD

Nira Ben-Jonathan, PhD

Professor

Education/Credentials
  • Bachelor's Degree: Tel Aviv University
  • Master's Degree: University of Illinois
  • Doctoral Degree: University of Illinois

Research/Clinical Interests

Research interests include: 1) roles of hormones in breast and head and neck cancer; 2) regulation of adipose tissue functions and human obesity; 3) effects of endocrine disruptors on multiple physiological processes.

Contact Information
  • Vontz Center for Molecular Studies
  • 3125 Eden Avenue
  • ML 0521
  • Cincinnati, Ohio 45267
  • Office 513-558-4821
  • Email nira.ben-jonathan@uc.edu

Peer Reviewed Publications

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Tuttle, Traci R; Takiar, Vinita; Kumar, Bhavna; Kumar, Pawan; Ben-Jonathan, Nira 2017. Soluble guanylate cyclase stimulators increase sensitivity to cisplatin in head and neck squamous cell carcinoma cells. Cancer letters, 389 , 33-40

Ben-Jonathan N, Hugo ER 2016. Bisphenols Come in Different Flavors: Is "S" Better Than "A"? Endocrinology, 157 , 1321-1323

Ben-Jonathan, Nira; Hugo, Eric R 2016. Bisphenols Come in Different Flavors: Is "S" Better Than "A"? Endocrinology, 157 4, 1321-3

Borcherding DC, Tong W, Hugo ER, Barnard DF, Fox S, LaSance K, Shaughnessy E, Ben-Jonathan N 2016. Expression and therapeutic applications of dopamine receptor-1 (D1R) in breast cancer Oncogene, 35 , 3103-3113

Tuttle, Traci R; Mierzwa, Michelle L; Wells, Susanne I; Fox, Sejal R; Ben-Jonathan, Nira 2016. The cyclic GMP/protein kinase G pathway as a therapeutic target in head and neck squamous cell carcinoma. Cancer letters, 370 2, 279-85

Ben-Jonathan, Nira; Hugo, Eric 2015. Prolactin (PRL) in adipose tissue: regulation and functions. Advances in experimental medicine and biology, 846 , 1-35

Garrison, Jason B; Ge, Chunmin; Che, Lixiao; Pullum, Derek A; Peng, Guang; Khan, Sohaib; Ben-Jonathan, Nira; Wang, Jiang; Du, Chunying 2015. Knockdown of the Inhibitor of Apoptosis BRUCE Sensitizes Resistant Breast Cancer Cells to Chemotherapeutic Agents. Journal of cancer science & therapy, 7 4, 121-126

Marano, Robert J; Ben-Jonathan, Nira 2014. Minireview: extrapituitary prolactin: an update on the distribution, regulation, and functions. Molecular endocrinology (Baltimore, Md.), 28 5, 622-33

Tuttle, TR; Hugo, ER; Tong, WS; Ben-Jonathan, N 2014. Placental lactogen is expressed but is not translated into protein in breast cancer PloS One, 9 1, e87325

Lo, Yuan-Hung; Ho, Po-Chun; Chen, Min-Shan; Hugo, Eric; Ben-Jonathan, Nira; Wang, Shao-Chun 2013. Phosphorylation at tyrosine 114 of Proliferating Cell Nuclear Antigen (PCNA) is required for adipogenesis in response to high fat diet. Biochemical and biophysical research communications, 430 1, 43-8

Villarroel, Pia; Reyes, Marcela; Fuentes, Cecilia; Segovia, María Pia; Tobar, Nicolás; Villalobos, Elisa; Martínez, Jorge; Hugo, Eric; Ben-Jonathan, Nira; Cifuentes, Mariana 2013. Adipogenic effect of calcium sensing receptor activation. Molecular and cellular biochemistry, 384 1-2, 139-45

Cifuentes, Mariana; Fuentes, Cecilia; Tobar, Nicolas; Acevedo, Ingrid; Villalobos, Elisa; Hugo, Eric; Ben-Jonathan, Nira; Reyes, Marcela 2012. Calcium sensing receptor activation elevates proinflammatory factor expression in human adipose cells and adipose tissue. Molecular and cellular endocrinology, 361 1-2, 24-30

Borcherding, Dana C; Hugo, Eric R; Idelman, Gila; De Silva, Anuradha; Richtand, Nathan W; Loftus, Jean; Ben-Jonathan, Nira 2011. Dopamine receptors in human adipocytes: expression and functions. PloS one, 6 9, e25537

