Education/CredentialsPost-Doctoral Degree: Tata Institute of Fundamental Research (Molecular Biology)Doctoral Degree: Aligarh University (Biochemistry )Master's Degree: Aligarh University (Biochemistry )Bachelor's Degree: Aligarh University (Chemistry, Biology ) Contact Information Email khansa@ucmail.uc.edu Research Interests1) To understand the mechanism by which cells control the level of cholesterol in the body, we are studying the transcriptional regulation of the rat HMG-CoA reductase (HMGR) gene. HMGR is the rate limiting enzyme of cellular cholesterol synthesis. 2) Inthe second project, we are studying the role insulin plays in the regulation of glycogen phosphorylase gene. 3) In the other project underway, we are studying the role oncogenes play in cell differentiation. Peer Reviewed Publications Kadel, Sapana; Ainsua-Enrich, Erola; Hatipoglu, Ibrahim; Turner, Sean; Singh, Simar; Khan, Sohaib; Kovats, Susan 2018. A Major Population of Functional KLRG1- ILC2s in Female Lungs Contributes to a Sex Bias in ILC2 Numbers. ImmunoHorizons, 2 2, 74-86Zhang, Jinsong; Gow, Chien-Hung; Khan, Sohaib; Liu, Ying; Yang, Chuanwei 2017. Transcriptional and Genomic Control of Stem Cells in Development and Cancer. Stem cells international, 2017 , 2513598Garrison, Jason B; Ge, Chunmin; Che, Lixiao; Pullum, Derek A; Peng, Guang; Khan, Sohaib; Ben-Jonathan, Nira; Wang, Jiang; Du, Chunying 2015. Knockdown of the Inhibitor of Apoptosis BRUCE Sensitizes Resistant Breast Cancer Cells to Chemotherapeutic Agents. Journal of cancer science & therapy, 7 4, 121-126Vallabhapurapu, Subrahmanya D; Noothi, Sunil K; Pullum, Derek A; Lawrie, Charles H; Pallapati, Rachel; Potluri, Veena; Kuntzen, Christian; Khan, Sohaib; Plas, David R; Orlowski, Robert Z; Chesi, Marta; Kuehl, W Michael; Bergsagel, P Leif; Karin, Michael; Vallabhapurapu, Sivakumar 2015. Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth. Nature communications, 6 , 8428Feng, Yuxin; Singleton, David; Guo, Chun; Gardner, Amanda; Pakala, Suresh; Kumar, Rakesh; Jensen, Elwood; Zhang, Jinsong; Khan, Sohaib 2013. DNA homologous recombination factor SFR1 physically and functionally interacts with estrogen receptor alpha. PloS one, 8 7, e68075Guo, Chun; Gow, Chien-Hung; Li, Yali; Gardner, Amanda; Khan, Sohaib; Zhang, Jinsong 2012. Regulated clearance of histone deacetylase 3 protects independent formation of nuclear receptor corepressor complexes. The Journal of biological chemistry, 287 15, 12111-20Marshall, Aaron M; McClaine, Rebecca J; Gurusamy, Devikala; Gray, Jerilyn K; Lewnard, Kara E; Khan, Sohaib A; Waltz, Susan E 2012. Estrogen receptor alpha deletion enhances the metastatic phenotype of Ron overexpressing mammary tumors in mice. Molecular cancer, 11 , 2Jiang, Pingping; Hu, Qiuping; Ito, Mitsuhiro; Meyer, Sara; Waltz, Susan; Khan, Sohaib; Roeder, Robert G; Zhang, Xiaoting 2010. Key roles for MED1 LxxLL motifs in pubertal mammary gland development and luminal-cell differentiation. Proceedings of the National Academy of Sciences of the United States of America, 107 15, 6765-70Khan, Sohaib; Lingrel, Jerry B 2010. Thematic minireview series on nuclear receptors in biology and diseases. The Journal of biological chemistry, 285 50, 38741-2Naciff, Jorge M; Khambatta, Zubin S; Reichling, Timothy D; Carr, Gregory J; Tiesman, Jay P; Singleton, David W; Khan, Sohaib A; Daston, George P 2010. The genomic response of Ishikawa cells to bisphenol A exposure is dose- and time-dependent. Toxicology, 270 2-3, 137-49Khan, Shah-Naz Hayat; Abruzzo, Todd A; Ringer, Andrew J 2009. Successful endovascular reconstruction of acutely ruptured pseudoaneurysm of the vertebral artery, complicated by isolated vertebrobasilar circulation and symptomatic vasospasm. Clinical neurology and neurosurgery, 111 10, 868-73Naciff, Jorge M; Khambatta, Zubin S; Thomason, Ryan G; Carr, Gregory J; Tiesman, Jay P; Singleton, David W; Khan, Sohaib A; Daston, George P 2009. The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicological sciences : an official journal of the Society of Toxicology, 107 1, 40-55Kojetin, Douglas J; Burris, Thomas P; Jensen, Elwood V; Khan, Sohaib A 2008. Implications of the binding of tamoxifen to the coactivator recognition site of the estrogen receptor. Endocrine-related cancer, 15 4, 851-70Tharakan, Robin; Lepont, Pierig; Singleton, David; Kumar, Rakesh; Khan, Sohaib 2008. Phosphorylation of estrogen receptor alpha, serine residue 305 enhances activity. Molecular and cellular endocrinology, 295 