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Department of

Orthopaedic Surgery

Photo of  Chia-Ying Lin, PhD

Chia-Ying Lin, PhD

Mary S. and Joseph S. Stern Jr. Professor in Musculoskeletal Research

Education/Credentials
  • B.S.: National Taiwan University
  • M.S.: University of Michigan
  • Ph.D.: University of Michigan

Contact Information
  • 5452 Medical Sciences Building
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267-0212
  • Office (513)558-8412
  • Fax (513)558-2220
  • Email chia-ying.lin@uc.edu

Peer Reviewed Publications

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Gruber, Stacey M S; Ghosh, Paulomi; Mueller, Karl Wilhelm; Whitlock, Patrick W; Lin, Chia-Ying 2019. Novel Process for 3D Printing Decellularized Matrices. Journal of visualized experiments : JoVE, 143,

Nguyen, Khoi; Pan, Hsuan-Yeh; Haworth, Kevin; Mahoney, Eric; Mercado-Shekhar, Karla P; Lin, Chia-Ying; Zhang, Zhe; C Park, Yoonjee 2019. Multiple-Exposure Drug Release from Stable Nanodroplets by High-Intensity Focused Ultrasound for a Potential Degenerative Disc Disease Treatment. Ultrasound in medicine & biology, 45 1, 160-169

Oria, Marc; Tatu, Rigwed R; Lin, Chia-Ying; Peiro, Jose L 2019. In Vivo Evaluation of Novel PLA/PCL Polymeric Patch in Rats for Potential Spina Bifida Coverage. The Journal of surgical research, 242 , 62-69

Tatu, Rigwed; Oria, Marc; Pulliam, Sarah; Signey, Lorenzo; Rao, Marepalli B; Peiro, Jose L; Lin, Chia-Ying 2019. Using poly(l-lactic acid) and poly(?-caprolactone) blends to fabricate self-expanding, watertight and biodegradable surgical patches for potential fetoscopic myelomeningocele repair. Journal of biomedical materials research. Part B, Applied biomaterials, 107 2, 295-305

Ghosh, Paulomi; Gruber, Stacey M S; Lin, Chia-Ying; Whitlock, Patrick 2018. Microspheres containing decellularized cartilage induce chondrogenesis in vitro and remain functional after incorporation within a poly(caprolactone) filament useful for fabricating a 3D scaffold. Biofabrication, ,

Ghosh, Paulomi; Gruber, Stacey M S; Lin, Chia-Ying; Whitlock, Patrick W 2018. Microspheres containing decellularized cartilage induce chondrogenesis in vitro and remain functional after incorporation within a poly(caprolactone) filament useful for fabricating a 3D scaffold. Biofabrication, 10 2, 025007

Ma, Jun; He, Yunfei; Liu, Xilin; Chen, Weiming; Wang, An; Lin, Chia-Ying; Mo, Xiumei; Ye, Xiaojian 2018. A novel electrospun-aligned nanoyarn/three-dimensional porous nanofibrous hybrid scaffold for annulus fibrosus tissue engineering. International journal of nanomedicine, 13 , 1553-1567

Wang, Lizhen; Lin, Chia-Ying; Yao, Wei; Wong, Duo Wai-Chi; Zhu, Rui 2018. Biomechanics and Bioengineering of Orthopedic and Cardiovascular Rehabilitation. Journal of healthcare engineering, 2018 , 1716809

Xiong, Qisheng; Wang, Xuesong; Wang, Lizhen; Huang, Yan; Tian, Xiaodong; Fan, Yubo; Lin, Chia-Ying 2018. BMP-2 inhibits lung metastasis of osteosarcoma: an early investigation using an orthotopic model. OncoTargets and therapy, 11 , 7543-7553

Ni, Yikun; Wang, Lizhen; Liu, Xiaoyu; Zhang, Hongquan; Lin, Chia-Ying; Fan, Yubo 2017. Micro-mechanical properties of different sites on woodpecker's skull. Computer methods in biomechanics and biomedical engineering, 20 14, 1483-1493

