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Cancer Institute

Xiaoting Zhang, PhD

Associate Professor

Education/Credentials
  • Bachelor's Degree: Zhejiang University
  • Master's Degree: Fudan University
  • Doctoral Degree: The University of Iowa
  • Fellowship: Rockefeller University

Research/Clinical Interests

Mechanisms of transcriptional and epigenetic regulation of gene expression in breast cancer and development of RNA-based nanotherapuetics.

Contact Information
  • Vontz Center for Molecular Studies
  • 3125 Eden Avenue
  • ML 0521
  • Cincinnati, Ohio 45267
  • Office 513-558-3017
  • Email xiaoting.zhang@uc.edu

Peer Reviewed Publications

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Yang, Yongguang; Leonard, Marissa; Zhang, Yijuan; Zhao, Dan; Mahmoud, Charif; Khan, Shugufta; Wang, Jiang; Lower, Elyse E; Zhang, Xiaoting 2018. HER2-Driven Breast Tumorigenesis Relies upon Interactions of the Estrogen Receptor with Coactivator MED1. Cancer research, 78 2, 422-435

Leonard M and Zhang X 2016. First Therapeutic Aptamer: VEGF-Targeting Macugen Aptamers: Tools for Targeted Nanotherapy and Molecular Imaging, Pan Stanford Publishing , Page 319-335.

Zhang Y, Leonard M, Shu Y, Yang Y, Shu D, Guo P, and Zhang X. 2016. Overcoming Tamoxifen Resistance of Human Breast Cancer by Targeted Gene Silencing Using Multifunctional pRNA Nanoparticles ACS Nano , 11 1, 335-346

Leonard M, Zhang Y and Zhang X. 2015. Small non-coding RNAs and aptamers in diagnostics and therapeutics Methods in Molecular Biology, 1296 , 225-33

Leonard, Marissa; Zhang, Yijuan; Zhang, Xiaoting 2015. Small non-coding RNAs and aptamers in diagnostics and therapeutics. Methods in molecular biology (Clifton, N.J.), 1296 , 225-33

Czyzyk-Krzeska, M F; Zhang, X 2014. MiR-155 at the heart of oncogenic pathways Oncogene, 33 6, 677-8

Germer, Katherine; Leonard, Marissa; Zhang, Xiaoting 2013. RNA aptamers and their therapeutic and diagnostic applications. International Journal of Biochemistry and Molecular Biology, 4 1, 27-40

Zhang L; Cui J; Leonard M; Nephew K; Li Y and Zhang X 2013. Silencing MED1 Sensitizes Breast Cancer Cells to pure Anti-estrogen Fulvestrant Therapy in vitro and in vivo PLoS ONE , 8(7): e70641 ,

Zhang, Lijiang; Cui, Jiajun; Leonard, Marissa; Nephew, Kenneth; Li, Yongquan; Zhang, Xiaoting 2013. Silencing MED1 sensitizes breast cancer cells to pure anti-estrogen fulvestrant in vitro and in vivo. PloS one, 8 7, e70641

Cui J, Germer K, Wu T, Wang J, Luo J, Wang SC, Wang Q, and Zhang X 2012. Cross-talk Between HER2 and MED1 Regulates Tamoxifen Resistance of Human Breast Cancer Cells Cancer Research, 72 21, 5625-34

Cui, Jiajun; Germer, Katherine; Wu, Tianying; Wang, Jiang; Luo, Jia; Wang, Shao-chun; Wang, Qianben; Zhang, Xiaoting 2012. Cross-talk between HER2 and MED1 regulates tamoxifen resistance of human breast cancer cells. Cancer research, 72 21, 5625-34

Chen Z, Zhang C, Wu D, Rorick A, Zhang X, and Wang Q 2011. Specific phosphorylation of coactivator Mediator 1coding for UBE2C locus looping leads to androgen receptor negative prostate cancer growth EMBO J., 30(12):2405-19 ,

Pfaff D, Waters J, Kahn I, Zhang X and Numan M. 2011. Estrogen receptor-initiated mechanisms causal to mammalian reproductive behaviors. Endocrinology, 152 4, 1209-17