1-2, 70-8Yang, Jun; Singleton, David W; Shaughnessy, Elizabeth A; Khan, Sohaib A 2008. The F-domain of estrogen receptor-alpha inhibits ligand induced receptor dimerization. Molecular and cellular endocrinology, 295 1-2, 94-100Feng, Yuxin; Manka, David; Wagner, Kay-Uwe; Khan, Sohaib A 2007. Estrogen receptor-alpha expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice. Proceedings of the National Academy of Sciences of the United States of America, 104 37, 14718-23Ingraham, Susan E; Lynch, Roy A; Surti, Urvashi; Rutter, Joni L; Buckler, Alan J; Khan, Sohaib A; Menon, Anil G; Lepont, Pierig 2006. Identification and characterization of novel human transcripts embedded within HMGA2 in t(12;14)(q15;q24.1) uterine leiomyoma. Mutation research, 602 1-2, 43-53Singleton, David W; Feng, Yuxin; Yang, Jun; Puga, Alvaro; Lee, Adrian V; Khan, Sohaib A 2006. Gene expression profiling reveals novel regulation by bisphenol-A in estrogen receptor-alpha-positive human cells. Environmental research, 100 1, 86-92Singleton, David W; Feng, Yuxin; Chen, Yangde; Busch, Steve J; Lee, Adrian V; Puga, Alvaro; Khan, Sohaib A 2004. Bisphenol-A and estradiol exert novel gene regulation in human MCF-7 derived breast cancer cells. Molecular and cellular endocrinology, 221 1-2, 47-55Sheeler, Cameron Q; Singleton, David W; Khan, Sobhaib A 2003. Mutation of serines 104, 106, and 118 inhibits dimerization of the human estrogen receptor in yeast. Endocrine research, 29 2, 237-55Singleton, David W; Feng, Yuxin; Burd, Craig J; Khan, Sohaib A 2003. Nongenomic activity and subsequent c-fos induction by estrogen receptor ligands are not sufficient to promote deoxyribonucleic acid synthesis in human endometrial adenocarcinoma cells. Endocrinology, 144 1, 121-8Singleton, David W; Khan, Sohaib A 2003. Xenoestrogen exposure and mechanisms of endocrine disruption. Frontiers in bioscience : a journal and virtual library, 8 , s110-8Dudley, M W; Sheeler, C Q; Wang, H; Khan, S 2000. Activation of the human estrogen receptor by the antiestrogens ICI 182,780 and tamoxifen in yeast genetic systems: implications for their mechanism of action. Proceedings of the National Academy of Sciences of the United States of America, 97 7, 3696-701Nephew, K P; Choi, C M; Polek, T C; McBride, R; Bigsby, R M; Khan, S A; Husseinzadeh, N 2000. Expression of fos and jun proto-oncogenes in benign versus malignant human uterine tissue. Gynecologic oncology, 76 3, 388-96Puga, A; Barnes, S J; Chang, C; Zhu, H; Nephew, K P; Khan, S A; Shertzer, H G 2000. Activation of transcription factors activator protein-1 and nuclear factor-kappaB by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochemical pharmacology, 59 8, 997-1005Sheeler, C Q; Dudley, M W; Khan, S A 2000. Environmental estrogens induce transcriptionally active estrogen receptor dimers in yeast: activity potentiated by the coactivator RIP140. Environmental health perspectives, 108 2, 97-103Peters, G A; Khan, S A 1999. Estrogen receptor domains E and F: role in dimerization and interaction with coactivator RIP-140. Molecular endocrinology (Baltimore, Md.), 13 2, 286-96Wang, H; Zeng, X; Khan, S A 1999. Estrogen receptor variants ERdelta5 and ERdelta7 down-regulate wild-type estrogen receptor activity. Molecular and cellular endocrinology, 156 1-2, 159-68Allen, D L; Mitchner, N A; Uveges, T E; Nephew, K P; Khan, S; Ben-Jonathan, N 1997. Cell-specific induction of c-fos expression in the pituitary gland by estrogen. Endocrinology, 138 5, 2128-35Moulton, B C; Motz, J; Serdoncillo, C; Akcali, K C; Khan, S A 1997. Progesterone withdrawal and RU-486 treatment stimulate apoptosis in specific uterine decidual cells. Cell death and differentiation, 4 1, 76-81Akcali, K C; Khan, S A; Moulton, B C 1996. Effect of decidualization on the expression of bax and bcl-2 in the rat uterine endometrium. Endocrinology, 137 7, 3123-31Meng, J J; Khan, S; Ip, W 1996. Intermediate filament protein domain interactions as revealed by two-hybrid screens. The Journal of biological chemistry, 271 3, 1599-604Nephew, K P; Polek, T C; Khan, S A 1996. Tamoxifen-induced proto-oncogene expression persists in uterine endometrial epithelium. Endocrinology, 137 1, 219-24Nephew, K P; Peters, G A; Khan, S A 1995. Cellular localization of estradiol-induced c-fos messenger ribonucleic acid in the rat uterus: c-fos expression and uterine cell proliferation do not correlate strictly. Endocrinology, 136 7, 3007-15Wang, H; Peters, G A; Zeng, X; Tang, M; Ip, W; Khan, S A 1995. Yeast