Idelman, Gila; Jacobson, Eric M; Tuttle, Traci R; Ben-Jonathan, Nira 2011. Lactogens and estrogens in breast cancer chemoresistance. Expert review of endocrinology & metabolism, 6 3, 411-422

Jacobson, Eric M; Hugo, Eric R; Borcherding, Dana C; Ben-Jonathan, Nira 2011. Prolactin in breast and prostate cancer: molecular and genetic perspectives. Discovery medicine, 11 59, 315-24

Cifuentes, Mariana; Fuentes, Cecilia; Mattar, Pamela; Tobar, Nicolas; Hugo, Eric; Ben-Jonathan, Nira; Rojas, Cecilia; Martínez, Jorge 2010. Obesity-associated proinflammatory cytokines increase calcium sensing receptor (CaSR) protein expression in primary human adipocytes and LS14 human adipose cell line. Archives of biochemistry and biophysics, 500 2, 151-6

Jacobson, Eric M; Hugo, Eric R; Tuttle, Traci R; Papoian, Ruben; Ben-Jonathan, Nira 2010. Unexploited therapies in breast and prostate cancer: blockade of the prolactin receptor. Trends in endocrinology and metabolism: TEM, 21 11, 691-8

Kansra, Sanjay; Chen, Shenglin; Bangaru, Madhavi Latha Yadav; Sneade, Leighton; Dunckley, Joseph A; Ben-Jonathan, Nira 2010. Selective estrogen receptor down-regulator and selective estrogen receptor modulators differentially regulate lactotroph proliferation. PloS one, 5 4, e10060

LaPensee, Elizabeth W; Ben-Jonathan, Nira 2010. Novel roles of prolactin and estrogens in breast cancer: resistance to chemotherapy. Endocrine-related cancer, 17 2, R91-107

LaPensee, Elizabeth W; LaPensee, Christopher R; Fox, Sejal; Schwemberger, Sandy; Afton, Scott; Ben-Jonathan, Nira 2010. Bisphenol A and estradiol are equipotent in antagonizing cisplatin-induced cytotoxicity in breast cancer cells. Cancer letters, 290 2, 167-73

Ben-Jonathan, Nira; Chen, Shenglin; Dunckley, Joseph A; LaPensee, Christopher; Kansra, Sanjay 2009. Estrogen receptor-alpha mediates the epidermal growth factor-stimulated prolactin expression and release in lactotrophs. Endocrinology, 150 2, 795-802

Ben-Jonathan, Nira; Hugo, Eric R; Brandebourg, Terry D 2009. Effects of bisphenol A on adipokine release from human adipose tissue: Implications for the metabolic syndrome. Molecular and cellular endocrinology, 304 1-2, 49-54

Chen, Shenglin; Bangaru, Madhavi Latha Yadav; Sneade, Leighton; Dunckley, Joseph A; Ben-Jonathan, Nira; Kansra, Sanjay 2009. Epidermal growth factor receptor cross-talks with ligand-occupied estrogen receptor-alpha to modulate both lactotroph proliferation and prolactin gene expression. American journal of physiology. Endocrinology and metabolism, 297 2, E331-9

LaPensee, Elizabeth W; Schwemberger, Sandy J; LaPensee, Christopher R; Bahassi, El Mustapha; Afton, Scott E; Ben-Jonathan, Nira 2009. Prolactin confers resistance against cisplatin in breast cancer cells by activating glutathione-S-transferase. Carcinogenesis, 30 8, 1298-304

Lapensee, Elizabeth W; Tuttle, Traci R; Fox, Sejal R; Ben-Jonathan, Nira 2009. Bisphenol A at low nanomolar doses confers chemoresistance in estrogen receptor-alpha-positive and -negative breast cancer cells. Environmental health perspectives, 117 2, 175-80

Ben-Jonathan, Nira; LaPensee, Christopher R; LaPensee, Elizabeth W 2008. What can we learn from rodents about prolactin in humans? Endocrine reviews, 29 1, 1-41

Hugo, Eric R; Borcherding, Dana C; Gersin, Keith S; Loftus, Jean; Ben-Jonathan, Nira 2008. Prolactin release by adipose explants, primary adipocytes, and LS14 adipocytes. The Journal of clinical endocrinology and metabolism, 93 10, 4006-12