Wang, Lin; Park, Paul; La Marca, Frank; Than, Khoi D; Lin, Chia-Ying 2015. BMP-2 inhibits tumor-initiating ability in human renal cancer stem cells and induces bone formation. Journal of cancer research and clinical oncology, 141 6, 1013-24

Than, Khoi D; Rahman, Shayan U; Wang, Lin; Khan, Adam; Kyere, Kwaku A; Than, Tracey T; Miyata, Yoshinari; Park, Yoon-Shin; La Marca, Frank; Kim, Hyungjin M; Zhang, Huina; Park, Paul; Lin, Chia-Ying 2014. Intradiscal injection of simvastatin results in radiologic, histologic, and genetic evidence of disc regeneration in a rat model of degenerative disc disease. The spine journal : official journal of the North American Spine Society, 14 6, 1017-28

Kang, Heesuk; Hollister, Scott J; La Marca, Frank; Park, Paul; Lin, Chia-Ying 2013. Porous biodegradable lumbar interbody fusion cage design and fabrication using integrated global-local topology optimization with laser sintering. Journal of biomechanical engineering, 135 10, 101013-8

Park, Yoon Shin; David, Allan E; Park, Kyung Min; Lin, Chia-Ying; Than, Khoi D; Lee, Kyuri; Park, Jun Beom; Jo, Inho; Park, Ki Dong; Yang, Victor C 2013. Controlled release of simvastatin from in situ forming hydrogel triggers bone formation in MC3T3-E1 cells. The AAPS journal, 15 2, 367-76

Wang, Lin; Park, Paul; La Marca, Frank; Than, Khoi; Rahman, Shayan; Lin, Chia-Ying 2013. Bone formation induced by BMP-2 in human osteosarcoma cells. International journal of oncology, 43 4, 1095-102

Lin, Chia-Ying 2012. Comment. Neurosurgery, 71 1, 125

Park, Jun-Beom; Zhang, Huina; Lin, Chia-Ying; Chung, Chong Pyoung; Byun, Youngro; Park, Yoon Shin; Yang, Victor C 2012. Simvastatin maintains osteoblastic viability while promoting differentiation by partially regulating the expressions of estrogen receptors ?. The Journal of surgical research, 174 2, 278-83

Than, Khoi D; Rahman, Shayan U; Vanaman, Monique J; Wang, Anthony C; Lin, Chia-Ying; Zhang, Huina; La Marca, Frank; Park, Paul 2012. Bone morphogenetic proteins and degenerative disk disease. Neurosurgery, 70 4, 996-1002; discussion

Wang, Lin; Park, Paul; Zhang, Huina; La Marca, Frank; Claeson, Amy; Than, Khoi; Rahman, Shayan; Lin, Chia-Ying 2012. BMP-2 inhibits tumor growth of human renal cell carcinoma and induces bone formation. International journal of cancer, 131 8, 1941-50

Wang, Lin; Rahman, Shayan; Lin, Chia-Ying; Valdivia, Juan; Than, Khoi; La Marca, Frank; Park, Paul 2012. A novel murine model of human renal cell carcinoma spinal metastasis. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 19 6, 881-3

Wang, Lin; Park, Paul; Zhang, Huina; La Marca, Frank; Claeson, Amy; Valdivia, Juan; Lin, Chia-Ying 2011. BMP-2 inhibits the tumorigenicity of cancer stem cells in human osteosarcoma OS99-1 cell line. Cancer biology & therapy, 11 5, 457-63

Wang, Lin; Park, Paul; Zhang, Huina; La Marca, Frank; Lin, Chia-Ying 2011. Prospective identification of tumorigenic osteosarcoma cancer stem cells in OS99-1 cells based on high aldehyde dehydrogenase activity. International journal of cancer, 128 2, 294-303