two-hybrid system demonstrates that estrogen receptor dimerization is ligand-dependent in vivo. The Journal of biological chemistry, 270 40, 23322-9Makarova, I; Carpenter, D; Khan, S; Ip, W 1994. A conserved region in the tail domain of vimentin is involved in its assembly into intermediate filaments. Cell motility and the cytoskeleton, 28 3, 265-77Meng, J J; Khan, S; Ip, W 1994. Charge interactions in the rod domain drive formation of tetramers during intermediate filament assembly. The Journal of biological chemistry, 269 28, 18679-85Nephew, K P; Tang, M; Khan, S A 1994. Estrogen differentially affects c-jun expression in uterine tissue compartments. Endocrinology, 134 4, 1827-34Cho, F S; Phillips, K S; Khan, S A; Weaver, T E 1993. Cloning of the rat cyclin-dependent kinase 4 cDNA: implication in proliferation-dependent expression in rat tissues. Biochemical and biophysical research communications, 191 3, 860-5Nephew, K P; Polek, T C; Akcali, K C; Khan, S A 1993. The antiestrogen tamoxifen induces c-fos and jun-B, but not c-jun or jun-D, protooncogenes in the rat uterus. Endocrinology, 133 1, 419-22Nephew, K P; Webb, D K; Akcali, K C; Moulton, B C; Khan, S A 1993. Hormonal regulation and expression of the jun-D protooncogene in specific cell types of the rat uterus. The Journal of steroid biochemistry and molecular biology, 46 3, 281-7Webb, D K; Moulton, B C; Khan, S A 1993. Estrogen induces expression of c-jun and jun-B protooncogenes in specific rat uterine cells. Endocrinology, 133 1, 20-8Moulton, B C; Khan, S A 1992. Progestin and estrogen control of cathepsin D expression and processing in rat uterine luminal epithelium and stroma-myometrium. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 201 1, 98-105Raza, A; Yousuf, N; Bokhari, S A; Mehdi, A; Masterson, M; Lampkin, B; Yanik, G; Mazewski, C; Khan, S; Preisler, H 1992. Contribution of in vivo proliferation/differentiation studies toward the development of a combined functional and morphologic system of classification of neoplastic diseases. Cancer, 69 6 Suppl, 1557-66Dungy, L J; Siddiqi, T A; Khan, S 1991. C-jun and jun-B oncogene expression during placental development. American journal of obstetrics and gynecology, 165 6 Pt 1, 1853-6Dungy, L J; Siddiqi, T A; Khan, S 1991. Transforming growth factor-beta 1 expression during placental development. American journal of obstetrics and gynecology, 165 4 Pt 1, 853-7Raza, A; Bokhari, J; Yousuf, N; Mehdi, A; Mazewski, C; Khan, S; Baker, V; Lampkin, B 1991. Cell cycle kinetic studies in human cancers. Development of three DNA-specific labels in three decades. Archives of pathology & laboratory medicine, 115 9, 873-9Khan, S A; Moulton, B C 1990. Regulation of 3-hydroxyl-3-methylglutaryl-coenzyme A reductase activity in rat uterine tissues. Journal of steroid biochemistry, 35 6, 701-4Webb, D K; Moulton, B C; Khan, S A 1990. Estrogen induced expression of the C-jun proto-oncogene in the immature and mature rat uterus. Biochemical and biophysical research communications, 168 2, 721-6Dush, M K; Briggs, M R; Royce, M E; Schaff, D A; Khan, S A; Tischfield, J A; Stambrook, P J 1988. Identification of DNA sequences required for mouse APRT gene expression. Nucleic acids research, 16 17, 8509-24Jensen, Elwood V; Khan, Sohaib A . A two-site model for antiestrogen action. Mechanisms of ageing and development, 125 10-11, 679-82
Research Interests1) To understand the mechanism by which cells control the level of cholesterol in the body, we are studying the transcriptional regulation of the rat HMG-CoA reductase (HMGR) gene. HMGR is the rate limiting enzyme of cellular cholesterol synthesis. 2) Inthe second project, we are studying the role insulin plays in the regulation of glycogen phosphorylase gene. 3) In the other project underway, we are studying the role oncogenes play in cell differentiation.