Zhang D, Jiang P, Xu Q, and Zhang X 2011. ARGLU1 interacts with MED1 and is required for estrogen receptor-mediated transcription and breast cancer cell growth. Journal of Biological Chemistry, 286(20):17746-54 ,

Zhang, Dingxiao; Jiang, Pingping; Xu, Qinqin; Zhang, Xiaoting 2011. Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator subunit 1 (MED1) and is required for estrogen receptor-mediated gene transcription and breast cancer cell growth. The Journal of biological chemistry, 286 20, 17746-54

Chen, W.; Zhang, X.; Birsoy, K.; Roeder, R. G. 2010. A muscle-specific knockout implicates nuclear receptor coactivator MED1 in the regulation of glucose and energy metabolism Proc Natl Acad Sci U S A, 107 22 , 10196-201

Jiang, P.; Hu, Q.; Ito, M.; Meyer, S.; Waltz, S.; Khan, S.; Roeder, R. G.; Zhang, X. 2010. Key roles for MED1 LxxLL motifs in pubertal mammary gland development and luminal-cell differentiation Proc Natl Acad Sci U S A, 107 15 , 6765-70

Jiang, Pingping; Hu, Qiuping; Ito, Mitsuhiro; Meyer, Sara; Waltz, Susan; Khan, Sohaib; Roeder, Robert G; Zhang, Xiaoting 2010. Key roles for MED1 LxxLL motifs in pubertal mammary gland development and luminal-cell differentiation. Proceedings of the National Academy of Sciences of the United States of America, 107 15, 6765-70

Zhang, X; Leung, Y-K; Ho, S-M 2007. AP-2 regulates the transcription of estrogen receptor (ER)-beta by acting through a methylation hotspot of the 0N promoter in prostate cancer cells. Oncogene, 26 52, 7346-54

Stumpf M, Waskow C, Krötschel M, Essen D, Rodriguez P, Zhang X, Guyot B, Roeder RG and Borggrefe T. 2006. The Mediator Complex Functions as a Coactivator for GATA1 in Erythropoiesis via Subunit Med1/TRAP220 Proc. Natl. Acad. Sci., 103:18504-9 ,

Zhang, X.; Kolaczkowska, A.; Devaux, F.; Panwar, S. L.; Hallstrom, T. C.; Jacq, C.; Moye-Rowley, W. S. 2005. Transcriptional regulation by Lge1p requires a function independent of its role in histone H2B ubiquitination J Biol Chem, 280 4 , 2759-70

Zhang, X.; Krutchinsky, A.; Fukuda, A.; Chen, W.; Yamamura, S.; Chait, B. T.; Roeder, R. G. 2005. MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription Mol Cell, 19 1 , 89-100

Le Crom, S.; Devaux, F.; Marc, P.; Zhang, X.; Moye-Rowley, W. S.; Jacq, C. 2002. New insights into the pleiotropic drug resistance network from genome-wide characterization of the YRR1 transcription factor regulation system Mol Cell Biol, 22 8 , 2642-9

Zhang, X.; Cui, Z.; Miyakawa, T.; Moye-Rowley, W. S. 2001. Cross-talk between transcriptional regulators of multidrug resistance in Saccharomyces cerevisiae J Biol Chem, 276 12 , 8812-9

Zhang, X.; Moye-Rowley, W. S. 2001. Saccharomyces cerevisiae multidrug resistance gene expression inversely correlates with the status of the F(0) component of the mitochondrial ATPase J Biol Chem, 276 51 , 47844-52

Zhang, X.; De Micheli, M.; Coleman, S. T.; Sanglard, D.; Moye-Rowley, W. S. 2000. Analysis of the oxidative stress regulation of the Candida albicans transcription factor, Cap1p Mol Microbiol, 36 3 , 618-29

Zhang, X., Ma, B., Shu, N., Chen, SZ, and Zhao, SY. 1997. Cloning the Gene Coding for Human Glial Cell Line-derived Neurotrophic Factor and its Expression in Escherichia Coli Chinese Journal of Biotechnology, 13(4): 426-9 ,

Zhang, X., Chen, SZ, and Zhao, SY. 1996. The Gene Structure of Ciliary Neurotrophic Factor and its Receptor Foreign Med. Sci. (Molecular Biology), 18(5):225-9 ,