Zhang, Huina; Yang, Sushan; Wang, Lin; Park, Paul; La Marca, Frank; Hollister, Scott J; Lin, Chia-Ying 2011. Time course investigation of intervertebral disc degeneration produced by needle-stab injury of the rat caudal spine: laboratory investigation. Journal of neurosurgery. Spine, 15 4, 404-13

Kang, Heesuk; Park, Paul; La Marca, Frank; Hollister, Scott J; Lin, Chia-Ying 2010. Analysis of load sharing on uncovertebral and facet joints at the C5-6 level with implantation of the Bryan, Prestige LP, or ProDisc-C cervical disc prosthesis: an in vivo image-based finite element study. Neurosurgical focus, 28 6, E9

Lin, Chia-Ying; Wang, Lin; Than, Khoi; Marca, Frank La; Park, Paul 2010. Cancer stem cell markers: what is their diagnostic value? Expert opinion on medical diagnostics, 4 6, 473-81

Thawani, Jayesh P; Wang, Anthony C; Than, Khoi D; Lin, Chia-Ying; La Marca, Frank; Park, Paul 2010. Bone morphogenetic proteins and cancer: review of the literature. Neurosurgery, 66 2, 233-46; discussion 2

Zhang, Huina; Migneco, Francesco; Lin, Chia-Ying; Hollister, Scott J 2010. Chemically-conjugated bone morphogenetic protein-2 on three-dimensional polycaprolactone scaffolds stimulates osteogenic activity in bone marrow stromal cells. Tissue engineering. Part A, 16 11, 3441-8

Lin, Chia-Ying; Kang, Heesuk; Rouleau, Jeffrey P; Hollister, Scott J; Marca, Frank La 2009. Stress analysis of the interface between cervical vertebrae end plates and the Bryan, Prestige LP, and ProDisc-C cervical disc prostheses: an in vivo image-based finite element study. Spine, 34 15, 1554-60

Wang, Lin; Park, Paul; Lin, Chia-Ying 2009. Characterization of stem cell attributes in human osteosarcoma cell lines. Cancer biology & therapy, 8 6, 543-52

Zhang, Huina; La Marca, Frank; Hollister, Scott J; Goldstein, Steven A; Lin, Chia-Ying 2009. Developing consistently reproducible intervertebral disc degeneration at rat caudal spine by using needle puncture. Journal of neurosurgery. Spine, 10 6, 522-30

Zhang, Huina; Lin, Chia-Ying; Hollister, Scott J 2009. The interaction between bone marrow stromal cells and RGD-modified three-dimensional porous polycaprolactone scaffolds. Biomaterials, 30 25, 4063-9

Zhang, Huina; Wang, Lin; Park, Jun Beom; Park, Paul; Yang, Victor C; Hollister, Scott J; La Marca, Frank; Lin, Chia-Ying 2009. Intradiscal injection of simvastatin retards progression of intervertebral disc degeneration induced by stab injury. Arthritis research & therapy, 11 6, R172

Zhang, Huina; Lin, Chia-Ying 2008. Simvastatin stimulates chondrogenic phenotype of intervertebral disc cells partially through BMP-2 pathway. Spine, 33 16, E525-31

Lin, Chia-Ying; Wirtz, Tobias; LaMarca, Frank; Hollister, Scott J 2007. Structural and mechanical evaluations of a topology optimized titanium interbody fusion cage fabricated by selective laser melting process. Journal of biomedical materials research. Part A, 83 2, 272-9

Hollister, S J; Lin, C Y; Saito, E; Lin, C Y; Schek, R D; Taboas, J M; Williams, J M; Partee, B; Flanagan, C L; Diggs, A; Wilke, E N; Van Lenthe, G H; Müller, R; Wirtz, T; Das, S; Feinberg, S E; Krebsbach, P H 2005. Engineering craniofacial scaffolds. Orthodontics & craniofacial research, 8 3, 162-73

Huang, Chun-Hsiung; Liau, Jiann-Jong; Ho, Fang-Yuan; Lin, Chia-Yin; Young, Tai-Horng; Cheng, Cheng-Kung 2005. Polyethylene failure of the patellar component in New Jersey low-contact stress total knee arthroplasties. The Journal of arthroplasty, 20 2, 202-8