Peer Reviewed Publications Kadel, Sapana; Ainsua-Enrich, Erola; Hatipoglu, Ibrahim; Turner, Sean; Singh, Simar; Khan, Sohaib; Kovats, Susan 2018. A Major Population of Functional KLRG1- ILC2s in Female Lungs Contributes to a Sex Bias in ILC2 Numbers. ImmunoHorizons, 2 2, 74-86Zhang, Jinsong; Gow, Chien-Hung; Khan, Sohaib; Liu, Ying; Yang, Chuanwei 2017. Transcriptional and Genomic Control of Stem Cells in Development and Cancer. Stem cells international, 2017 , 2513598Garrison, Jason B; Ge, Chunmin; Che, Lixiao; Pullum, Derek A; Peng, Guang; Khan, Sohaib; Ben-Jonathan, Nira; Wang, Jiang; Du, Chunying 2015. Knockdown of the Inhibitor of Apoptosis BRUCE Sensitizes Resistant Breast Cancer Cells to Chemotherapeutic Agents. Journal of cancer science & therapy, 7 4, 121-126Vallabhapurapu, Subrahmanya D; Noothi, Sunil K; Pullum, Derek A; Lawrie, Charles H; Pallapati, Rachel; Potluri, Veena; Kuntzen, Christian; Khan, Sohaib; Plas, David R; Orlowski, Robert Z; Chesi, Marta; Kuehl, W Michael; Bergsagel, P Leif; Karin, Michael; Vallabhapurapu, Sivakumar 2015. Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth. Nature communications, 6 , 8428Feng, Yuxin; Singleton, David; Guo, Chun; Gardner, Amanda; Pakala, Suresh; Kumar, Rakesh; Jensen, Elwood; Zhang, Jinsong; Khan, Sohaib 2013. DNA homologous recombination factor SFR1 physically and functionally interacts with estrogen receptor alpha. PloS one, 8 7, e68075Guo, Chun; Gow, Chien-Hung; Li, Yali; Gardner, Amanda; Khan, Sohaib; Zhang, Jinsong 2012. Regulated clearance of histone deacetylase 3 protects independent formation of nuclear receptor corepressor complexes. The Journal of biological chemistry, 287 15, 12111-20Marshall, Aaron M; McClaine, Rebecca J; Gurusamy, Devikala; Gray, Jerilyn K; Lewnard, Kara E; Khan, Sohaib A; Waltz, Susan E 2012. Estrogen receptor alpha deletion enhances the metastatic phenotype of Ron overexpressing mammary tumors in mice. Molecular cancer, 11 , 2Jiang, Pingping; Hu, Qiuping; Ito, Mitsuhiro; Meyer, Sara; Waltz, Susan; Khan, Sohaib; Roeder, Robert G; Zhang, Xiaoting 2010. Key roles for MED1 LxxLL motifs in pubertal mammary gland development and luminal-cell differentiation. Proceedings of the National Academy of Sciences of the United States of America, 107 15, 6765-70Khan, Sohaib; Lingrel, Jerry B 2010. Thematic minireview series on nuclear receptors in biology and diseases. The Journal of biological chemistry, 285 50, 38741-2Naciff, Jorge M; Khambatta, Zubin S; Reichling, Timothy D; Carr, Gregory J; Tiesman, Jay P; Singleton, David W; Khan, Sohaib A; Daston, George P 2010. The genomic response of Ishikawa cells to bisphenol A exposure is dose- and time-dependent. Toxicology, 270 2-3, 137-49Khan, Shah-Naz Hayat; Abruzzo, Todd A; Ringer, Andrew J 2009. Successful endovascular reconstruction of acutely ruptured pseudoaneurysm of the vertebral artery, complicated by isolated vertebrobasilar circulation and symptomatic vasospasm. Clinical neurology and neurosurgery, 111 10, 868-73Naciff, Jorge M; Khambatta, Zubin S; Thomason, Ryan G; Carr, Gregory J; Tiesman, Jay P; Singleton, David W; Khan, Sohaib A; Daston, George P 2009. The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicological sciences : an official journal of the Society of Toxicology, 107 1, 40-55Kojetin, Douglas J; Burris, Thomas P; Jensen, Elwood V; Khan, Sohaib A 2008. Implications of the binding of tamoxifen to the coactivator recognition site of the estrogen receptor. Endocrine-related cancer, 15 4, 851-70Tharakan, Robin; Lepont, Pierig; Singleton, David; Kumar, Rakesh; Khan, Sohaib 2008. Phosphorylation of estrogen receptor alpha, serine residue 305 enhances activity. Molecular and cellular endocrinology, 295 1-2, 70-8Yang, Jun; Singleton, David W; Shaughnessy, Elizabeth A; Khan, Sohaib A 2008. The F-domain of estrogen receptor-alpha inhibits ligand induced receptor dimerization. Molecular and cellular endocrinology, 295 1-2, 94-100Feng, Yuxin; Manka, David; Wagner, Kay-Uwe; Khan, Sohaib A 2007. Estrogen receptor-alpha expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice. Proceedings of the National Academy of Sciences of the United States of America, 104 37, 14718-23Ingraham, Susan E; Lynch, Roy A; Surti, Urvashi; Rutter, Joni L; Buckler, Alan J; Khan, Sohaib A; Menon, Anil G; Lepont, Pierig 2006. Identification and characterization of novel human transcripts embedded within HMGA2 in t(12;14)(q15;q24.1) uterine leiomyoma. Mutation research, 602 1-2, 43-53Singleton, David W; Feng, Yuxin; Yang, Jun; Puga, Alvaro; Lee, Adrian V; Khan, Sohaib A 2006. Gene expression profiling reveals novel regulation by bisphenol-A in estrogen receptor-alpha-positive human cells. Environmental research, 100 1, 86-92Singleton, David W; Feng, Yuxin; Chen, Yangde; Busch, Steve J; Lee, Adrian V; Puga, Alvaro; Khan, Sohaib A 2004. Bisphenol-A and estradiol exert novel gene regulation in human MCF-7 derived breast cancer cells. Molecular and cellular endocrinology, 221 1-2, 47-55Sheeler, Cameron Q; Singleton, David W; Khan, Sobhaib A 2003. Mutation of serines 104, 106, and 118 inhibits dimerization of the human estrogen receptor in