Hugo, Eric R; Brandebourg, Terry D; Woo, Jessica G; Loftus, Jean; Alexander, J Wesley; Ben-Jonathan, Nira 2008. Bisphenol A at environmentally relevant doses inhibits adiponectin release from human adipose tissue explants and adipocytes. Environmental health perspectives, 116 12, 1642-7

LaPensee, Christopher R; Hugo, Eric R; Ben-Jonathan, Nira 2008. Insulin stimulates interleukin-6 expression and release in LS14 human adipocytes through multiple signaling pathways. Endocrinology, 149 11, 5415-22

Brandebourg, Terry D; Bown, Jenna L; Ben-Jonathan, Nira 2007. Prolactin upregulates its receptors and inhibits lipolysis and leptin release in male rat adipose tissue. Biochemical and biophysical research communications, 357 2, 408-13

LaPensee, Elizabeth W; Reddy, Shamantha P; Hugo, Eric R; Schwemberger, Sandy J; Ben-Jonathan, Nira 2007. LS14 cells: a model for chemoresistance in liposarcoma. Cancer biology & therapy, 6 4, 519-24

Ben-Jonathan, Nira; Hugo, Eric R; Brandebourg, Terry D; LaPensee, Christopher R 2006. Focus on prolactin as a metabolic hormone. Trends in endocrinology and metabolism: TEM, 17 3, 110-6

Hnasko, Robert; Frank, Philippe G; Ben-Jonathan, Nira; Lisanti, Michael P 2006. PV-1 is negatively regulated by VEGF in the lung of caveolin-1, but not caveolin-2, null mice. Cell cycle (Georgetown, Tex.), 5 17, 2012-20

Hugo, Eric R; Brandebourg, Terry D; Comstock, Clay E S; Gersin, Keith S; Sussman, Jeffrey J; Ben-Jonathan, Nira 2006. LS14: a novel human adipocyte cell line that produces prolactin. Endocrinology, 147 1, 306-13

LaPensee, Christopher R; Horseman, Nelson D; Tso, Patrick; Brandebourg, Terry D; Hugo, Eric R; Ben-Jonathan, Nira 2006. The prolactin-deficient mouse has an unaltered metabolic phenotype. Endocrinology, 147 10, 4638-45

McFarland-Mancini, Molly; Hugo, Eric; Loftus, Jean; Ben-Jonathan, Nira 2006. Induction of prolactin expression and release in human preadipocytes by cAMP activating ligands. Biochemical and biophysical research communications, 344 1, 9-16

Ben-Jonathan, Nira 2005. Dopamine and transforming growth factor-beta1: an odd couple in growth inhibition of the lactotrophs. Endocrinology, 146 10, 4177-8

Hnasko, Robert; Ben-Jonathan, Nira 2005. Developmental regulation of PV-1 in rat lung: association with the nuclear envelope and limited colocalization with Cav-1. American journal of physiology. Lung cellular and molecular physiology, 288 2, L275-84

Kansra, Sanjay; Yamagata, Sayaka; Sneade, Leighton; Foster, Lauren; Ben-Jonathan, Nira 2005. Differential effects of estrogen receptor antagonists on pituitary lactotroph proliferation and prolactin release. Molecular and cellular endocrinology, 239 1-2, 27-36

Liby, Karen; Neltner, Bonnie; Mohamet, Lisa; Menchen, Lindsey; Ben-Jonathan, Nira 2003. Prolactin overexpression by MDA-MB-435 human breast cancer cells accelerates tumor growth. Breast cancer research and treatment, 79 2, 241-52

Zinger, Michael; McFarland, Molly; Ben-Jonathan, Nira 2003. Prolactin expression and secretion by human breast glandular and adipose tissue explants. The Journal of clinical endocrinology and metabolism, 88 2, 689-96

Ben-Jonathan, Nira; Liby, Karen; McFarland, Molly; Zinger, Michael 2002. Prolactin as an autocrine/paracrine growth factor in human cancer. Trends in endocrinology and metabolism: TEM, 13 6, 245-50

Hnasko, Robert; Ben-Jonathan, Nira . Prolactin regulation by heparin-binding growth factors expressed in mouse pituitary cell lines. Endocrine, 20 1-2, 35-44

Liby, Karen; Neltner, Bonnie; Mohamet, Lisa; Burd, Craig; Ben-Jonathan, Nira . Endostatin expression by MDA-MB-435 breast cancer cells effectively inhibits tumor growth. Cancer biology & therapy, 2 1, 48-52