Hollister, Scott J; Lin, Chia-Ying; Lin, Cheng-Yu; Schek, Rachel D; Taboas, Juan M; Flanagan, Colleen L; Saito, Eiji; Williams, Jessica M; Das, Suman; Wirtz, Tobias; Krebsbach, Paul H 2004. Design and fabrication of scaffolds for anatomic bone reconstruction. The Medical journal of Malaysia, 59 Suppl B , 131-2

Lin, Chia-Ying; Hsiao, Chun-Ching; Chen, Po-Quan; Hollister, Scott J 2004. Interbody fusion cage design using integrated global layout and local microstructure topology optimization. Spine, 29 16, 1747-54

Adachi T.; Hollister S.; Kang H.; Lin C. 12-01-2008. Computational design and simulation of tissue engineering scaffolds Virtual Prototyping and Bio Manufacturing in Medical Applications, , 113-127

Brumblay H.; Hollister S.; Krebsbach P.; Lamarca F.; Leveque J.; Liao E.; Lin C.; Wong D. 12-01-2008. Engineered scaffold architecture influences soft tissue regeneration Bio-Materials and Prototyping Applications in Medicine, , 67-78

Hollister S.; Lin C. 12-01-2006. Image-based hierarchical analysis and design of tissue engineering scaffolds Mechanics of Biological Tissue, , 503-515

Das S.; Diggs A.; Feinberg S.; Flanagan C.; Hollister S.; Krebsbach P.; Lin C.; Müller R.; Partee B.; Saito E.; Schek R.; Taboas J.; Van Lenthe G.; Wilke E.; Williams J.; Wirtz T. 12-01-2005. Engineering craniofacial scaffolds Orthodontics and Craniofacial Research, 8 3, 162-173

Lin C.; Marca F.; Park P.; Than K.; Wang L. 11-01-2010. Cancer stem cell markers: What is their diagnostic value? Expert Opinion on Medical Diagnostics, 4 6, 473-481

Hollister S.; Kang H.; Lin C. 10-01-2010. Topology optimization of three dimensional tissue engineering scaffold architectures for prescribed Structural and Multidisciplinary Optimization, 42 4, 633-644

Lin C. 07-01-2012. Role of cancer stem cells in spine tumors: Review of current literature: Commentary Neurosurgery, 71 1, 125

Halloran J.; Hollister S.; Jongpaiboonkit L.; Krebsbach P.; Lin C. 04-04-2006. Mechanical behavior of complex 3D calcium phosphate cement scaffolds fabricated by indirect solid fr Key Engineering Materials, 309-311 II , 957-960

Fan Y.; Huang Y.; Lin C.; Tian X.; Wang L.; Wang X.; Xiong Q. 01-01-2018. BMP-2 inhibits lung metastasis of osteosarcoma: An early investigation using an orthotopic model OncoTargets and Therapy, 11 , 7543-7553

Lin C.; Tatu R. 01-01-2018. Chapter 2: Characterization of biomaterial patches as fetal surgery implants Frontiers in Nanobiomedical Research, 10 , 29-47

Lin C.; Wang L.; Wong D.; Yao W.; Zhu R. 01-01-2018. Biomechanics and Bioengineering of Orthopedic and Cardiovascular Rehabilitation Journal of Healthcare Engineering, 2018 ,

Lin C.; Tatu R. 01-01-2017. Characterization of biomaterial patches as fetal surgery implants Tissue Engineering and Nanotheranostics, , 29-48

Lin, Chia-Ying; Schek, Rachel M; Mistry, Amit S; Shi, Xinfeng; Mikos, Antonios G; Krebsbach, Paul H; Hollister, Scott J . Functional bone engineering using ex vivo gene therapy and topology-optimized, biodegradable polymer composite scaffolds. Tissue engineering, 11 9-10, 1589-98