yeast. Endocrine research, 29 2, 237-55Singleton, David W; Feng, Yuxin; Burd, Craig J; Khan, Sohaib A 2003. Nongenomic activity and subsequent c-fos induction by estrogen receptor ligands are not sufficient to promote deoxyribonucleic acid synthesis in human endometrial adenocarcinoma cells. Endocrinology, 144 1, 121-8Singleton, David W; Khan, Sohaib A 2003. Xenoestrogen exposure and mechanisms of endocrine disruption. Frontiers in bioscience : a journal and virtual library, 8 , s110-8Dudley, M W; Sheeler, C Q; Wang, H; Khan, S 2000. Activation of the human estrogen receptor by the antiestrogens ICI 182,780 and tamoxifen in yeast genetic systems: implications for their mechanism of action. Proceedings of the National Academy of Sciences of the United States of America, 97 7, 3696-701Nephew, K P; Choi, C M; Polek, T C; McBride, R; Bigsby, R M; Khan, S A; Husseinzadeh, N 2000. Expression of fos and jun proto-oncogenes in benign versus malignant human uterine tissue. Gynecologic oncology, 76 3, 388-96Puga, A; Barnes, S J; Chang, C; Zhu, H; Nephew, K P; Khan, S A; Shertzer, H G 2000. Activation of transcription factors activator protein-1 and nuclear factor-kappaB by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochemical pharmacology, 59 8, 997-1005Sheeler, C Q; Dudley, M W; Khan, S A 2000. Environmental estrogens induce transcriptionally active estrogen receptor dimers in yeast: activity potentiated by the coactivator RIP140. Environmental health perspectives, 108 2, 97-103Peters, G A; Khan, S A 1999. Estrogen receptor domains E and F: role in dimerization and interaction with coactivator RIP-140. Molecular endocrinology (Baltimore, Md.), 13 2, 286-96Wang, H; Zeng, X; Khan, S A 1999. Estrogen receptor variants ERdelta5 and ERdelta7 down-regulate wild-type estrogen receptor activity. Molecular and cellular endocrinology, 156 1-2, 159-68Allen, D L; Mitchner, N A; Uveges, T E; Nephew, K P; Khan, S; Ben-Jonathan, N 1997. Cell-specific induction of c-fos expression in the pituitary gland by estrogen. Endocrinology, 138 5, 2128-35Moulton, B C; Motz, J; Serdoncillo, C; Akcali, K C; Khan, S A 1997. Progesterone withdrawal and RU-486 treatment stimulate apoptosis in specific uterine decidual cells. Cell death and differentiation, 4 1, 76-81Akcali, K C; Khan, S A; Moulton, B C 1996. Effect of decidualization on the expression of bax and bcl-2 in the rat uterine endometrium. Endocrinology, 137 7, 3123-31Meng, J J; Khan, S; Ip, W 1996. Intermediate filament protein domain interactions as revealed by two-hybrid screens. The Journal of biological chemistry, 271 3, 1599-604Nephew, K P; Polek, T C; Khan, S A 1996. Tamoxifen-induced proto-oncogene expression persists in uterine endometrial epithelium. Endocrinology, 137 1, 219-24Nephew, K P; Peters, G A; Khan, S A 1995. Cellular localization of estradiol-induced c-fos messenger ribonucleic acid in the rat uterus: c-fos expression and uterine cell proliferation do not correlate strictly. Endocrinology, 136 7, 3007-15Wang, H; Peters, G A; Zeng, X; Tang, M; Ip, W; Khan, S A 1995. Yeast two-hybrid system demonstrates that estrogen receptor dimerization is ligand-dependent in vivo. The Journal of biological chemistry, 270 40, 23322-9Makarova, I; Carpenter, D; Khan, S; Ip, W 1994. A conserved region in the tail domain of vimentin is involved in its assembly into intermediate filaments. Cell motility and the cytoskeleton, 28 3, 265-77Meng, J J; Khan, S; Ip, W 1994. Charge interactions in the rod domain drive formation of tetramers during intermediate filament assembly. The Journal of biological chemistry, 269 28, 18679-85Nephew, K P; Tang, M; Khan, S A 1994. Estrogen differentially affects c-jun expression in uterine tissue compartments. Endocrinology, 134 4, 1827-34Cho, F S; Phillips, K S; Khan, S A; Weaver, T E 1993. Cloning of the rat cyclin-dependent kinase 4 cDNA: implication in proliferation-dependent expression in rat tissues. Biochemical and biophysical research communications, 191 3, 860-5Nephew, K P; Polek, T C; Akcali, K C; Khan, S A 1993. The antiestrogen tamoxifen induces c-fos and jun-B, but not c-jun or jun-D, protooncogenes in the rat uterus. Endocrinology, 133 1, 419-22Nephew, K P; Webb, D K; Akcali, K C; Moulton, B C; Khan, S A 1993. Hormonal regulation and expression of the jun-D protooncogene in specific cell types of the rat uterus. The Journal of steroid biochemistry and molecular biology, 46 3, 281-7Webb, D K; Moulton, B C; Khan, S A 1993. Estrogen induces expression of c-jun and jun-B protooncogenes in specific rat uterine cells. Endocrinology, 133 1, 20-8Moulton, B C; Khan, S A 1992. Progestin and estrogen control of cathepsin D expression and processing in rat uterine luminal epithelium and stroma-myometrium. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 201 1, 98-105Raza, A; Yousuf, N; Bokhari, S A; Mehdi, A; Masterson, M; Lampkin, B; Yanik, G; Mazewski, C; Khan, S; Preisler, H 1992. Contribution of in vivo proliferation/differentiation studies toward the development of a combined functional and morphologic system of classification of neoplastic diseases. Cancer, 69 6 Suppl, 1557-66Dungy, L J; Siddiqi, T A; Khan, S 1991. C-jun and jun-B oncogene expression during placental development. American journal of obstetrics and gynecology, 165 6 Pt 1, 1853-6Dungy, L J; Siddiqi, T A; Khan, S 1991. Transforming growth factor-beta 1 expression during placental development. American journal of obstetrics and gynecology, 165 4 Pt 1, 853-7Raza, A; Bokhari, J; Yousuf, N; Mehdi, A; Mazewski, C; Khan, S; Baker, V; Lampkin, B 1991. Cell cycle kinetic studies in human cancers. Development of three DNA-specific labels in three decades. Archives of pathology & laboratory medicine, 115 9, 873-9Khan, S A; Moulton, B C 1990. Regulation of 3-hydroxyl-3-methylglutaryl-coenzyme A reductase activity in rat uterine tissues. Journal of steroid biochemistry, 35 6, 701-4Webb, D K; Moulton, B C; Khan, S A 1990. Estrogen induced expression of the C-jun proto-oncogene in the immature and mature rat uterus. Biochemical and biophysical research communications, 168 2, 721-6Dush, M K; Briggs, M R; Royce, M E; Schaff, D A; Khan, S A; Tischfield, J A; Stambrook, P J 1988. Identification of DNA sequences required for mouse APRT gene expression. Nucleic acids research, 16 17, 8509-24Jensen, Elwood V; Khan, Sohaib A . A two-site model for antiestrogen action. Mechanisms of ageing and development, 125 10-11, 679-82
Kadel, Sapana; Ainsua-Enrich, Erola; Hatipoglu, Ibrahim; Turner, Sean; Singh, Simar; Khan, Sohaib; Kovats, Susan 2018. A Major Population of Functional KLRG1- ILC2s in Female Lungs Contributes to a Sex Bias in ILC2 Numbers. ImmunoHorizons, 2 2, 74-86Zhang, Jinsong; Gow, Chien-Hung; Khan, Sohaib; Liu, Ying; Yang, Chuanwei 2017. Transcriptional and Genomic Control of Stem Cells in Development and Cancer. Stem cells international, 2017 , 2513598Garrison, Jason B; Ge, Chunmin; Che, Lixiao; Pullum, Derek A; Peng, Guang; Khan, Sohaib; Ben-Jonathan, Nira; Wang, Jiang; Du, Chunying 2015. Knockdown of the Inhibitor of Apoptosis BRUCE Sensitizes Resistant Breast Cancer Cells to Chemotherapeutic Agents. Journal of cancer science & therapy, 7 4, 121-126Vallabhapurapu, Subrahmanya D; Noothi, Sunil K; Pullum, Derek A; Lawrie, Charles H; Pallapati, Rachel; Potluri, Veena; Kuntzen, Christian; Khan, Sohaib; Plas, David R; Orlowski, Robert Z; Chesi, Marta; Kuehl, W Michael; Bergsagel, P Leif; Karin, Michael; Vallabhapurapu, Sivakumar 2015. Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth. Nature communications, 6 , 8428Feng, Yuxin; Singleton, David; Guo, Chun; Gardner, Amanda; Pakala, Suresh; Kumar, Rakesh; Jensen, Elwood; Zhang, Jinsong; Khan, Sohaib 2013. DNA homologous recombination factor SFR1 physically and functionally interacts with estrogen receptor alpha. PloS one, 8 7, e68075Guo, Chun; Gow, Chien-Hung; Li, Yali; Gardner, Amanda; Khan, Sohaib; Zhang, Jinsong 2012. Regulated clearance of histone deacetylase 3 protects independent formation of nuclear receptor corepressor complexes. The Journal of biological chemistry, 287 15, 12111-20Marshall, Aaron M; McClaine, Rebecca J; Gurusamy, Devikala; Gray, Jerilyn K; Lewnard, Kara E; Khan, Sohaib A; Waltz, Susan E 2012. Estrogen receptor alpha deletion enhances the metastatic phenotype of Ron overexpressing mammary tumors in mice. Molecular cancer, 11 , 2Jiang, Pingping; Hu, Qiuping; Ito, Mitsuhiro; Meyer, Sara; Waltz, Susan; Khan, Sohaib; Roeder, Robert G; Zhang, Xiaoting 2010. Key roles for MED1 LxxLL motifs in pubertal mammary gland development and luminal-cell differentiation. Proceedings of the National Academy of Sciences of the United States of America, 107 15, 6765-70Khan, Sohaib; Lingrel, Jerry B 2010. Thematic minireview series on nuclear receptors in biology and diseases. The Journal of biological chemistry, 285 50, 38741-2Naciff, Jorge M; Khambatta, Zubin S; Reichling, Timothy D; Carr, Gregory J; Tiesman, Jay P; Singleton, David W; Khan, Sohaib A; Daston, George P 2010. The genomic response of Ishikawa cells to bisphenol A exposure is dose- and time-dependent. Toxicology, 270 2-3, 137-49Khan, Shah-Naz Hayat; Abruzzo, Todd A; Ringer, Andrew J 2009. Successful endovascular reconstruction of acutely ruptured pseudoaneurysm of the vertebral artery, complicated by isolated vertebrobasilar circulation and symptomatic vasospasm. Clinical neurology and neurosurgery, 111 10, 868-73Naciff, Jorge M; Khambatta, Zubin S; Thomason, Ryan G; Carr, Gregory J; Tiesman, Jay P; Singleton, David W; Khan, Sohaib A; Daston, George P 2009. The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicological sciences : an official journal of the Society of Toxicology, 107 1, 40-55Kojetin, Douglas J; Burris, Thomas P; Jensen, Elwood V; Khan, Sohaib A 2008. Implications of the binding of tamoxifen to the coactivator recognition site of the estrogen receptor. Endocrine-related cancer, 15 4, 851-70Tharakan, Robin; Lepont, Pierig; Singleton, David; Kumar, Rakesh; Khan, Sohaib 2008. Phosphorylation of estrogen receptor alpha, serine residue 305 enhances activity. Molecular and cellular endocrinology, 295 1-2, 70-8Yang, Jun; Singleton, David W; Shaughnessy, Elizabeth A; Khan, Sohaib A 2008. The F-domain of estrogen receptor-alpha inhibits ligand induced receptor dimerization. Molecular and cellular endocrinology, 295 1-2, 94-100Feng, Yuxin; Manka, David; Wagner, Kay-Uwe; Khan, Sohaib A 2007. Estrogen receptor-alpha expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice. Proceedings of the National Academy of Sciences of the United States of America, 104 37, 14718-23Ingraham, Susan E; Lynch, Roy A; Surti, Urvashi; Rutter, Joni L; Buckler, Alan J; Khan, Sohaib A; Menon, Anil G; Lepont, Pierig 2006. Identification and characterization of novel human transcripts embedded within HMGA2 in t(12;14)(q15;q24.1) uterine leiomyoma. Mutation research, 602 1-2, 43-53Singleton, David W; Feng, Yuxin; Yang, Jun; Puga, Alvaro; Lee, Adrian V; Khan, Sohaib A 2006. Gene expression profiling reveals novel regulation by bisphenol-A in estrogen receptor-alpha-positive human cells. Environmental research, 100 1, 86-92Singleton, David W; Feng, Yuxin; Chen, Yangde; Busch, Steve J; Lee, Adrian V; Puga, Alvaro; Khan, Sohaib A 2004. Bisphenol-A and estradiol exert novel gene regulation in human MCF-7 derived breast cancer cells. Molecular and cellular endocrinology, 221 1-2, 47-55Sheeler, Cameron Q; Singleton, David W; Khan, Sobhaib A 2003. Mutation of serines 104, 106, and 118 inhibits dimerization of the human estrogen receptor in yeast. Endocrine research, 29 2, 237-55Singleton, David W; Feng, Yuxin; Burd, Craig J; Khan, Sohaib A 2003. Nongenomic activity and subsequent c-fos induction by estrogen receptor ligands are not sufficient to promote deoxyribonucleic acid synthesis in human endometrial adenocarcinoma cells. Endocrinology, 144 1, 121-8Singleton, David W; Khan, Sohaib A 2003. Xenoestrogen exposure and mechanisms of endocrine disruption. Frontiers in bioscience : a journal and virtual library, 8 , s110-8Dudley, M W; Sheeler, C Q; Wang, H; Khan, S 2000. Activation of the human estrogen receptor by the antiestrogens ICI 182,780 and tamoxifen in yeast genetic systems: implications for their mechanism of action. Proceedings of the National Academy of Sciences of the United States of America, 97 7, 3696-701Nephew, K P; Choi, C M; Polek, T C; McBride, R; Bigsby, R M; Khan, S A; Husseinzadeh, N 2000. Expression of fos and jun proto-oncogenes in benign versus malignant human uterine tissue. Gynecologic oncology, 76 3, 388-96Puga, A; Barnes, S J; Chang, C; Zhu, H; Nephew, K P; Khan, S A; Shertzer, H G 2000. Activation of transcription factors activator protein-1 and nuclear factor-kappaB by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochemical pharmacology, 59 8, 997-1005Sheeler, C Q; Dudley, M W; Khan, S A 2000. Environmental estrogens induce transcriptionally active estrogen receptor dimers in yeast: activity potentiated by the coactivator RIP140. Environmental health perspectives, 108 2, 97-103Peters, G A; Khan, S A 1999. Estrogen receptor domains E and F: role in dimerization and interaction with coactivator RIP-140. Molecular endocrinology (Baltimore, Md.), 13 2, 286-96Wang, H; Zeng, X; Khan, S A 1999. Estrogen receptor variants ERdelta5 and ERdelta7 down-regulate wild-type estrogen receptor activity. Molecular and cellular endocrinology, 156 1-2, 159-68Allen, D L; Mitchner, N A; Uveges, T E; Nephew, K P; Khan, S; Ben-Jonathan, N 1997. Cell-specific induction of c-fos expression in the pituitary gland by estrogen. Endocrinology, 138 5, 2128-35Moulton, B C; Motz, J; Serdoncillo, C; Akcali, K C; Khan, S A 1997. Progesterone withdrawal and RU-486 treatment stimulate apoptosis in specific uterine decidual cells. Cell death and differentiation, 4 1, 76-81Akcali, K C; Khan, S A; Moulton, B C 1996. Effect of decidualization on the expression of bax and bcl-2 in the rat uterine endometrium. Endocrinology, 137 7, 3123-31Meng, J J; Khan, S; Ip, W 1996. Intermediate filament protein domain interactions as revealed by two-hybrid screens. The Journal of biological chemistry, 271 3, 1599-604Nephew, K P; Polek, T C; Khan, S A 1996. Tamoxifen-induced proto-oncogene expression persists in uterine endometrial epithelium. Endocrinology, 137 1, 219-24Nephew, K P; Peters, G A; Khan, S A 1995. Cellular localization of estradiol-induced c-fos messenger ribonucleic acid in the rat uterus: c-fos expression and uterine cell proliferation do not correlate strictly. Endocrinology, 136 7, 3007-15Wang, H; Peters, G A; Zeng, X; Tang, M; Ip, W; Khan, S A 1995. Yeast two-hybrid system demonstrates that estrogen receptor dimerization is ligand-dependent in vivo. The Journal of biological chemistry, 270 40, 23322-9Makarova, I; Carpenter, D; Khan, S; Ip, W 1994. A conserved region in the tail domain of vimentin is involved in its assembly into intermediate filaments. Cell motility and the cytoskeleton, 28 3, 265-77Meng, J J; Khan, S; Ip, W 1994. Charge interactions in the rod domain drive formation of tetramers during intermediate filament assembly. The Journal of biological chemistry, 269 28, 18679-85Nephew, K P; Tang, M; Khan, S A 1994. Estrogen differentially affects c-jun expression in uterine tissue compartments. Endocrinology, 134 4, 1827-34Cho, F S; Phillips, K S; Khan, S A; Weaver, T E 1993. Cloning of the rat cyclin-dependent kinase 4 cDNA: implication in proliferation-dependent expression in rat tissues. Biochemical and biophysical research communications, 191 3, 860-5Nephew, K P; Polek, T C; Akcali, K C; Khan, S A 1993. The antiestrogen tamoxifen induces c-fos and jun-B, but not c-jun or jun-D, protooncogenes in the rat uterus. Endocrinology, 133 1, 419-22Nephew, K P; Webb, D K; Akcali, K C; Moulton, B C; Khan, S A 1993. Hormonal regulation and expression of the jun-D protooncogene in specific cell types of the rat uterus. The Journal of steroid biochemistry and molecular biology, 46 3, 281-7Webb, D K; Moulton, B C; Khan, S A 1993. Estrogen induces expression of c-jun and jun-B protooncogenes in specific rat uterine cells. Endocrinology, 133 1, 20-8Moulton, B C; Khan, S A 1992. Progestin and estrogen control of cathepsin D expression and processing in rat uterine luminal epithelium and stroma-myometrium. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 201 1, 98-105Raza, A; Yousuf, N; Bokhari, S A; Mehdi, A; Masterson, M; Lampkin, B; Yanik, G; Mazewski, C; Khan, S; Preisler, H 1992. Contribution of in vivo proliferation/differentiation studies toward the development of a combined functional and morphologic system of classification of neoplastic diseases. Cancer, 69 6 Suppl, 1557-66Dungy, L J; Siddiqi, T A; Khan, S 1991. C-jun and jun-B oncogene expression during placental development. American journal of obstetrics and gynecology, 165 6 Pt 1, 1853-6Dungy, L J; Siddiqi, T A; Khan, S 1991. Transforming growth factor-beta 1 expression during placental development. American journal of obstetrics and gynecology, 165 4 Pt 1, 853-7Raza, A; Bokhari, J; Yousuf, N; Mehdi, A; Mazewski, C; Khan, S; Baker, V; Lampkin, B 1991. Cell cycle kinetic studies in human cancers. Development of three DNA-specific labels in three decades. Archives of pathology & laboratory medicine, 115 9, 873-9Khan, S A; Moulton, B C 1990. Regulation of 3-hydroxyl-3-methylglutaryl-coenzyme A reductase activity in rat uterine tissues. Journal of steroid biochemistry, 35 6, 701-4Webb, D K; Moulton, B C; Khan, S A 1990. Estrogen induced expression of the C-jun proto-oncogene in the immature and mature rat uterus. Biochemical and biophysical research communications, 168 2, 721-6Dush, M K; Briggs, M R; Royce, M E; Schaff, D A; Khan, S A; Tischfield, J A; Stambrook, P J 1988. Identification of DNA sequences required for mouse APRT gene expression. Nucleic acids research, 16 17, 8509-24Jensen, Elwood V; Khan, Sohaib A . A two-site model for antiestrogen action. Mechanisms of ageing and development, 125 10-11, 679-82